A 56-year-old man presented to the emergency room with a sudden onset of drowsiness that began 2 hours before his arrival. Brain computed tomography revealed massive pneumocephalus. The patient was diagnosed cerebrospinal fluid leakage accompanied by septal perforation. planned skull base repair performed using multilayer reconstruction via trans-septal approach. Following surgery, patient’s mental state recovered, and defect successfully reconstructed. disclosed he had undergone faith...

Pregabalin is used to treat neuropathic pain and has shown analgesic properties in postoperative pain. The aim of this study was investigate the effectiveness safety pregabalin reducing patients after septoplasty.Forty-seven scheduled for elective septoplasty were randomly assigned groups that received either (150 mg) or placebo, both one hour before surgery 12 hours initial dose. Pain (verbal numerical rating scale, VNRS) side effect assessments performed at 6, 12, 24, 24 48...

The potential physiologic roles of Klotho in acute kidney injury (AKI) have recently been demonstrated animal models. However, to date, there no human studies investigating the expression renal AKI.We retrospectively collected biopsy specimens and clinical data AKI patients between January 2001 December 2012. was determined by immunohistochemical staining, clinical-pathological correlation examined.Among 34 diagnosed with tubular necrosis or tubulointerstitial nephritis, 21 without chronic...

It has been suggested that chronic kidney disease (CKD) is a risk factor for Clostridium difficile infection (CDI) and associated with increased mortality among patients infected C. difficile. However, recent studies of the clinical impact CKD on CDI in Asians are still insufficient. We sought to determine relationship between Korean population.This was single-center, retrospective case-control study. In total, 171 were included as cases 342 age- gender-matched without used controls....

This study examined the gene copy number change events at chromosome 20 in gastric cancer, and their possible relationship with recurrence using cDNA microarray-based comparative genomic hybridization.Thirty pairs of tumor normal tissues were used hybridization. The microarrays containing 17,000 sequence-verified human probes a direct comparison design, where DNAs from labeled fluorescent dyes Cy3 Cy5, respectively, cohybridized. Genes log(2) (Cy5/Cy3) > or = 0.58 least one case selected as...

Abstract Background Thymoma is a heterogeneous group of tumors in biology and clinical behavior. Even though thymoma divided into five subgroups following the World Health Organization classification, nature disease mixed within subgroups. Results We investigated molecular characteristics genetic changes variation using cDNA microarray based-comparative genomic hybridization (CGH) with 17 K an indirect, sex-matched design. Genomic DNA from paraffin embedded 39 tissues (A 6, AB 11, B1 7, B2...

While Trichomonas vaginalis, a cause of sexually transmitted infection, is known as surface-dwelling protozoa, trichomonads have been detected in prostatic tissue from benign hyperplasia and prostatitis by immunoperoxidase assay or PCR. However, the immune response prostate stromal cells infected with T. vaginalis has not investigated. Our objective was to investigate whether could induce an inflammatory cells. Incubation human myofibroblast (WPMY-1) live T016 increased expression chemokines...

Objectives/Hypothesis The aim of this study was to compare sinonasal‐related quality life (QOL) in patients treated by extended or transsellar endoscopic skull base surgery. Study Design Prospective data analysis. Methods Prospectively collected from who underwent surgery between 2012 and 2017 were analyzed. Primary outcomes preoperative Sino‐Nasal Outcome Test‐20 (SNOT‐20) scores then 1‐month, 3‐month, 6‐month follow‐up. Comparative analysis performed the approach (ETA) group (n = 647) an...

Abstract The aim of this study was to evaluate the effect topical administration onion ( Allium cepa) extract on nasal cavity for treatment allergic rhinitis (AR). BALB/c mice were sensitized by intraperitoneal injection ovalbumin (OVA) and challenged with intranasal instillation OVA or without extracts five times a week 3 consecutive weeks. Allergic symptom score according frequencies sneezing, serum total specific immunoglobulin E (IgE) level, cytokine levels mucosa eosinophilic...

Background Olfactory and gustatory dysfunction has been reported as characteristic symptoms of coronavirus disease 2019 (COVID-19). This study evaluated olfactory in mild COVID-19 patients using validated assessment methods. Methods A prospective surveillance was conducted for who were isolated at the Gyeonggi International Living Treatment Support Center (LTSC), Korea. function assessed Korean version Questionnaire Disorders (QOD) Cross-Cultural Smell Identification Test (CC-SIT). Gustatory...

Abstract Purpose: We evaluated the genome-wide gene expression profiles of various cancer cell lines to identify gastrointestinal tract cell–related genes. Experimental Design: Gene profilings 27 and 9 tissues using 7.5K human cDNA microarrays in indirect design with Yonsei reference RNA composed 11 line RNAs were done. The significant genes selected analysis microarray sets data. validated real-time PCR analysis. Results: After intensity-dependent, within-print-tip normalization by loess...

BACKGROUND: The aim of this study was to evaluate the subjective and objective olfactory function in coronavirus disease 2019 (COVID-19) patients effect training. METHODS: A prospective cohort performed 53 who recovered from COVID-19 visited our tertiary hospital. Subjective evaluated using 11-point Likert scale (0-10) Korean version Questionnaire Olfactory Disorders (QOD). Objective Cross-Cultural Smell Identification Test (CC-SIT). Confirmed were followed up after 2 months RESULTS: median,...

Background Radionecrosis is a complication of nasopharyngeal carcinoma (NPC) that difficult to treat. Endoscopic debridement the first-line treatment for radionecrosis. After debridement, however, either bone or internal carotid artery exposed and requires mucosal coverage. Objectives This study sought demonstrate effectiveness nasoseptal flap (NSF) after endoscopic radionecrosis in reconstruction ofnasopharyngeal skull base defects. Methods Nine patients with NPC who underwent...

Improvements in sleep-related quality of life (QOL) and behavioral problems have been observed children with obstructive sleep apnea (OSA) during a short-term follow-up after adenotonsillectomy. Whether this trend continues beyond the short term remains unclear. Therefore, we aimed to evaluate long-term effects surgery OSA.The study participants comprised 20 OSA who underwent We used scores from Attention Deficit Hyperactivity Disorder Rating Scale (ADHD-RS) total Korean OSA-18 Survey...

Objectives The aim of this study was to assess the sleep quality and stability according severity obstructive apnea (OSA) by using questionnaires cardiopulmonary coupling (CPC) analysis. Methods Two hundred twenty‐one adults were evaluated subjective questionnaires, CPC parameters, respiratory parameters measured during full‐night polysomnography. We differences in each OSA group correlation between apnea–hypopnea index (AHI) parameters. Results AHI not associated with questionnaires. is...