A5056041975- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Cardiac Structural Anomalies and Repair
- Lung Cancer Research Studies
- Mechanical Circulatory Support Devices
- Neuroendocrine Tumor Research Advances
- Cancer Immunotherapy and Biomarkers
- Cardiac Arrest and Resuscitation
- Tracheal and airway disorders
- Radiomics and Machine Learning in Medical Imaging
- Congenital Diaphragmatic Hernia Studies
- Esophageal Cancer Research and Treatment
- Cardiac Valve Diseases and Treatments
- Angiogenesis and VEGF in Cancer
- Pleural and Pulmonary Diseases
- Peptidase Inhibition and Analysis
- Medical Imaging Techniques and Applications
- Esophageal and GI Pathology
- Mesenchymal stem cell research
- Head and Neck Cancer Studies
- Medical Imaging and Pathology Studies
- Peripheral Artery Disease Management
- Congenital Anomalies and Fetal Surgery
- Ultrasound in Clinical Applications
Samsung Medical Center
2016-2025
Sungkyunkwan University
2016-2025
Yonsei University
2024-2025
Severance Hospital
2024-2025
Samsung (South Korea)
2015-2023
Samsung (United Kingdom)
2020
Digital Health Cooperative Research Centre
2020
Gyeongsang National University
2017
Changwon National University
2015
Samsung Changwon Hospital
2015
Recent studies have reported the predictive and prognostic value of novel transcriptional factor-based molecular subtypes in small-cell lung cancer (SCLC). We conducted an in-depth analysis pairing multi-omics data with immunohistochemistry (IHC) to elucidate underlying characteristics associated differences clinical outcomes between subtypes.
Venoarterial extracorporeal membrane oxygenation (VA ECMO) is widely used in patients with cardiogenic shock. Insufficient decompression of the left ventricle (LV) considered a major factor preventing adequate LV recovery. A 40-year-old male was diagnosed acute myocardial infarction, and revascularization performed using percutaneous stenting. However, shock occurred, VA ECMO initiated. Severe failure developed, transaortic catheter venting (TACV) incorporated into venous circuit under...
Extracorporeal membrane oxygenation (ECMO) has become one of the often applied mechanical support for acute cardiogenic shock. During venoarterial (VA) ECMO support, left heart decompression should be considered when ventricular (LV) distension develops with pulmonary edema and LV dysfunction. The aim this study was to report results transaortic catheter venting (TACV), as an alternative method, performed during VA-ECMO in patients We retrospectively reviewed records seven who underwent both...
Extended sleeve lobectomy (ESL), an atypical bronchoplasty with resection of more than 1 lobe, might be technically demanding but has certain theoretical advantages, including the avoidance pneumonectomy. However, clinical outcomes after ESL are not well known.Between March 1995 and December 2015, 540 patients centrally located non-small-cell lung cancer underwent resection. Among them, 63 procedure. We retrospectively analysed those in terms hospital mortality, postoperative complications...
Aims Programmed death‐ligand 1 (PD‐L1) expression is a predictive biomarker for adjuvant immunotherapy and has been linked to poor differentiation in lung adenocarcinoma. However, its prevalence prognostic role the context of novel histologic grade not evaluated. Methods We analysed cohort 1233 patients with resected adenocarcinoma where PD‐L1 immunohistochemistry (22C3 assay) was reflexively tested. Tumour correlated new standardized International Association Study Lung Cancer (IASLC)...
The aim of this study was to identify risk factors associated with mortality in patients re-admitted an intensive care unit (ICU) after initial recovery from major lung resection.We retrospectively reviewed the case records all who underwent resection between February 2011 and May 2013. A total 1916 surgery for various diseases, 63 (3.3%) which required ICU admission recovery. We analyzed preoperative perioperative data, including outcomes.The patient group included 57 men (90.5%) a mean age...
A certain proportion of non-small cell lung cancer (NSCLC) with activating EGFR mutations showed resistance to tyrosine kinase inhibitors (TKIs) by transforming their histology into small (SCLC). In this study, we evaluated the molecular characteristics transformed SCLCs.Eighteen SCLC tissue samples after TKI treatment were used for analysis. Immunohistochemistry was conducted evaluate subtype using antibodies representative major transcriptional factor-based subtypes, ASCL1 (SCLC-A),...
Accurate diagnostic criteria for tumor invasion are essential precise pathologic (pT) staging. Recently, the International Association Study of Lung Cancer (IASLC) Pathology Committee suggested a new set assessing invasion, but clinical usefulness proposed has not been evaluated.
In refractory cardiogenic shock, veno-arterial extracorporeal membrane oxygenation (ECMO) can be initiated. Although left heart decompression accomplished by insertion of a atrial (LA) or ventricular (LV) cannula using percutaneous pigtail catheter, the venting flow rate according to catheter size and ECMO is unknown. We developed an artificial circuit. One liter saline bag with its pressure set 20 mm Hg was connected mimic LV failure. A inserted into 1 L simulate unloading. For each (5–8...
Background Tumor mutational burden (TMB) measurement is limited by low tumor purity of samples, which can influence prediction the immunotherapy response, particularly when using whole-exome sequencing-based TMB (wTMB). This issue could be overcome targeted panel (pTMB) with higher depth coverage, remains unexplored. Methods We comprehensively reanalyzed four public datasets immune checkpoint inhibitor (ICI)-treated cohorts (adopting pTMB or wTMB) to test each biomarker’s predictive ability...
IntroductionThis study aimed to evaluate the value of programmed death-ligand 1 (PD-L1) copy number (CN) alteration as an additional biomarker standard immunohistochemistry (IHC) in predicting response immune checkpoint inhibitor (ICI) therapy advanced NSCLC.MethodsBefore ICI monotherapy, tumor PD-L1 CN (gain, neutral, or loss) was called using whole-exome sequencing data and compared with IHC results (tumor proportion score ≥50, 1–49, 0). Progression-free survival (PFS) overall were...
The aim of the study was to evaluate clinical outcomes patients with lung cancer in whom left ventricular ejection fraction (LVEF) reduced.A total 9814 who underwent pulmonary resection from 2010 2018 were included for study. Fifty-six (0.57%) had LVEFs ≤45% and we performed propensity score matching (1:3) compare postoperative survival 56 (reduced LVEF group) those 168 normal (nonreduced group).The data reduced group nonreduced matched compared. 30- (1.8%) 90-day (7.1%) mortality rates...