A5052573829- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Fatty Acid Research and Health
- Apelin-related biomedical research
- Hormonal Regulation and Hypertension
- Biochemical effects in animals
- Lipid metabolism and biosynthesis
- Surgical Simulation and Training
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Synthesis of Organic Compounds
- Cardiac, Anesthesia and Surgical Outcomes
- Gestational Diabetes Research and Management
- Spaceflight effects on biology
- Pancreatic and Hepatic Oncology Research
- Ocular Oncology and Treatments
- Muscle metabolism and nutrition
- Glaucoma and retinal disorders
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Adolescent and Pediatric Healthcare
- Pregnancy and preeclampsia studies
- Prenatal Substance Exposure Effects
- Synthesis and biological activity
- Breastfeeding Practices and Influences
- Heme Oxygenase-1 and Carbon Monoxide
Princess Margaret Cancer Centre
2025
Viet Duc Hospital
2019-2024
HonorHealth
2024
McGill University
2018-2023
University of Toronto
2020-2023
Hanoi Medical University
2023
Montreal Children's Hospital
2023
Ministry of Health
2021-2022
Health Strategy and Policy Institute
2022
Health Net
2022
Neuronal uncoupling proteins (UCP2, UCP4, and UCP5) have crucial roles in the function protection of central nervous system (CNS). Extensive biochemical studies UCP2 provided ample evidence its participation proton anion transport. To date, functional UCP4 UCP5 are scarce. In this study, we show for first time that, despite a low level amino acid sequence identity with previously characterized UCPs (UCP1-UCP3), share their properties. Recombinantly expressed Escherichia coli, UCP2, were...
The nitrocatechol derivatives tolcapone (1) and entacapone (2), used as adjunctive therapy in the treatment of Parkinson's disease, were investigated for their potential to inhibit tau-derived-hexapeptide 306VQIVYK311. They compared small molecules that contain similar pharmacophores including catechol (dopamine 3 epinephrine 4), nitroderivatives (nifedipine 5 chloramphenicol 6), isomers (7 8), a derivative (13) lacking moiety. aggregation kinetics by thioflavin S fluorescence assay...
Cationic antimicrobial peptides are promising sources for novel therapeutic agents against multi-drug-resistant bacteria. HHC-36 (KRWWKWWRR) is a simple but effective peptide with similar or superior activity compared several conventional antibiotics. In this biophysical study, unique conformational properties of and some its analogs as well interaction lipid membranes investigated in detail. Circular dichroism (CD) molecular dynamics modeling studies different environments reveal dynamic...
The protection of personal data in the banking sector has become a critical issue context digitalization and increasing cybersecurity risks. Many countries have established strict legal frameworks to safeguard customer information, ensuring transparency security financial activities. Using synthesis documents an analytical approach, this paper examines framework for United States, European Union (EU), Japan, drawing relevant lessons Vietnam. Based on analysis, proposes several solutions...
To improve maternal and neonatal outcomes, Vietnam implemented early essential newborn care (EENC) using clinical coaching quality improvement self-assessments in hospitals to introduce policy, practice environmental changes. Da Nang Hospital for Women Children began EENC with caesarean section births inform development of national guidelines. This study compared outcomes after sections pre/post-EENC introduction.
Mitochondrial uncoupling proteins of the nervous system (UCPs 2, 4, and 5) have potential roles in function protection central (CNS). In absence structural information, conformations hexahistidine-tagged versions all five human UCPs liposomes were investigated for first time, using far- near-UV CD fluorescence spectroscopy. Highly pure 1−5 reconstituted detergents stable small unilamellar vesicles, appropriate spectroscopic studies. All formed dominantly helical negatively charged...
Abstract Background Medical student demands for competency based homeless health education is increasing. Indeed, humans living a treatable and social emergency. This innovation report outlines the initial development of an framework health. Methods A medical task force educators conducted mixed method study, including scoping review curriculum competencies, cross-country survey students, unique clinical guidelines. The collaborated with persons lived experience guideline developers from...
Mitochondrial inner membrane uncoupling proteins (UCPs) facilitate transmembrane (TM) proton flux and consequently reduce the potential ATP production. It has been proposed that three neuronal human UCPs (UCP2, UCP4 UCP5) in central nervous system (CNS) play significant roles reducing cellular oxidative stress. However, structure ion transport mechanism of these remain relatively unexplored. Recently, we reported a novel expression for obtaining functionally folded UCP1 bacterial membranes...
Background: African swine fever (ASF) is an important disease affecting and has a significant economic loss in both the developed developing world.Aim: In this study, we evaluated potential effects of medium-chain fatty acids (MCFAs) individual synergistic forms to prevent and/or reduce ASF virus (ASFV) infection using vitro feed model. Methods:The cytotoxicity MCFAs on porcine alveolar macrophages cells was by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.The MCFAs,...
The prevalence of early and exclusive breastfeeding in Vietnam remains sub-optimal. objective this study was to determine factors associated with initiation (EIBF) for the first 3 days after birth (EBF3D). We conducted a population-based, cross-sectional survey 726 mothers children aged 0–11 months two provinces one municipality from May July 2020. Multinomial logistic regression used examine EIBF EBF3D. 39.7% EBF3D 18.0%. is positively immediate uninterrupted skin-to-skin contact (SSC)...
Residing at the inner mitochondrial membrane, uncoupling protein-2 (UCP2) mediates proton transport from intermembrane space (IMS) to matrix and consequently reduces rate of ATP synthesis in mitochondria. The ubiquitous expression UCP2 humans can be attributed protein's multiple physiological roles tissues, including its involvement protective mechanisms against oxidative stress, as well glucose lipid metabolisms. Currently, structural properties ion mechanism other UCP homologues remain...
Abstract Objective: To evaluate the utility of autologous bone-flap swab cultures performed at time cranioplasty in predicting postcranioplasty surgical site infection (SSI). Design: Retrospective cohort study. Participants: Patients undergoing craniectomy (with storage tissue bank), followed by delayed replacement between January 1, 2010, and November 30, 2020. Setting: Tertiary-care academic hospital. Methods: We framed culture taken as a diagnostic test for SSI. calculated, sensitivity,...
The Arabidopsis thaliana protein atTic20 is a key component of the import machinery at inner envelope membrane chloroplasts. As TIC complex, it believed to form preprotein-conducting channel across membrane.We report method for producing large amounts recombinant using codon-optimized strain E. coli coupled with an autoinduction expression. This resulted in being directed bacterial without addition targeting sequence. Using biochemical and biophysical approaches, we were able demonstrate...
Surgical and simulation development have always been closely associated with military activity. The last ten years continued that trend, allowing for training in real time, under reality-based conditions, learning technical clinical skills the dynamic of true human factors team actual environment. We present data from diverse activities three separate scenarios: second-year medical students scenarios; U.S. Ski Team physicians austere conditions; Navy Fleet sea land deployment.
Abstract Iron homeostasis is an essential biological process that ensures the tissue distribution of iron for various cellular processes. As major producer hepcidin, liver central to regulation metabolism. The also home many immune cells, which upon activation may greatly impact Here, we focus on role invariant natural killer T (iNKT) a subset lymphocytes that, in mice, most abundant liver. Activation iNKT cells with prototypical glycosphingolipid antigen, α-galactosylceramide, resulted cell...