A5019785710- Polyamine Metabolism and Applications
- Amino Acid Enzymes and Metabolism
- Semiconductor materials and devices
- Advancements in Semiconductor Devices and Circuit Design
- FOXO transcription factor regulation
- Silymarin and Mushroom Poisoning
- Biotin and Related Studies
- Energy Efficient Wireless Sensor Networks
- Hormonal Regulation and Hypertension
- Signaling Pathways in Disease
- Biochemical Acid Research Studies
- Curcumin's Biomedical Applications
- Silicon Carbide Semiconductor Technologies
- Context-Aware Activity Recognition Systems
- Ubiquitin and proteasome pathways
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer-related gene regulation
- Melamine detection and toxicity
- Cancer Mechanisms and Therapy
- Macrophage Migration Inhibitory Factor
- Nuclear Receptors and Signaling
- Nanowire Synthesis and Applications
- Bioactive Compounds in Plants
- Skin Protection and Aging
- Security in Wireless Sensor Networks
Seoul National University
2011-2024
University of Wisconsin–Madison
2022
Hormel (United States)
2008-2019
University of Minnesota
2008-2019
Kyung Hee University
2002-2018
Hankuk University of Foreign Studies
2015
Hallym University
2010-2014
Kangwon National University
2014
Cancer Research Institute
2013
Keimyung University
2013
As the network communications technology developing, a new type of networks has appeared in daily life which is named underwater sensor (UWSNs). UWSNs are class emerging that experience variable and high propagation delays limited available bandwidth. There comprehensive applications this area such as oceanographic data collection, pollution monitoring, offshore exploration, assisted navigation so on. Due to different environment under ocean, routing protocols should be re-designed fit for...
Cloud storage is now a hot research topic in information technology. In cloud storage, date security properties such as data confidentiality, integrity and availability become more important many commercial applications. Recently, provable possession (PDP) schemes are proposed to protect integrity. some cases, it has delegate the remote checking task proxy. However, these PDP not secure since proxy stores state servers. Hence, this paper, we propose an efficient mutual verifiable scheme,...
For the first time, we have successfully fabricated gate-all-around twin silicon nanowire transistor (TSNWFET) on bulk Si wafer using self-aligned damascene-gate process. With 10nm diameter nanowire, saturation currents through nanowires of 2.64 mA/mum, 1.11 mA/mum for n-channel TSNWFET and p-channel are obtained, respectively. No roll-off threshold voltages, ~70 mV/dec. substhreshold swing (SS), ~20 mV/V drain induced barrier lowering(DIBL) down to 30 nm gate length observed both n-ch p-ch TSNWFETs
Somatic cells can be reprogrammed into induced pluripotent stem (iPSCs) by transduction of reprogramming factors, including Oct4, Sox2, Klf4, and c-Myc. A coordinated network these factors was suggested to confer a pluripotency iPSCs. Together with Sox2 plays major role as master regulator in ESCs. However, the underlying mechanisms which contributes self-renewal or processes remain determined. Here, we provide new evidence for phosphorylation-based regulation activity. Akt directly...
During the metastatic phase, cancer cells require dissolution of cadherin-mediated cell-cell adhesion and a dramatic re-organization cytoskeleton through epithelial-mesenchymal transition (EMT), thereby acquiring migratory invasive capabilities. In most tumors, EMT is accompanied by hypoxia. However, intracellular signaling molecule that mediates hypoxia-induced remained overlooked. By utilizing microarray database system Cancer Genome Atlas, we identified ubiquitin-specific protease 47...
The ζ chain-associated 70-kDa protein (ZAP-70) of tyrosine kinase plays a critical role in T cell receptor-mediated signal transduction and the immune response. A high level ZAP-70 expression is observed leukemia, which suggests as logical target for immunomodulatory therapies. (-)-Epigallocatechin gallate (EGCG) one major green tea catechins that suggested to have preventive agent cancer, obesity, diabetes, cardiovascular disease. Here we identified an important novel molecular EGCG...
Abstract Abnormal functioning of multiple gene products underlies the neoplastic transformation cells. Thus, chemopreventive and/or chemotherapeutic agents with multigene targets hold promise in development effective anticancer drugs. Silybin, a component milk thistle, is natural agent. In present study, we investigated effect silybin on melanoma cell growth and elucidated its molecular targets. Our study revealed that attenuated xenograft tumors nude mice. Silybin inhibited kinase activity...
The aim of this study was to investigate the skin anti-inflammatory activity rose petal extract (RPE) and mechanisms underlying phenomenon. Recently, flowers have been considered as dietary resources owing their biological activities, such inhibition nephritis hemorrhoids. Rosa plant exerts various functions, including antioxidant anti-microbiological activities. Herein, we confirmed RPE upon solar UV (sUV) exposure. reduced sUV-induced COX-2 expression well expressions several cytokines....
Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis that associated with cell growth and tumor formation. Existing catalytic inhibitors ODC have lacked efficacy clinical testing or displayed unacceptable toxicity. In this study, we report identification an effective nontoxic allosteric inhibitor ODC. Using computer docking simulation vitro assay, identified herbacetin, natural compound found flax other plants, as novel inhibitor. Mechanistic...
We have demonstrated a novel three-dimensional multibridge-channel metal-oxide-semiconductor field-effect transistor (MBCFET). This was successfully fabricated using conventional complementary process. introduce the fabrication technologies and electrical characteristics of MBCFET in comparison with planar MOSFET. The has more benefits than It shows 4.6 times larger current drivability is due to vertically stacked multibridge channels. subthreshold swing 61 mV/dec, which almost an ideal...
In recent years, much research in the field of data dissemination protocols to mobile sinks, for wireless sensor networks, has been published. Such inspire us design CODE, a coordination-based protocol networks. CODE considers energy efficiency and network lifetime, especially networks with high node density. is based on grid structure establish an efficient path between sources mobiles sinks. Our simulation results show that consumes less longer lifetime compared other approaches.
A gate-all-around (GAA) twin silicon nanowire MOSFET (TSNWFET) with 5-nm-radius channels on a bulk Si wafer is successfully fabricated to achieve extremely high-drive currents of 2.37 mA/ mum for n-channel and 1.30 p-channel TSNWFETs mid-gap TiN metal gate that are normalized by diameter. It also shows good short-channel effects immunity down 30-nm length due the GAA structure channel. The effect bottom parasitic transistor in TSNWFET investigated.
In recent years, due to the appealing features of cloud computing, more and sensitive or private information has been outsourced onto cloud. Although computing provides convenience, privacy security data becomes a big concern. For protecting privacy, it is desirable for owner outsource in encrypted form rather than plain text. However, storage will hinder our legal access, e.g., searching function. To deal with this dilemma, considerable number searchable encryption schemes have proposed...
Uncertainty always exists as an unavoidable factor when developing context-aware applications for pervasive computing environments. In this paper, we propose a unified context model to support representation and reasoning about uncertain context. Our extends the existing, de-facto ontology-based models with probabilistic reasoning. Especially, our can be easily integrated existing systems. Given model, ontology built used frameworks in aware applications. Besides, recipe of supporting is...
Important applications of Wireless Ad Hoc Networks make them very attractive to attackers, therefore more research is required guarantee the security for Networks. In this paper, we proposed a transmission time based mechanism (TTM) detect wormhole attacks - one most popular & serious in TTM detects during route setup procedure by computing between every two successive nodes along established path. Wormhole identified base on fact that fake neighbors created considerably higher than real...
The c-Jun N-terminal kinase (JNK) signaling pathway is known to mediate both survival and apoptosis of tumor cells. Although JNK1 JNK2 have been shown differentially regulate the development skin cancer, underlying mechanistic basis remains unclear. Here, we demonstrate that JNK1, but not JNK2, interacts with phosphorylates Myt1 ex vivo in vitro. UVA induces substantial JNK wild-type (JNK(+/+)) or JNK2-deficient (JNK2(-/-)) mouse embryonic fibroblasts has no effect on JNK1-deficient...
In recent years, many energy efficient algorithms and routing protocols have been proposed for wireless sensor networks (WSNs) with the object to balance consumption maximize network lifetime. It has proved that utilizing clustering technique adding sink mobility into can bring in new opportunities improve efficiency WSNs. Glowworm Swarm Optimization (GSO), which belongs swarm intelligence field inspired by simulated experiments of lighting worms' behavior, is also an effective method...
Kaempferia parviflora (Krachaidum (KD)) is a traditional herbal medicine and has properties that are beneficial for human health. In the current study, we sought to investigate anti‐inflammatory of KD extract (KPE). mouse skin tissue, UV light representing solar wavelengths (sUV) increased COX‐2 expression, while treatment with KPE reduced this effect. The activity was confirmed in vitro models. MAPK signaling pathways were activated by sUV irradiation, also repressed presence treatment. It...
Yak-Kong (YK) is a small black soybean widely cultivated in Korea. It considered to have excellent health functionality, as it has been reported better antioxidant efficacy than conventional or yellow soybeans. Since YK described good for the muscle of elderly old oriental medicine books, this study sought investigate effect fermented with Bifidobacterium animalis subsp. lactis LDTM 8102 (FYK) on atrophy. In C2C12 mouse myoblasts, FYK elevated expression MyoD, total MHC, phosphorylated AKT,...
We have successfully fabricated sub 30nm N+ poly and TiN gate MBCFET (multi-bridge-channel field effect transistor) both on SOI wafers bulk-Si wafers. Using metal 20nm multi bridge channels, we achieved the drive current of 2.3mA//spl mu/m that is largest ever reported for pMOSFETs with excellent subthreshold swing 75mV/dec, drain induce barrier lowering (DIBL) 36mV/V. Large I/sub on//I/sub off/ ratio threshold voltage (V/sub t/) distribution were obtained using to eliminate channel ion...