A5084814512- Forest Management and Policy
- Forest Ecology and Biodiversity Studies
- Land Use and Ecosystem Services
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Conservation, Biodiversity, and Resource Management
- Ecology and Vegetation Dynamics Studies
- RNA modifications and cancer
- Tree-ring climate responses
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Genetics and Physical Performance
- Epigenetics and DNA Methylation
- Animal Genetics and Reproduction
- Diet, Metabolism, and Disease
- Gene expression and cancer classification
- Water Resources and Management
- Wildlife Ecology and Conservation
- Sports Performance and Training
- Reproductive System and Pregnancy
- Marketing and Advertising Strategies
- Muscle metabolism and nutrition
- Molecular Biology Techniques and Applications
- Bioinformatics and Genomic Networks
- Economic and Technological Systems Analysis
University of Inland Norway
2019-2024
Hong Kong Science and Technology Parks Corporation
2024
Russian State Agrarian University - Moscow Timiryazev Agricultural Academy
2020-2023
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
2016-2021
Ministry of Health of the Russian Federation
2020
Swedish University of Agricultural Sciences
2013-2019
Federal Research and Clinical Center of Physical-Chemical Medicine named after Y.M. Lopukhin
2013-2017
Federal Medical-Biological Agency
2012
Abstract Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at the clinical level. We identify TRAF2- and NCK-interacting kinase (TNIK) as anti-fibrotic target using predictive artificial intelligence (AI) approach. Using AI-driven methodology, we generated INS018_055, small-molecule TNIK inhibitor, which exhibits desirable drug-like properties activity...
Illumina's Infinium HumanMethylation450 BeadChip arrays were used to examine genome-wide DNA methylation profiles in 22 sample pairs from colorectal cancer (CRC) and adjacent tissues 19 colon tissue samples cancer-free donors. We show that the of tumors healthy can be clearly distinguished one another main source variability is associated with disease status. different statistical approaches evaluate data. In general, at CpG-site level, we found common CRC-specific patterns consist least...
Policies at multiple levels pronounce the need to encompass both social and ecological systems in governance management of natural capital terms resources ecosystems. One approach knowledge production learning about landscapes as social–ecological is compare case studies consisting large spaces places. We first review landscape concepts' biophysical, anthropogenic, intangible dimensions. Second, we exemplify how different concepts can be used derive measurable variables for sustainability...
The definition of DNA and RNA G-quadruplexes (G4s) has recently been broadened to include structures with certain defects: bulges, G-vacancies or mismatches. Despite the striking progress in computational methods for assessing G4 folding propensity, predicting G4s defects remains problematic, reflecting enhanced sequential diversity these motifs. "Imperfect" motifs, i.e., those containing interrupted truncated G-runs, are typically omitted from genomic analyses. We report here studies...
To investigate the association between multiple single-nucleotide polymorphisms (SNPs), aerobic performance and elite endurance athlete status in Russians. By using GWAS approach, we examined 1,140,419 SNPs relative maximal oxygen consumption rate ([Formula: see text]O2max) 80 international-level Russian athletes (46 males 34 females). validate obtained results, further performed case-control studies by comparing frequencies of most significant (with P < 10(-5)-10(-8)) 218 opposite cohorts...
The MGISEQ-2000 developed by MGI Tech Co. Ltd. (a subsidiary of the BGI Group) is a new competitor such next-generation sequencing platforms as NovaSeq and HiSeq (Illumina). Its principle based on DNB cPAS technologies, which were also used in previous version BGISEQ-500 device. However, reagents for have been refined platform utilizes updated software. method an advanced technology cPAL previously created Complete Genomics. In this paper, authors compare results whole-genome DNA sample from...
Abstract The policy term green infrastructure highlights the need to maintain functional ecosystems as a foundation for sustainable societies. Because forests are main natural in Europe, it is crucial understand extent which forest landscape management delivers infrastructures. We used steep west–east gradient history, land ownership, and political culture within northern Europe's Baltic Sea Region assess regional profiles of benefits delivered by landscapes. aim was support policy‐makers...
Abstract We present a multimodal multi-species multi-omics multi-tissue transformer for aging research and drug discovery capable of performing multiple tasks such as age prediction across species, target discovery, tissue, sex, disease sample classification, sensitivity prediction, replication omics response biological phenotypic to compound treatment. This model combines textual, tabular, knowledge graph-derived representations experiments provide insights into molecular-level processes....
Modern goal-oriented scientific research process involves hierarchical teams of researchers diverse backgrounds performing generalist and domain-specific tasks. Many these tasks include hypothesis generation, literature review, data collection, cleanup, processing analysis, experimental design, virtual physical experiments, report academic paper writing, reference management, bibliography quality control. Most can be performed automatically or in a co-pilot mode by the generative...
Muscle fibre type is a heritable trait and can partly predict athletic success. It has been proposed that polymorphisms of genes involved in the regulation muscle characteristics may predispose precursor cells given individual to be predominantly fast or slow. In present study, we examined association between 15 candidate gene composition vastus lateralis 55 physically active, healthy men. We found rs11091046 C allele carriers angiotensin II 2 receptor (AGTR2; skeletal development,...
Exercise-induced oxidative stress is a state that primarily occurs in athletes involved high-intensity sports when pro-oxidants overwhelm the antioxidant defense system to oxidize proteins, lipids, and nucleic acids. During exercise, linked muscle metabolism damage, because exercise increases free radical production. The T allele of Ala16Val (rs4880 C/T) polymorphism mitochondrial superoxide dismutase 2 (SOD2) gene has been reported reduce SOD2 efficiency against stress. In present study we...
The pluripotency of newly developed human induced pluripotent stem cells (iPSCs) is usually characterized by physiological parameters; i.e., their ability to maintain the undifferentiated state and differentiate into derivatives 3 germ layers. Nevertheless, a molecular comparison physiologically normal iPSCs "gold standard" pluripotency, embryonic (ESCs), often reveals set genes with different expression and/or methylation patterns in ESCs. To evaluate contribution reprogramming process,...
Advanced paternal age at fertilization is a risk factor for multiple disorders in offspring and may be linked to age-related epigenetic changes the father’s sperm. An understanding of aging-related sperm environmental factors that modify such needed. Here, we characterize small non-coding RNA (sncRNA) between young pubertal mature rats. We also analyze modification these by exposure xenobiotic 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47). sncRNA libraries prepared from epididymal spermatozoa...
Perinatal exposures to polybrominated diphenyl ethers permanently reprogram liver metabolism and induce a nonalcoholic fatty disease-like phenotype insulin resistance in rodents. Aim: To test if these changes are associated with altered epigenome. Materials & methods: Expression of small RNA DNA methylation livers adult rats were analyzed following perinatal exposure 2,2',4,4'-tetrabromodiphenyl ether, the ether congener most prevalent human tissues. Results: We identified 33 differentially...
Abstract Grassland ecosystems are species-rich habitats that rapidly declining globally posing serious concerns for biodiversity conservation. This situation is particularly relevant in agricultural areas Europe. As traditional management practices and livestock grazing regimes ceased, rewilding could be a potential avenue to tackle current declines. To test this hypothesis, we set up 3-year experiment where 12 horses were introduced three 10-hectare enclosure replicates (four per...
Land use and landcover change alter the ability of habitat networks to maintain viable species populations. While their effects on quality, amount patterns patches are commonly studied, how they affect ecological processes, such as predation focal remains neglected. This macroecological study tests hypothesis that predator assemblages affected by land intensity linked different socio-economic contexts. We measured distribution abundance two avian groups (generalist corvid birds specialist...
Russian forest policy stipulates that intensified wood production is part of sustainable management. Swedish practices form a role model for this ambition. However, are the biophysical conditions tree growth same in northwest (NW) Russia and Sweden? We compared rates young Scots pine (Pinus silvestris L.) Norway spruce (Picea abies H. Karst.) at 58°, 60°, 62°, 64°N both countries. Stands on rich, mesic poor sites were sampled using intercept method as an indicator actual rate. Young did not...
To determine the most informative markers for assessing functional state of endometrium during 'window implantation' and creating a model assessment readiness embryo implantation. Forty-seven women with tubal infertility successful IVF pregnancy participated in study. Pipelle endometrial sample was performed supposed natural cycle subsequent histological study, transcriptional profile genes GPX3, PAEP, DPP4, TAGLN, HABP2, IMPA2, AQP3, HLA-DOB, MSX1, POSTN determined by real-time quantitative...
Spatial segregation of different forest landscape functions can accommodate rival forestry objectives more comprehensively than integrated approaches. Russia has a unique history zoning separating production and environmental functions. However, the Russian Forest Code 2006 increased focus on wood production. We reviewed policy in assessed if recent change affected logging rates conservation riparian forests. Using Russia’s Komi Republic as case study, we specifically (i) led to near...