A5035703723- Ion Channels and Receptors
- Thermoregulation and physiological responses
- Neurobiology and Insect Physiology Research
- Bioactive Compounds and Antitumor Agents
- Pain Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- Computational Drug Discovery Methods
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Scientific Computing and Data Management
- Respiratory and Cough-Related Research
- Bone Metabolism and Diseases
- Pharmaceutical Economics and Policy
- Asthma and respiratory diseases
- Animal testing and alternatives
- Cancer, Stress, Anesthesia, and Immune Response
- Nicotinic Acetylcholine Receptors Study
- Redox biology and oxidative stress
- Drug Transport and Resistance Mechanisms
- vaccines and immunoinformatics approaches
- Stress Responses and Cortisol
- Bioinformatics and Genomic Networks
- Sodium Intake and Health
- Phytochemicals and Antioxidant Activities
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
King's College London
2009-2021
Imperial College London
2019
British Heart Foundation
2015-2017
Novo Nordisk (Denmark)
2017
Nephrologisches Zentrum Goettingen
2017
Glostrup Hospital
2017
Rigshospitalet
2017
St Thomas' Hospital
2017
The cold-induced vascular response, consisting of vasoconstriction followed by vasodilatation, is critical for protecting the cutaneous tissues against cold injury. Whilst this physiological reflex response historic knowledge, mechanisms involved are unclear. Here using a murine model local environmental exposure, we show that TRPA1 acts as primary sensor, determined through pharmacological antagonism or gene deletion. initial mediated via TRPA1-dependent superoxide production stimulates...
Background Reliable measurement of blood pressure in conscious mice is essential cardiovascular research. Telemetry, the “gold‐standard” technique, invasive and expensive therefore tail‐cuff, a noninvasive alternative, widely used. However, tail‐cuff requires handling restraint during measurement, which may cause stress affecting undermining reliability results. Methods Results C57Bl/6J were implanted with radio‐telemetry probes to investigate effects steps technique on central pressure,...
Research into the therapeutic potential of α-calcitonin gene-related peptide (α-CGRP) has been limited because its nature and short half-life. Here, we evaluate whether a novel potent long-lasting (t½ ≥7 hours) acylated α-CGRP analogue (αAnalogue) could alleviate reverse cardiovascular disease in 2 distinct murine models hypertension heart failure vivo.The ability αAnalogue to act selectively via CGRP pathway was shown skin by using receptor antagonist. The effect on angiotensin II-induced...
Transient receptor potential canonical 5 (TRPC5) is functionally expressed on a range of cells including fibroblast-like synoviocytes, which play an important role in arthritis. A for TRPC5 inflammation has not been previously shown vivo. We investigated the contribution Male wild-type and knockout (KO) mice were used complete Freund's adjuvant (CFA)-induced unilateral arthritis model, assessed over 14 days. Arthritis was determined by measurement knee joint diameter, hindlimb weightbearing...
Transient receptor potential vanilloid 1 (TRPV1) is involved in sensory nerve nociceptive signaling. Recently, it has been discovered that TRPV1 receptors also regulate basal body temperature multiple species from mice to humans. In the present study, we investigated whether modulates sympathetic nervous system (SNS) activity. C57BL6/J wild-type (WT) and knockout (KO) were implanted with radiotelemetry probes for measurement of core temperature. AMG 9810∗∗∗ (50 mg/kg) or vehicle (2% DMSO/5%...
Abstract We present a multimodal multi-species multi-omics multi-tissue transformer for aging research and drug discovery capable of performing multiple tasks such as age prediction across species, target discovery, tissue, sex, disease sample classification, sensitivity prediction, replication omics response biological phenotypic to compound treatment. This model combines textual, tabular, knowledge graph-derived representations experiments provide insights into molecular-level processes....
Modern goal-oriented scientific research process involves hierarchical teams of researchers diverse backgrounds performing generalist and domain-specific tasks. Many these tasks include hypothesis generation, literature review, data collection, cleanup, processing analysis, experimental design, virtual physical experiments, report academic paper writing, reference management, bibliography quality control. Most can be performed automatically or in a co-pilot mode by the generative...
: Hepatitis B virus (HBV) and C (HCV) contribute significantly to morbidity mortality among drug users in Asia. This study systematically reviews analyzes the pooled prevalence of HBV HCV, considering geographic methodological variations. A meta-analysis following PRISMA guidelines included data from PubMed, Scopus, Google Scholar on studies or HCV a combination both within random-effects model estimated prevalence, with subgroup analyses by region, design, diagnostic method, publication...
Osteo-arthritis (OA) involves joint degradation and usually pain; with mechanisms poorly understood few treatment options. There is evidence that the transient receptor potential canonical 5 (TRPC5) mRNA expression reduced in OA patients' synovia. Here we examine profile of TRPC5 DRG involvement murine models OA.TRPC5 KO mice were subjected to partial meniscectomy (PMNX) or injected monoiodoacetate (MIA) pain-related behaviours determined. Knee pathological scores analysed gene changes...
Breast cancer remains a significant health challenge, with estrogen receptor positive (ER+) subtypes being particularly prevalent forms of breast cancer. Current anti-estrogen therapies, such as tamoxifen and fulvestrant, have limitations, including partial agonist activity resistance development, which evidence the need for more potent alternatives. Endoxifen, metabolite tamoxifen, has emerged promising therapeutic candidate due to its superior anti-estrogenic effects side effect profile....
Thioredoxin plays an essential role in bacterial antioxidant machinery and virulence; however, its regulatory actions the host are less well understood. Reduced human Trx activates transient receptor potential canonical 5 (TRPC5) inflammation, but there is no evidence of whether these receptors mediate thioredoxin effects host. Importantly, TRPC5 can form functional complexes with other subunits such as TRPC4. Herein, E. coli ‐derived induced mortality lipopolysaccharide‐ (LPS‐) injected...
Abstract Transient receptor potential canonical 5 (TRPC5), a calcium-permeable, non-selective cation channel is expressed in the periphery, but there limited knowledge of its regulatory roles vivo . Endogenous modulators TRPC5 include range phospholipids that have an established role liver disease, including lysophosphatidylcholine (LPC). Cholestasis characterized by impairment excretion bile acids, leading to elevation hepatic acids. We investigated contribution murine model cholestasis....
Recently, we found that the deletion of TRPC5 leads to increased inflammation and pain-related behaviour in two animal models arthritis. (-)-Englerin A (EA), an extract from East African plant Phyllanthus engleri has been identified as a TRPC4/5 agonist. Here, studied whether or not EA any anti-inflammatory analgesic properties via carrageenan model inflammation. We treatment CD1 mice inhibited thermal hyperalgesia mechanical allodynia dose-dependent manner. Furthermore, significantly...
Dengue virus infection represents a major global health issue, with four distinct serotypes complicating the challenge of developing vaccine due to need for balanced, long-lasting immunity against all serotypes. Current vaccines have limitations, including an increased risk severe dengue in seronegative individuals and moderate efficacy, highlighting more effective solutions. Our study aimed design multi-serotype using computational approach achieve broad-spectrum immunity. We employed...
<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by inflammation of diarthrodial joints. Sensory neurons expressing transient receptor potential (TRP) channels, wide family non-selective cation have been shown to play role in the pathogenesis RA<sup>1</sup>. Transient 5 (TRPC5) member canonical TRPC channels and abundantly expressed central nervous system periphery<sup>2</sup>, including CD55<sup>+</sup> fibroblast-like synoviocytes<sup>3</sup>, but...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)