A5069263649- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Ion Channels and Receptors
- Nitric Oxide and Endothelin Effects
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hormonal Regulation and Hypertension
- Thermoregulation and physiological responses
- Hypothalamic control of reproductive hormones
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Ion channel regulation and function
- Neurobiology and Insect Physiology Research
- Stress Responses and Cortisol
- Heart Rate Variability and Autonomic Control
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Migraine and Headache Studies
- Regulation of Appetite and Obesity
- Psoriasis: Treatment and Pathogenesis
- Urticaria and Related Conditions
- Olfactory and Sensory Function Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Nerve injury and regeneration
King's College London
2016-2025
British Heart Foundation
2009-2024
University of California, Davis
2018
Sanford Health
2018
University of California, Irvine
2018
University of California, Los Angeles
2018
University of California, San Francisco
2018
University of California, San Diego
2018
Catalent (United States)
2018
Novo Nordisk (Denmark)
2014-2017
The potent vasodilator calcitonin gene‐related peptide (CGRP, human synthetic), when mixed with histamine and injected intradermally in the rabbit, induced a marked potentiation of local oedema. CGRP also potentiated oedema by other mediators increased microvascular permeability rabbit; bradykinin, platelet‐activating factor (Paf), C5a des Arg, N ‐formylmethionyl‐leucyl‐phenylalanine (FMLP) leukotriene B 4 (LTB ). Substance P alone, or mixtures substance CGRP, failed to induce rabbit skin....
To investigate the involvement of transient receptor potential ankyrin 1 (TRPA1) in inflammatory hyperalgesia mediated by tumor necrosis factor α(TNFα) and joint inflammation.Mechanical was assessed CD1 mice, mice lacking functional TRP vanilloid (TRPV1-/-) or TRPA1 (TRPA1-/-), respective wildtype (WT) mice. An automated von Frey system used, following unilateral intraplantar injection TNFα intraarticular Freund's complete adjuvant (CFA). Knee swelling histologic changes were determined...
The aim of the study is to investigate transient receptor potential ankyrin 1 (TRPA1)-induced responses in vasculature and on blood pressure heart rate (HR), response TRPA1 agonists using wild-type (WT) knockout (KO) mice. allyl isothiocyanate cinnamaldehyde (CA) significantly increased flow skin anaesthetized WT, but not KO CA also induced TRPA1-dependent relaxation mesenteric arteries. Intravenously injected a hypotensive accompanied by decreased HR that was, depending genotype dose,...
The cold-induced vascular response, consisting of vasoconstriction followed by vasodilatation, is critical for protecting the cutaneous tissues against cold injury. Whilst this physiological reflex response historic knowledge, mechanisms involved are unclear. Here using a murine model local environmental exposure, we show that TRPA1 acts as primary sensor, determined through pharmacological antagonism or gene deletion. initial mediated via TRPA1-dependent superoxide production stimulates...
The transient receptor potential vanilloid 1 (TRPV1) is primarily localized to sensory nerve fibers and associated with the stimulation of pain inflammation. TRPV1 knockout (TRPV1KO) mice show enhanced LPS-induced sepsis compared wild type (WT). This implies that may have a key modulatory role in increasing beneficial reducing harmful components sepsis. We investigated immune inflammatory mechanisms cecal ligation puncture (CLP) model over 24 h. CLP TRPV1KO exhibited significant hypothermia,...
α-Calcitonin gene-related peptide (αCGRP) is a vasodilator, but there limited knowledge of its long-term cardiovascular protective influence. We hypothesized that αCGRP protects against the onset and development angiotensin II-induced hypertension have identified mechanisms at vascular level. Wild-type knockout mice similar baseline blood pressure were investigated in II model for 14 28 days. exhibited enhanced aortic hypertrophy. gene expression was increased dorsal root ganglia conduit...
Background Reliable measurement of blood pressure in conscious mice is essential cardiovascular research. Telemetry, the “gold‐standard” technique, invasive and expensive therefore tail‐cuff, a noninvasive alternative, widely used. However, tail‐cuff requires handling restraint during measurement, which may cause stress affecting undermining reliability results. Methods Results C57Bl/6J were implanted with radio‐telemetry probes to investigate effects steps technique on central pressure,...
Research into the therapeutic potential of α-calcitonin gene-related peptide (α-CGRP) has been limited because its nature and short half-life. Here, we evaluate whether a novel potent long-lasting (t½ ≥7 hours) acylated α-CGRP analogue (αAnalogue) could alleviate reverse cardiovascular disease in 2 distinct murine models hypertension heart failure vivo.The ability αAnalogue to act selectively via CGRP pathway was shown skin by using receptor antagonist. The effect on angiotensin II-induced...