Background Histamine-releasing activity (HRA) is detectable in up to 50% of patients with chronic ordinary urticaria. Objectives To determine the effect cyclosporin on clinical features and HRA Methods Thirty severe unremitting disease, responding poorly antihistamines showing a positive autologous serum skin test (ASST) as marker HRA, were randomized 4 mg kg−1 daily (Sandimmun®, n = 20) or placebo (n 10) for weeks. Non-responders offered open-label All followed 20 weeks until relapse; all...

The major histocompatibility complex (MHC) acts as a marker for self during T‐cell ontogeny and is associated with the pathogenesis of many autoimmune diseases. Recent investigations have shown about 30% patients chronic idiopathic urticaria (CIU) IgG autoantibodies against high‐affinity IgE receptor, FcεRI, or IgE. A link between MHC class II alleles CIU has not been reported previously. DNA was extracted from blood 100 Caucasian CIU, type determined using polymerase chain reaction...

Background Chronic urticaria (CU) is an autoimmune process in some patients. An association between CU and thyroid disease has also previously been proposed. Our group identified functionally significant histamine‐releasing autoantibodies one subset of patients (subset 1), predicted by positive autologous intradermal serum tests histamine release from donor basophil leucocytes vitro. Sera a second 2), all whom had tests, failed to basophils. A final 3) no identifiable skin reactivity...

Acidic lipid extracts of scale from the lesions skin disease, psoriasis, were purified by straight phase high performance liquid chromatography (h.p.l.c). Assay fractions an agarose microdroplet chemokinesis method showed presence biologically active material that co‐eluted with standard leukotriene B 4 (LTB ). LTB ‐like chemokinetic activity was also detected in collected on reversed h.p.l.c. psoriatic initially No after similar purification obtained abrasion large areas normal skin. The...

Three patients were studied in whom brief contact of the skin with water at any temperature evoked intense itching without visible changes skin. The otherwise apparently healthy, and this chronic disabling disorder tended to attract a "psychogenic" label. Pharmacological studies showed that condition was associated local release acetyl choline skin, mast-cell degranulation, raised blood histamine concentrations. It responded well antihistamines two three patients. Aquagenic pruritus is...

The average annual intake of specific nutrients, foods, food groups, and proxies for nutrient bioavailability 87 Mexican preschoolers 110 schoolchildren were compared with their anthropometry. Median intakes energy, protein, thiamine, iron adequate; calcium zinc low; other nutrients very inadequate. Anaemia low serum retinol common. Intake individual failed to predict size. Correlation matrices, median traces, principal-components analysis illustrated a dietary continuum ranging from high...

We report the investigation and treatment of a 28-year-old woman with rare condition non-familial vibratory angiodema. Lesions were reproduced using vibrator set at pre-determined frequencies amplitudes, applied for fixed time period. There was no indication production tolerance in patient repeated vibration, but terfenadine produced good therapeutic response. evidence mast cell degranulation ultrastructural level. The also had mild delayed pressure urticaria dermographism, thus...

Twenty‐seven biopsy specimens from 11 patients with pressure urticaria were studied. Sixteen of the spontaneous lesions, which five pairs early and late lesions. Some lesions showed neutrophilia eosinophilia in deep tissue, significant perivascular lymphocytosis eosinophilia. Eleven dermograph‐ometer‐induced superficial localized dermal tissue progressive tissue; vascular tissues occasionally involved. The level Cl‐esterase inhibitor was elevated eight nine cases We believe that may be...

A new variant of cholinergic urticaria is described. Four patients each had a similar persistent macular skin rash distributed maximally over the upper limbs and trunk. Though was persistent, individual macules were short duration hut continually appeared at adjacent sites. Exercise hot baths exacerbated pruritus provoked lesions in previously unaffected areas. Topically applied benzoyl scopolamine blocked appearance after challenge. Tests function normal, apart from an exaggerated pupillary...

Journal Article The role of chemo‐attractant lipoxygenase products in the pathogenesis psoriasis Get access R. D. CAMP, CAMP Institute Dermatology, Homerton Grove, London E9 6BX, U. K. Dr Camp, Search for other works by this author on: Oxford Academic Google Scholar A. I. MALLET, MALLET F. M. CUNNINGHAM, CUNNINGHAM E. WONG, WONG P. WOOLLARD, WOOLLARD DOWD, DOWD KOBZA BLACK, BLACK W. GREAVES British Volume 113, Issue s28, 1 July 1985, Pages 98–103,...

Journal Article Skin exudate levels of interleukin 6, i and other cytokines in mycosis fungoides Get access FRANCES LAWLOR, LAWLOR Institute Dermatology, St Thomas's Hospital, London Dr Frances Lawlor, Lambeth Palace Road, SE17EH, U.K. Search for works by this author on: Oxford Academic Google Scholar N.P. SMITH, SMITH Tumour Unit, John's Hospital Diseases the Skin, R.D.R. CAMP, CAMP K.B. BACON, BACON ANNE KOBZA BLACK, BLACK M.W. GREAVES, GREAVES A.J.H. GEARING National Biological Standards...

Journal Article Cholinergic dermographism Get access S.C. MAYOU, MAYOU St John's Hospital for Diseases of the Skin, Lisle Street, Leicester Square, London WC2H 7BJ Search other works by this author on: Oxford Academic Google Scholar A.KOBZA BLACK, BLACK Institute Dermatology, Homerton Grove, E9 6BX, U.K. Dr A.Kobza Black. R.A.J. EADY, EADY M.W. GREAVES British Volume 115, Issue 3, 1 September 1986, Pages 371–377, https://doi.org/10.1111/j.1365-2133.1986.tb05754.x Published: 01 1986 history...

The purpose of this study was to determine if students (n = 431) from two southern universities-one in the "buckle" Bible-belt, other a "border" state-have different drinking behaviors depending on their religiosity and spirituality. Approximately 95% indicated that they had at least one drink alcohol during lives, with almost 82% reporting used past 30 days. Binge among underage increased every year (approximately 43% 70%). Students buckle university higher degrees spirituality reported...