A5090894986- Genetic and Kidney Cyst Diseases
- Bioactive Compounds and Antitumor Agents
- Neuropeptides and Animal Physiology
- Advancements in Transdermal Drug Delivery
- Protein Kinase Regulation and GTPase Signaling
- Pain Mechanisms and Treatments
- Microtubule and mitosis dynamics
- Thermoregulation and physiological responses
- Endoplasmic Reticulum Stress and Disease
- Ion Channels and Receptors
- Dermatology and Skin Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Protist diversity and phylogeny
- Phytochemicals and Antioxidant Activities
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cellular transport and secretion
King's College London
2021-2024
Jazan University
2021-2024
British Heart Foundation
2022
Dysregulation of endothelial barrier integrity can lead to vascular leak and potentially fatal oedema. TNF-α controls permeability during inflammation requires the actin organizing Ezrin-Radixin-Moesin (ERM) proteins. We identified TRAF2 NCK-interacting kinase (TNIK) as a directly phosphorylating activating ERM, specifically at plasma membrane primary human cells. TNIK mediates TNF-α–dependent cellular stiffness paracellular gap formation in vitro is essential driving inflammatory oedema...
Oedema formation and polymorphonuclear leukocyte (neutrophil) accumulation are involved in both acute chronic inflammation. Calcitonin gene-related peptide (CGRP) is a sensory neuropeptide that released from stimulated nerves. CGRP potent vasodilator neuropeptide, especially when administered to the cutaneous microvasculature, with long duration of action. Here, we have investigated ability amounts modulate oedema neutrophil induced microvasculature mouse. To learn more about mechanism...
Recently, we found that the deletion of TRPC5 leads to increased inflammation and pain-related behaviour in two animal models arthritis. (-)-Englerin A (EA), an extract from East African plant Phyllanthus engleri has been identified as a TRPC4/5 agonist. Here, studied whether or not EA any anti-inflammatory analgesic properties via carrageenan model inflammation. We treatment CD1 mice inhibited thermal hyperalgesia mechanical allodynia dose-dependent manner. Furthermore, significantly...
Inflammatory edema formation and polymorphonuclear leukocyte (neutrophil) accumulation are common components of cutaneous vascular inflammation, their assessment is a powerful investigative drug development tool but typically requires independent cohorts animals to assess each. We have established the use mathematical formula estimate ellipsoidal-shaped volume edematous wheal or bleb after intradermal injections substances in mice pretreated intravenously with Evans blue dye (which binds...
Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main source(s): British Heart Foundation Introduction Cardiovascular inflammation is associated with endothelial cell (EC) damage, resulting in leukocyte trafficking and oedema formation. Inflammation disrupts EC junctions, increasing microvascular permeability, a positive-feedback loop inflammatory events. The phosphoinositide 3-kinase pathway stimulates this response study examined the actions BYL-719, PI3K-α...