A5100774137- Spectroscopy Techniques in Biomedical and Chemical Research
- Epigenetics and DNA Methylation
- Spectroscopy and Chemometric Analyses
- Computational Drug Discovery Methods
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Machine Learning in Materials Science
- Optical Imaging and Spectroscopy Techniques
- Protein Interaction Studies and Fluorescence Analysis
- Antibiotics Pharmacokinetics and Efficacy
- Photoacoustic and Ultrasonic Imaging
- Antibiotic Use and Resistance
- Reproductive System and Pregnancy
- Optical Coherence Tomography Applications
- Antibiotic Resistance in Bacteria
- Advanced Fluorescence Microscopy Techniques
- Cholinesterase and Neurodegenerative Diseases
- Genetics, Bioinformatics, and Biomedical Research
- Respiratory and Cough-Related Research
- Respiratory viral infections research
- Gene expression and cancer classification
- Metabolomics and Mass Spectrometry Studies
- Ferroptosis and cancer prognosis
- Pediatric health and respiratory diseases
- Bioinformatics and Genomic Networks
Jiangnan University
2023
Wuxi Fourth People's Hospital
2023
Xidian University
2020-2023
Wuhan Polytechnic University
2022
Abstract We present a multimodal multi-species multi-omics multi-tissue transformer for aging research and drug discovery capable of performing multiple tasks such as age prediction across species, target discovery, tissue, sex, disease sample classification, sensitivity prediction, replication omics response biological phenotypic to compound treatment. This model combines textual, tabular, knowledge graph-derived representations experiments provide insights into molecular-level processes....
Mesoscale volumetric imaging is of great importance for the study bio-organisms. Among others, optical projection tomography provides unprecedented structural details specimens, but it requires fluorescence label chemical targeting. Raman spectroscopic able to identify components in a label-free manner lacks microstructure. Here, we present dual-modality optical-Raman (ORPT) technology, which enables three-dimensional microstructures and millimeter-sized samples with micron-level spatial...
Scattering can seriously affect the highly sensitive detection and quantitative analysis of chemical substances in scattering media becomes a significant challenge for vivo application Raman spectroscopy. In this study, we demonstrated proof concept using self-reconstructing Bessel beam spectroscopic sensing chemicals handmade biological tissue slices. The homebuilt spectroscopy (BRS) was capable accurately detecting spectra buried media, had superiority analysis. feasibility developed...
Cardiotoxicity, particularly drug-induced arrhythmias, poses a significant challenge in drug development, highlighting the importance of early-stage prediction human ether-a-go-go-related gene (hERG) toxicity. hERG encodes pore-forming subunit cardiac potassium channel. Traditional methods are both costly and time-intensive, necessitating development computational approaches. In this study, we introduce AttenhERG, novel graph neural network framework designed to predict channel blockers...
The AlphaFold computer program predicted protein structures for the whole human genome, which has been considered as a remarkable breakthrough both in artificial intelligence (AI) application and structural biology. Despite varying confidence level, these still could significantly contribute to structure-based drug design of novel targets, especially ones with no or limited information. In this work, we successfully applied our end-to-end AI-powered discovery engines constituted...
Disturbances in circadian rhythms are known to affect immune functions. However, the long-term impact of abnormal on immune-related functions spleen poorly understood. Hence, we aimed investigate Per1/Per2 double-knockout (DKO) and wild-type (WT) mice aged 4, 9, 14 months. Compared WT mice, DKO had smaller white pulp (WP) lymphocyte germinal area, as well fewer cells with age-these differences were especially clear. The mortality, malondialdehyde (MDA) levels, reactive oxygen species (ROS)...
We retrospectively analysed related clinical data to determine the influencing factors better prevent and treat children's respiratory tract infection.The study participants were children with infection who had sputum cultured in our hospital between 2014 2021. Sputum samples extracted using negative suction pressure sent microbiological laboratory for testing. The testing results analysed.A total of 4610 collected, 508 positive detected. rate pathogenic bacteria was 11.02%. Escherichia coli...
Volumetric imaging enables rapid, quantitative and global measurements of cells, tissues or organisms to obtain their biomolecular information has become a powerful tool for studying cellular metabolism, brain function developmental biology. Optical projection tomography (OPT) plays an important role in whole-body organs, embryos because it three-dimensional (3D) with high spatial temporal resolution samples at the millimeter level. However, OPT technique relies on fluorescent labels...
To meet the diversity needs of diagnosis, treatment or prevention diseases, different pharmaceutical dosage forms are designed and manufactured. The main role each form is drug carrier. However, changing might have some other effects in clinical usages. For example, capsule tablets absorbed by intestine stomach respectively, solutions patches can act directly on surface skin etc. quantity quality analysis a key issue control. Therefore, it meaningful research developing facility method to...
<p>Supplementary figures and tables.</p>
<p>Supplementary figures and tables.</p>
Traditional drug detection technique is highly accurate but time consuming and labor intensive. Raman spectroscopy (RS) a fast non-destructive that provides detailed information on chemical composition, phase morphology, crystallinity molecular interaction of the sample. The current spectrometer mainly based use Gaussian light, providing with good signal to noise ratio for thin or transparent However, owing scattering effect, beam will become diffuse in medium. This makes it not conducive...
Objective This paper aims to assess the efficacy of tigecycline in treatment several different infections from a pharmacokinetic/pharmacodynamic (PK/PD) perspective. Materials and methods The minimum inhibitory concentration (MIC) test strip was used determine MICs clinical isolates tigecycline. A 5,000-subjects simulation performed by Crystal Ball software calculate probability achieving required PK/PD exposure. Results use standard dosing is predicted have good outcome for patients...