A5024939595- Human Health and Disease
- Healthcare Systems and Public Health
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Forensic and Genetic Research
- Forensic Anthropology and Bioarchaeology Studies
- Rheumatoid Arthritis Research and Therapies
- Biomarkers in Disease Mechanisms
- Neurological Disorders and Treatments
- Thyroid Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- S100 Proteins and Annexins
- Renin-Angiotensin System Studies
- Yersinia bacterium, plague, ectoparasites research
- Reproductive System and Pregnancy
- Nutrition, Genetics, and Disease
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Gynecological conditions and treatments
- Genetics and Physical Performance
- Wound Healing and Treatments
- Adipose Tissue and Metabolism
- Systemic Lupus Erythematosus Research
- Digestive system and related health
- Glutathione Transferases and Polymorphisms
- Cardiac, Anesthesia and Surgical Outcomes
Kazan Federal University
2014-2024
Lomonosov Moscow State University
2018-2023
Central Research Institute of Epidemiology
2023
Institute of Physico-Technical Problems of the North named VP Larionov
2022
Siberian Branch of the Russian Academy of Sciences
2022
Peoples' Friendship University of Russia
2013-2019
Russian New University
2019
Samara State Medical University
2016-2019
Ministry of Health of the Russian Federation
2019
Irkutsk State University
2018
The clinical and immunological spectrum of acute post-active COVID-19 syndrome overlaps with criteria used to characterize autoimmune diseases such as rheumatoid arthritis (RA) systemic lupus erythematosus (SLE). Indeed, following SARS-Cov2 infection, the innate immune response is altered an initial delayed production interferon type I (IFN-I), while NF-kappa B inflammasome pathways are activated. In lung digestive tissues, alternative extrafollicular against takes place with, consequently,...
To investigate diversity of mitochondrial gene pool Tatars inhabiting the territory middle Volga River basin, 197 individuals from two populations representing Kazan and Mishars were subjected for analysis DNA (mtDNA) control region variation. In addition, 73 genomes Mishar population sequenced completely. It was found that consists parts, but western Eurasian component prevails considerably (84% on average) over eastern Asian one (16%). Eastern mtDNAs detected in belonged to a heterogeneous...
Exercise-induced oxidative stress is a state that primarily occurs in athletes involved high-intensity sports when pro-oxidants overwhelm the antioxidant defense system to oxidize proteins, lipids, and nucleic acids. During exercise, linked muscle metabolism damage, because exercise increases free radical production. The T allele of Ala16Val (rs4880 C/T) polymorphism mitochondrial superoxide dismutase 2 (SOD2) gene has been reported reduce SOD2 efficiency against stress. In present study we...
The aim of this research was to assess lipid peroxidation (LPO) and antioxidative defense (AOD) changes in adolescent boys with obesity using the integral index. Materials Methods:We examined 19 first degree (the study group).The control group included 23 healthy boys.The collection anamnestic data, physical examination, anthropometric data analysis (body weight (BW), height, waist circumference (WC), hip (HC), body mass index (BMI)).Laboratory an assessment blood levels total cholesterol,...
Abstract A major challenge presently is not only to identify the genetic polymorphisms increasing risk diseases, but also find out factors and mechanisms, which can counteract a genotype by developing resilient phenotype. The objective of this study was examine acquired innate vagal mechanisms that protect against physical challenges haemorrhages in 19 athletes 61 non-athletes. These include examining change heart rate variability (HF-HRV; an indicator vagus activity) response orthostatic...
Oral microbiome changes take place at the initiation of rheumatoid arthritis (RA); however, questions remain regarding oral pre-RA stages in individuals with clinically suspect arthralgia (CSA). Two cross-sectional cohorts were selected including 84 Tatarstan women (15 early-RA as compared to CSA ranging from = 0 [n 22], 1 19], 2 11], and ≥ 3 17]) 42 established RA (median: 5 years diagnosis [IQ: 2-11]). Amplicon sequence variants (ASVs) obtained samples (16S rRNA) analyzed for alpha beta...
Abstract Mutations in the MYH9 gene result macrothrombocytopenia often associated with hemorrhages. Here, we studied function and structure of platelets three family members a heterozygous mutation R1933X gene, characteristic closely related disorders known as May-Hegglin anomaly Sebastian syndrome. The examination included complete blood count, smear microscopy, platelet flow cytometry (expression P-selectin active integrin αIIbβ3 before after activation), kinetics platelet-driven...
A familial history of rheumatoid arthritis (RA) predisposes an individual to develop RA. This study aimed at investigating factors associated with this conversion from the Tatarstan cohort.A total 144 individuals, referred as pre-RA and risk for RA, were selected 2 years (range: 2-21 years) before RA compared non-converted 328 first-degree relatives (FDR) assessed after ≥2 follow-up, 355 healthy controls also (HC). Preclinical parameters socio-demographic/individual/HLA genetic analyzed when...
Genetic predisposition alongside with environmental factors play a major role in the pathogenesis of coronary heart disease, causing deregulation various biochemical processes leading to disease onset. Antioxidant system deregulation, marked mainly by lipid peroxidation products and number enzymes, is known be one risk for disease. A genetic defect might lead change enzyme activity inhibition antioxidant protection. However, pathogenic mechanisms different clinical courses are not studied...
Currently, the issues of recurrent course cardiovascular diseases are given great importance. Today, there is a search for more and new factors causes, including genetic ones, that contribute to increase in incidence circulatory system diseases. The study polymorphic variants hemostasis genes made it possible molecular mechanisms underlying causes complications. Polymorphism theSERPINE-1gene, encoding plasminogen activator inhibitor-1, associated with occurrence This literature review...
Predicting the outcome of in vitro fertilization is great importance when deciding on use this method. The purpose study was to determine echographic and morphological criteria for readiness endometrium implantation increase effectiveness IVF. case-control method used select examine 250 women, divided into 3 groups: group 1 (main group, IVF 1, n=87) included infertile women planning first time, 2 (comparison 2, n=83) - with unsuccessful previous attempts; (control n=80) a history...
The paper analyzes 3 clusters that differ in the growth rate of Covid-19 from point view socio-economic structure regions Russian Federation. In addition, database also contains clinical indicators characterizing morbidity regions, nosocomial infection, investment parameters and state transport system. Cluster analysis methods was carried out to identify relationship between characteristics regions. first cluster is more densely populated, assigned second are removed each other. Perhaps for...
Creating new biopesticides for protecting agricultural crops and developing their application methods, which are among the priority areas of agro-industrial complex, inextricably linked with continuous observation soil microbiocenosis, growing plants, changes in agro-climatic conditions a specific region. Plant endophytes potentially active bioagents creating microbiological preparations winter crops, as well produce during its storage period. In connection this, morphophysiological...
Реферат.Цель исследования -оценка уровня экспрессии генов, относящихся к классу скавенджер-рецепторов, при разных клинических формах атеросклероза.Материал и методы.Анализ генов скавенджер-рецепторов CD36, CD68, MARCO, MSR1, SCARB2 моноцитов макрофагов проводили у 150 человек: 1-я группа -больные с мультифокальным атеросклерозом (n=48); 2-я ишемической болезнью сердца, осложненной острым коронарным синдромом (n=46); 3-ю группу составили пациенты без признаков атеросклеротического поражения...