A5032811880- Climate variability and models
- Hydrology and Drought Analysis
- Geology and Paleoclimatology Research
- Tree-ring climate responses
- Monoclonal and Polyclonal Antibodies Research
- Hydrology and Watershed Management Studies
- Water resources management and optimization
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- HER2/EGFR in Cancer Research
- Angiogenesis and VEGF in Cancer
- Caveolin-1 and cellular processes
- Meteorological Phenomena and Simulations
- Oceanographic and Atmospheric Processes
- Lung Cancer Treatments and Mutations
- Peroxisome Proliferator-Activated Receptors
- Immune cells in cancer
- Water-Energy-Food Nexus Studies
- Climate change impacts on agriculture
- Tropical and Extratropical Cyclones Research
- Cancer, Hypoxia, and Metabolism
- Climate change and permafrost
- Geological and Geophysical Studies
- Cryospheric studies and observations
- Cancer Treatment and Pharmacology
Monash University
2019-2024
University of Wollongong
2022-2024
The University of Melbourne
2015-2024
ARC Centre of Excellence for Climate System Science
2016-2024
Johnson & Johnson (United States)
2024
Ecosystem Sciences
2024
Janssen (United States)
2020-2024
Australian Research Council
2017-2022
Australian Regenerative Medicine Institute
2022
Aston University
2021
Abstract The 2019/20 Black Summer bushfire disaster in southeast Australia was unprecedented: the extensive area of forest burnt, radiative power fires, and extraordinary number fires that developed into extreme pyroconvective events were all unmatched historical record. Australia’s hottest driest year on record, 2019, characterised by exceptionally dry fuel loads primed landscape to burn when exposed dangerous fire weather ignition. combination climate variability long-term trends generated...
Abstract Reproducible climate reconstructions of the Common Era (1 CE to present) are key placing industrial-era warming into context natural climatic variability. Here we present a community-sourced database temperature-sensitive proxy records from PAGES2k initiative. The gathers 692 648 locations, including all continental regions and major ocean basins. trees, ice, sediment, corals, speleothems, documentary evidence, other archives. They range in length 50 2000 years, with median 547...
Substituted N-(4-(2-aminopyridin-4-yloxy)-3-fluoro-phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamides were identified as potent and selective Met kinase inhibitors. Substitution of the pyridine 3-position gave improved enzyme potency, while substitution pyridone 4-position led to aqueous solubility selectivity. Analogue 10 demonstrated complete tumor stasis in a Met-dependent GTL-16 human gastric carcinoma xenograft model following oral administration. Because its excellent...
Emerging literature suggests that metabolic pathways play an important role in the maintenance and progression of human cancers. In particular, recent studies have implicated lipid biosynthesis desaturation as a requirement for tumor cell survival. reported here, we aimed to understand whether cells require activity either isoform stearoyl-CoA-desaturase (SCD1 or SCD5) Inhibition SCD1 by siRNA small molecule antagonist results strong induction apoptosis growth inhibition, when are cultured...
Climate variability in the tropical Pacific affects global climate on a wide range of time scales. On interannual scales, is home to El Niño–Southern Oscillation (ENSO). Decadal variations and changes Pacific, referred here collectively as decadal (TPDV), also profoundly affect system. Here, we use TPDV refer any form or change that occurs atmosphere, ocean, over land within Pacific. “Decadal,” which broad sense encompass multiyear through multidecadal includes about mean state externally...
A multi-scenario, multi-model ensemble of simulations from regional climate models is outlined to provide the core data source for a set projections and change service. subset realisations CMIP6 Global Climate Models (GCMs) are selected downscaling by Regional (RCMs) under 'sparse matrix' framework using CORDEX guidelines Shared Socio-economic Pathways that feature low emissions (SSP1-2.6) high (SSP3-7.0). The excludes poor performing models, with performance assessed climatology over large...
Mass coral bleaching on the Great Barrier Reef (GBR) in Australia between 2016 and 2024 was driven by high sea surface temperatures (SST)
Abstract Small molecule inhibitors targeting mutant EGFR are standard of care in non–small cell lung cancer (NSCLC), but acquired resistance invariably develops through mutations or activation compensatory pathways such as cMet. Amivantamab (JNJ-61186372) is an anti-EGFR and anti-cMet bispecific low fucose antibody with enhanced Fc function designed to treat tumors driven by activated and/or cMet signaling. Potent vivo antitumor efficacy observed upon amivantamab treatment human tumor...
Abstract. In drought-prone Australia, multi-year droughts have detrimental impacts on both the natural environment and human societies. For responsible water management, we need a thorough understanding of full range variability in how this might change warming world. But research into long-term frequency, persistence, severity Australian is limited. This partly due to length observational record, which short relative timescales hydroclimatic hence may not capture possible variability. Using...
Conformationally constrained 2-pyridone analogue 2 is a potent Met kinase inhibitor with an IC50 value of 1.8 nM. Further SAR the based inhibitors led to 4-pyridone and pyridine N-oxide such as 3 4. The X-ray crystallographic data bound ATP binding site protein provided insight into modes these inhibitors, this series analogues was rationalized. Many showed antiproliferative activities against dependent GTL-16 gastric carcinoma cell line. Compound also inhibited Flt-3 VEGFR-2 kinases values...
Abstract. Australian seasonal rainfall is strongly affected by large-scale ocean–atmosphere climate influences. In this study, we exploit the links between these precipitation influences, regional variations, and palaeoclimate proxies in region to reconstruct four eight centuries into past. We use an extensive network of records from Southern Hemisphere cool (April–September) warm (October–March) season natural resource management (NRM) regions spanning continent. Our bi-seasonal...
Accelerated warming and hiatus periods in the long-term rise of Global Mean Surface Temperature (GMST) have, recent decades, been associated with Interdecadal Pacific Oscillation (IPO). Critically, decadal climate prediction relies on skill state-of-the-art models to reliably represent these low-frequency variations. We undertake a systematic evaluation simulation IPO suite Coupled Model Intercomparison Project 5 (CMIP5) models. track pre-industrial (control) all-forcings (historical)...
Abstract Global temperature is rapidly approaching the 1.5°C Paris target. In absence of external cooling influences, such as volcanic eruptions, projections are centered on a breaching target, relative to 1850–1900, before 2029. The phase Interdecadal Pacific Oscillation (IPO) will regulate rate at which mean approaches level. A transition positive IPO would lead projected exceedance target around 2026. If Ocean remains in its negative decadal phase, be reached 5 years later, 2031. Given...
Abstract Tumor angiogenesis is a complex and tightly regulated network mediated by various proangiogenic factors. The fibroblast growth factor (FGF) vascular endothelial (VEGF) family of factors, associated tyrosine kinase receptors have major influence in tumor dissemination may work synergistically to promote angiogenesis. Brivanib alaninate the orally active prodrug brivanib, selective dual inhibitor FGF VEGF signaling. Here, we show that brivanib demonstrates antitumor activity broad...
A hierarchical framework for incorporating modes of climate variability into stochastic simulations hydrological data is developed, termed the climate‐informed multi‐time scale (CIMSS) framework. case study on two catchments in eastern Australia illustrates this To develop an identifiable model characterizing long‐term first level hierarchy, paleoclimate proxies, and instrumental indices describing Interdecadal Pacific Oscillation (IPO) Decadal (PDO) are analyzed. new paleo IPO‐PDO time...