A5100697784- Mesenchymal stem cell research
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Cleft Lip and Palate Research
- Dental Trauma and Treatments
- Oral microbiology and periodontitis research
- Cell Adhesion Molecules Research
- Bioactive natural compounds
- Receptor Mechanisms and Signaling
- Extracellular vesicles in disease
- Histone Deacetylase Inhibitors Research
- IL-33, ST2, and ILC Pathways
- Wound Healing and Treatments
- Antimicrobial Peptides and Activities
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- Protein Degradation and Inhibitors
- Periodontal Regeneration and Treatments
- Natural product bioactivities and synthesis
- dental development and anomalies
- Inflammasome and immune disorders
- MXene and MAX Phase Materials
- Connective tissue disorders research
First Affiliated Hospital of Guangzhou Medical University
2014-2019
Guangzhou Medical University
2014-2019
Harbin Medical University
2017
Atherosclerosis (AS) is an inflammatory disease linked to endothelial dysfunction. Melatonin reported possess substantial anti-inflammatory properties, which has proven be effective in AS. Emerging literature suggests that pyroptosis plays a critical role during AS progression. However, whether contributes dysfunction and the underlying molecular mechanisms remained unexploited. This study was designed investigate antipyroptotic effects of melatonin atherosclerotic endothelium elucidate...
Mesenchymal stem cell transplantation (MSCT) promotes cutaneous wound healing. Numerous studies have shown that the therapeutic effects of MSCT appear to be mediated by paracrine signaling. However, cell-cell interaction during between MSCs and macrophages in region healing is still unknown. In this study, early depletion delayed repair with MSC injection, which suggested MSC-mediated required macrophages. Moreover, we demonstrated systemically infused bone marrow (BMMSCs) jaw (JMMSCs) could...
Periodontal ligament stem cells (PDLSCs) from periodontitis patients showed defective osteogenic differentiation. However, the mechanism of impaired differentiation PDLSCs in inflammatory microenvironments is still unclear. In this study, we found that inflammation microenvironment resulted downregulation histone acetyltransferase GCN5 expression and lack caused decreased PDLSCs. Previous study activated Wnt/β-cateinin pathway Here knockdown DKK1, an inhibitor pathway, thus Wnt/β-catenin...
Inflammatory microenvironment causes the change of epigenetic modification in periodontal ligament stem cells derived from periodontitis tissues (P-PDLSCs), which results defective osteogenic differentiation compared to healthy tissues. It's urgent explore therapeutic strategies aimed at targets associated with regenerative ability PDLSCs. Osthole, a small-molecule compound extracted Chinese herbs, has been documented promote osteogenesis and cell sheets formation However, whether osthole...
The longstanding goal of periodontal therapy is to regenerate tissues. Although platelet-rich plasma (PRP) has been gaining increasing popularity for use in the orofacial region, whether PRP useful regeneration still unknown. purpose this study was determine a mixture ligament stem cell (PDLSC) sheets and promoted bone regeneration, one most important measurement indices tissue regenerative capability vitro vivo. In study, we evaluated effects different doses on differentiation human PDLSCs....
Clear-cell renal cell carcinoma (ccRCC) is an aggressive and malignant kidney cancer which has the worst prognosis. Although microRNAs (miRNAs) have recently been identified as a novel class of regulators in oncogenesis metastasis, there are few studies on their participation ccRCC. In present study, we observed that miR-367 expression was increased both human ccRCC tissues lines. Cell proliferation evaluated by MTT assay 5-Ethynyl-2'-deoxyuridine (EdU) kit, indicated inhibition could...
This study aims to investigate the mechanism of K (lysine) acetyltransferase 2A (KAT2A) regulation and control on osteogenic differentiation periodontal ligament stem cells (PDLSCs).The expression levels KAT2A in PDLSCs were compared from each generation normal (H-PDLSCs) periodontitis tissues (P-PDLSCs). The influences gene interference also detected. In addition, canonical Wnt pathway ligands upstream down-stream relationships between determined.The decreased inflammatory tissue was with...
Abstract Cancer is a complex disease involving the interplay of several types malignant and nonmalignant cells. The growth tumors surrounding stromal cells can be modeled as an ecosystem, where populations cancerous healthy interact compete for resources. In this work, we have explored application game theoretic models cancer to design novel anticancer therapies. Notably, theoretic-model tumor-stromal interactions capture impact between cell used investigate frequency-dependent parameters...