A5058052126- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Venous Thromboembolism Diagnosis and Management
- Neurological and metabolic disorders
- Diet and metabolism studies
- Nutritional Studies and Diet
- Neurological Disorders and Treatments
- Cardiovascular Health and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Lipids, and Metabolism
- Alcohol Consumption and Health Effects
- Gut microbiota and health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nutrition and Health in Aging
- Heart rate and cardiovascular health
- Intracranial Aneurysms: Treatment and Complications
- Stroke Rehabilitation and Recovery
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pharmacogenetics and Drug Metabolism
- Dialysis and Renal Disease Management
National Clinical Research Center for Digestive Diseases
2019-2025
Capital Medical University
2019-2025
Beijing Tian Tan Hospital
2019-2025
Beijing Advanced Sciences and Innovation Center
2022
Chinese Institute for Brain Research
2019-2020
Background: Lp(a) (lipoprotein(a)) contributes to cardiovascular disease mainly through proatherogenic and proinflammatory effects. Here, we aimed evaluate whether a residual stroke risk of would remain when the LDL-C (low-density lipoprotein cholesterol) inflammatory levels are maintained low. Methods: This prospective cohort study included 9899 patients with ischemic or transient attack from Third China National Stroke Registry who had measurements plasma were followed up for 1 year....
Importance Evidence on the bleeding risk associated with low-density lipoprotein cholesterol (LDL-C) levels in patients receiving dual antiplatelet therapy (DAPT) remains sparse. Objective To investigate association of LDL-C minor ischemic stroke (MIS) or high-risk transient attack (HRTIA) DAPT. Design, Setting, and Participants This cohort study was an analysis pooled data from 2 randomized, double-blind, placebo-controlled clinical trials China MIS HRTIA who were DAPT: CHANCE (Clopidogrel...
Background: Interleukin-6 (IL-6) plays an important role in the pathophysiology of atherosclerosis. This study aimed to determine whether IL-6 is a crucial biomarker associated with Multiple Acute Infarctions (MAIs), which indicate stroke mechanism artery-- to-artery embolism high risk recurrence symptomatic Intracranial Atherosclerotic Disease (sICAD). We tested association between circulating levels and presence MAIs prospective population-based registry. Methods: included 1,919 patients...
Background Trimethylamine N‐oxide (TMAO) contributes to cardiovascular disease through its prothrombotic, proatherothrombotic, and proinflammatory effects. We aimed evaluate whether residual risk of recurrent stroke TMAO precursor choline remain among patients who received dual‐antiplatelet therapy intensive lipid‐lowering with a low inflammation level (high‐sensitivity C‐reactive protein <2 mg/L on admission). Methods Results Patients ischemic or transient attack were enrolled from the...
Background Trimethyllysine, a trimethylamine N‐oxide precursor, has been identified as an independent cardiovascular risk factor in acute coronary syndrome. However, limited data are available to examine the role of trimethyllysine population with stroke. We aimed relationship between plasma levels and stroke outcomes patients presenting ischemic or transient attack. Methods Results Data 10 027 stroke/transient attack from CNSR‐III (Third China National Stroke Registry) 1‐year follow‐up for...
Background and Purpose— The role of dual-antiplatelet therapy with clopidogrel plus aspirin has been demonstrated to substantially decrease the risk recurrent stroke among patients minor transient ischemic attack. We aimed determine whether efficacy clopidogrel-aspirin / attack was influenced by stratification CYP2C19 genotype body mass index (BMI). Methods— loss-of-function allele (LoFA) carriers were defined as either LoFA *2 or *3. Low/normal weight overweight/obesity BMI <25 ≥25 kg/m...
Abstract High blood pressure (BP) is frequent in acute ischemic stroke (IS). However, the impact of BP change patterns during phase on clinical outcomes not conclusive. This study aims to investigate association between acute‐phase trajectories and IS patients with high admission BP. The cohort consisted 316 systolic (SBP) ≥160 mm Hg. SBP first 7 days after onset were characterized using a random effects model. classified into three groups based trajectory curve parameters: sustained (T1),...
Background High blood pressure variability (BPV) is a novel risk factor for cardiovascular disease. However, the heterogeneity of systolic (SBPV) and diastolic (DBPV) different vascular events remains unclear. This study aims to investigate whether SBPV or DBPV has contribution in patients with acute ischaemic stroke (IS) transient attack (TIA). Methods Data from BOSS (blood clinical outcome TIA IS) were examined at 3-month 1-year follow-up. BPV was defined as SD coefficient variation (CV)...
Background: The mechanism of obesity paradox in stroke is not clear. This study aimed to investigate whether uric acid (UA) contributes obesity-stroke outcome paradox. Material and Methods: cohort consisted 1,984 IS patients recruited the ACROSS-China study. Serum UA BMI were measured at admission. Low high groups defined by threshold 24, low age- sex-specific median. Poor outcomes as modified Rankin scale score ≥3 1 year after onset. Results: was significantly positively correlated with...
This study aimed to demonstrate the impact of cumulative burden cardiovascular risk factors (CVRFs) on events (CVEs). A total 34 959 participants were enrolled who participated in four surveys during 2006-2013. Cumulative CVRF was calculated as number years (2006-2013) multiplied by values CVRFs including systolic blood pressure, fasting glucose (FBG), low-density lipoprotein cholesterol (LDL-C), and high-sensitive C-reactive protein (hs-CRP). The primary outcome defined CVE 2012-2017,...
Background: In the context of recently updated strategies pressure management, there is a paucity evidence on effect diastolic blood (DBP) level adverse events among stroke patients. This study aimed to examine low DBP (<60 mmHg) under different levels systolic (SBP) risk composite and recurrence patients with ischemic (IS) or transient attack (TIA). Material Methods: was conducted in 2,325 IS TIA. values were categorized into <60, 60-70, 70-80 (reference), 80-90, ≥90 mmHg main sample...
Abstract Purpose Resting metabolic rate (RMR) could represent health status. This study aims to examine the association of predicted RMR with 1‐year poor functional outcome and all‐cause mortality in patients ischemic stroke as a proxy profile. Methods A total 15,166 or transient attack (TIA) from Third China National Stroke Registry (CNSR‐III) were enrolled this study. The Harris–Benedict equation based on sex, age, weight, height was used predict RMR. primary endpoints defined ≥3 modified...
Abstract The heart rate (HR) trajectory is a dynamic metric that shows how HR changes over time. Previous studies have demonstrated elevated associated with stroke events. However, little research has been done on the influence of shifting throughout acute period clinical outcomes. This study aims to investigate effect trajectories functional outcomes in patients ischemic (AIS). A total 981 AIS were included study. latent mixture model was used assess trends first 7 days following disease...
Abstract Background Acute embolic stroke has a high risk of recurrence, including artery-to-artery embolic, cardioembolism, and undetermined source. Whether lipoprotein(a) contributes to recurrence in patients remains unknown. Methods This prospective cohort biomarker sub-study included 8,076 with ischemic or transient attack from the Third China National Stroke Registry who had measurements plasma Lp(a) magnetic resonance imaging sequences were followed up for 1 year. Cutoffs set at 50...
Background: This study aims to assess the associations of functional outcomes following acute ischaemic stroke (IS) with ambulatory pulse rate (PR) and characterize time-variant properties associations.Methods: The prospective cohort consisted 1831 patients who had blood pressure (BP) PR monitoring IS, neurologic status evaluated at discharge 3-month follow-up. disability was defined as modified Rankin Scale ≥3. Logistic regression generalized penalized models were used examine BP...
Abstract Background Both high-sensitive C-reactive protein (hsCRP) and CYP2C19 genotypes are independent predictors of clinical outcomes after ischemic stroke. We aim to evaluate the association loss-of-function alleles (LoFA) carrying status with effects dual/single antiplatelet therapy at different hsCRP levels using High-Risk Patients Acute Non-disabling Cerebrovascular Events (CHANCE) trial. Methods Subjects both major information (*2, *3, *17) measurements were enrolled from...