A5066593507- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Acute Ischemic Stroke Management
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Infective Endocarditis Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Dialysis and Renal Disease Management
- Viral Infections and Vectors
- Antimicrobial Resistance in Staphylococcus
- Sleep and Wakefulness Research
- Stroke Rehabilitation and Recovery
- Influenza Virus Research Studies
- Vector-Borne Animal Diseases
- Diverse Scientific Research Studies
- Restless Legs Syndrome Research
- Liver Disease and Transplantation
- Hepatitis C virus research
- vaccines and immunoinformatics approaches
- SARS-CoV-2 detection and testing
- Alzheimer's disease research and treatments
- IgG4-Related and Inflammatory Diseases
- Venous Thromboembolism Diagnosis and Management
National Clinical Research Center for Digestive Diseases
2016-2025
Chinese Institute for Brain Research
2016-2025
Beijing Tian Tan Hospital
2016-2025
Capital Medical University
2016-2025
People's Liberation Army No. 150 Hospital
2025
Nanjing Agricultural University
2025
Capital University
2025
Beijing Normal University
2024
Beijing Sport University
2020-2024
Pfizer (United States)
2014-2024
Background and Purpose: Edaravone dexborneol, comprised of 2 active ingredients, edaravone (+)-borneol, has been developed as a novel neuroprotective agent with synergistic effects antioxidant anti-inflammatory in animal models. The present clinical trial aimed at testing the dexborneol versus on 90-day functional outcome patients acute ischemic stroke (AIS). Methods: A multicenter, randomized, double-blind, comparative, phase III was conducted 48 hospitals China between May 2015 December...
The recent authorization of oral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antivirals, such as Paxlovid, has ushered in a new era the COVID-19 pandemic. emergence variants, well selective pressure imposed by antiviral drugs themselves, raises concern for potential escape mutations key drug binding motifs.
To facilitate the detection and management of potential clinical antiviral resistance, in vitro selection drug-resistant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) against virus M
Infection of pathogenic bacteria and the abuse antibiotics are main factors in worldwide health issues. A number nanomaterials have been fabricated to directly battle drug-resistant bacteria. However, few studies referred relation between common daily carbon nanoparticles (e.g., automobile exhaust cigarette smoke) antimicrobial activities. Herein, dots (CDs) extracted from smoke introduced, showing low vivo vitro toxicity. These CDs show broad-spectrum activities that originate destruction...
ABSTRACT New variants of SARS-CoV-2 with potential for enhanced transmission, replication, and immune evasion capabilities continue to emerge causing reduced vaccine efficacy and/or treatment failure. As January 2021, the WHO has defined five ‘variants concern’ (VOC): B.1.1.7 (Alpha, α), B.1.351 (Beta, β), P.1 (Gamma, γ), B.1.617.2 (Delta, δ), B.1.1.529 (Omicron, o). To provide a therapeutic option COVID-19 variants, Nirmatrelvir, antiviral component PAXLOVID™, an oral outpatient recently...
Protection conferred by pneumococcal polysaccharide conjugate vaccines (PCVs) is associated with PCV-induced antibodies against vaccine-covered serotypes that exhibit functional opsonophagocytic activity (OPA). Structural similarity between capsular polysaccharides of closely related may result in induction cross-reactive or without a cross-functional serotype not covered PCV, the former providing an additional protective clinical benefit. Serotypes 15B, 15A, and 15C, serogroup 15, are among...
Elucidating the temporal process of immune remodeling under immunosuppressive treatment after liver transplantation (LT) is critical for precise clinical management strategies. Here, we performed a single-cell multi-omics analysis peripheral blood mononuclear cells (PBMCs) collected from LT patients (with and without acute cellular rejection [ACR]) at 13 time points. Validation was in two independent cohorts with additional healthy controls. Our study revealed four-phase recovery delineated...
Vaccines and first-generation antiviral therapeutics have provided important protection against COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, there remains a need for additional therapeutic options that provide enhanced efficacy potential viral resistance. The SARS-CoV-2 papain-like protease (PL
In the field of monocular 3D detection, it is common practice to utilize scene geometric clues enhance detector's performance. However, many existing works adopt these explicitly such as estimating a depth map and back-projecting into space. This explicit methodology induces sparsity in representations due increased dimensionality from 2D 3D, leads substantial information loss, especially for distant occluded objects. To alleviate this issue, we propose MonoNeRD, novel detection framework...
Hyponatremia has been identified as a relevant factor for cognitive impairment but not investigated in patients receiving peritoneal dialysis (PD). This study the relationship between hyponatremia and functions PD patients.
The incidence of multidrug-resistant Enterococcus faecium hospital infections has been steadily increasing. With the goal discovering new vaccine antigens, we systematically fractionated and purified four distinct surface carbohydrates from E. endocarditis isolate Tx16, shown previously to be resistant phagocytosis in presence human serum. two most abundant polysaccharides consist novel branched heteroglycan repeating units that include signature sugars altruronic acid legionaminic acid,...
Herpes Zoster (HZ) is reported as the most prevalent viral infection in patients with systemic lupus erythematosus (SLE). The aim of present study was to investigate clinical features, complications, and potential risk factors HZ SLE from Southern China. A retrospective performed among admitted First Affiliated Hospital Sun Yet‑Sen University (Guangzhou, China) between 2009 2013. Demographic information, laboratory data, medications used were collected analyzed. total 48 instances 46...
Staphylococcus aureus capsular polysaccharides (CP) are important virulence factors under evaluation as vaccine antigens. Clinical S. isolates have the biosynthetic capability to express either CP5 or CP8 and an understanding of relationship between CP genotype/phenotype epidemiology is valuable. Using whole genome sequencing, clonal relatedness genotype were evaluated for disease-associated selected from Tigecycline Evaluation Surveillance Trial (T.E.S.T) represent different geographic...
Abstract Vaccines and first-generation antiviral therapeutics have provided important protection against coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2). However, there remains a need for additional therapeutic options that provide enhanced efficacy potential viral resistance. The SARS-CoV-2 papain-like protease (PL pro ) is one of two essential cysteine proteases involved in replication. While inhibitors the main (M demonstrated clinical...
Background The impact of long‐term renal function change on stroke outcomes remains unclear. This study used the CNSR‐III (Third China National Stroke Registry) cohort to determine whether changes in estimated glomerular filtration rate based creatinine and cystatin C (eGFR Cr+CysC ) during first year post were associated with 5‐year outcomes. Methods Results We included 4270 patients centrally tested serum at admission 1 evaluated follow‐up data. Patients stratified into quintiles 1‐year...
Background This study aimed to assess the clinical outcome among patients with minor stroke, both and without disabling neurologic deficits (DNDs). It sought investigate efficacy of antiplatelet therapy using clopidogrel–aspirin versus aspirin alone within framework CHANCE (Clopidogrel in High‐Risk Patients With Acute Nondisabling Cerebrovascular Events) trial. Methods Results We enrolled 3725 stroke from were divided into 2 groups: those DNDs without, based on presence or absence DND, as...