A5042290064- SARS-CoV-2 and COVID-19 Research
- Crystallization and Solubility Studies
- ATP Synthase and ATPases Research
- X-ray Diffraction in Crystallography
- HER2/EGFR in Cancer Research
- Molecular Sensors and Ion Detection
- Monoclonal and Polyclonal Antibodies Research
- Diverse Scientific Research Studies
- interferon and immune responses
- RNA Interference and Gene Delivery
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- Viral Infections and Immunology Research
- Cytokine Signaling Pathways and Interactions
- Synthesis and Catalytic Reactions
- Crystallography and molecular interactions
- Mitochondrial Function and Pathology
- Medicinal Plants and Neuroprotection
- T-cell and B-cell Immunology
- Mast cells and histamine
- Synthetic Organic Chemistry Methods
- Metal complexes synthesis and properties
- Photochemistry and Electron Transfer Studies
- Luminescence and Fluorescent Materials
- Porphyrin and Phthalocyanine Chemistry
AbbVie (United States)
2023
University of Pittsburgh
2010
Ohio University
2008
Fluorescent sensors for the detection of chemical explosives are in great demand. It is shown herein that fluorescence ZnL* (H2L = N,N'-phenylene-bis-(3,5-di-tert-butylsalicylideneimine)) quenched solution by nitroaromatics and 2,3-dimethyl-2,3-dinitrobutane (DMNB), signatures explosives. The relationship between structure ZnL explored, crystal structures three forms ZnL(base), (base ethanol, tetrahydrofuran, pyridine) reported, with base ethanol exhibiting a four-centered hydrogen bonding...
Vaccines and first-generation antiviral therapeutics have provided important protection against COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, there remains a need for additional therapeutic options that provide enhanced efficacy potential viral resistance. The SARS-CoV-2 papain-like protease (PL
Nitroaromatics and nitroalkanes quench the fluorescence of Zn(Salophen) (H2Salophen = N,N′-phenylene-bis-(3,5-di-tert-butylsalicylideneimine); ZnLR) complexes. A structurally related family ZnLR complexes (R OMe, di-tBu, tBu, Cl, NO2) were prepared, mechanisms quenching by nitroaromatics studied a combined kinetics spectroscopic approach. The fluorescent quantum yields for generally high (Φ ∼ 0.3) with sub-nanosecond lifetimes. was quenched nitroaromatic compounds mixture static dynamic...
Abstract Vaccines and first-generation antiviral therapeutics have provided important protection against coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2). However, there remains a need for additional therapeutic options that provide enhanced efficacy potential viral resistance. The SARS-CoV-2 papain-like protease (PL pro ) is one of two essential cysteine proteases involved in replication. While inhibitors the main (M demonstrated clinical...
Aldol replacement: Catalytic asymmetric ketene–aldehyde cycloadditions provide surrogates for traditional aldol additions in an enantioselective synthesis of apoptolidinone C, the aglycone potent apoptosis regulator apoptolidin C. Eight C's ten stereocenters derive directly from these catalytic acetate or propionate equivalents. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited typeset. They made...
Abstract A strategy for pandemic preparedness is the development of antivirals against a wide set viral targets with complementary mechanisms action. SARS-CoV-2 nsp3-mac1 macrodomain ADP-ribosylhydrolase activity, which counteracts host immune response. Targeting virus’ immunomodulatory functionality offers differentiated to inhibit compared approved therapeutics, target replication directly. Here we report fragment-based lead generation campaign guided by computational approaches. We...
Antibody-drug conjugates consist of potent small-molecule payloads linked to a targeting antibody. Payloads must possess viable functional group by which linker for conjugation can be attached. Linker-attachment options remain limited the connection via hydroxyl groups. A releasing based on 2-aminopyridine was developed enable stable attachment para-aminobenzyl carbamate (PABC) linkers C21-hydroxyl budesonide, glucocorticoid receptor agonist. Payload release involves cascade two...
Tyrosine kinase 2 (TYK2) is a nonreceptor tyrosine that belongs to the JAK family also comprising JAK1, JAK2, and JAK3. TYK2 an attractive target for various autoimmune diseases as it regulates signal transduction downstream of IL-23 IL-12 receptors. Selective inhibition offers differentiated clinical profile compared currently approved inhibitors. However, selectivity versus other members has been difficult achieve with small molecules inhibit catalytically active domain. Successful...
Gleichwertiger Ersatz: Katalytische asymmetrische Keten-Aldehyd-Cycloadditionen ersetzen klassische Aldoladditionen in einer enantioselektiven Synthese von Apoptolidinon C, dem Aglycon des potenten Apoptoseregulators Apoptolidin C. Acht der zehn Stereozentren C leiten sich direkt diesen katalytischen Acetat- oder Propionat-Aldoläquivalenten ab.
Antibody-drug conjugates consist of potent small molecule payloads linked to a targeting antibody. Payloads must possess viable functional group by which linker for conjugation can be attached. Linker-attachment options remain limited connection via hydroxyl groups. A releasing based on 2-aminopyridine was developed enable stable attachment para-aminobenzyl carbamate (PABC) linkers the C21-hydroxyl budesonide, glucocorticoid receptor agonist. Payload release involves cascade two...