A5100696696- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- Chemical synthesis and alkaloids
- Natural product bioactivities and synthesis
- Phytochemical compounds biological activities
- Sesquiterpenes and Asteraceae Studies
- Marine Sponges and Natural Products
- Phytochemistry and Biological Activities
- Plant Pathogens and Fungal Diseases
- Melanoma and MAPK Pathways
- Plant biochemistry and biosynthesis
- Steroid Chemistry and Biochemistry
- Synthesis and biological activity
- Chemokine receptors and signaling
- Cancer Treatment and Pharmacology
- Mycorrhizal Fungi and Plant Interactions
- Phytochemistry and Bioactivity Studies
- Alkaloids: synthesis and pharmacology
- Traditional and Medicinal Uses of Annonaceae
- Genomics and Phylogenetic Studies
- Phytochemistry and Bioactive Compounds
- Peptidase Inhibition and Analysis
- Medicinal plant effects and applications
- Algal biology and biofuel production
- Hormonal Regulation and Hypertension
Pfizer (United States)
2020-2024
Minzu University of China
2022-2024
Universität Ulm
2022-2024
Tsinghua University
2024
Beijing Tsinghua Chang Gung Hospital
2024
Third Affiliated Hospital of Zhengzhou University
2024
East China University of Technology
2023
Nanjing University of Chinese Medicine
2023
South Central Minzu University
2015-2022
South China University of Technology
2019-2022
Focal cortical dysplasia type II (FCDII) is a cerebral cortex malformation characterized by local structure disorganization, neuronal dysmorphology, and refractory epilepsy. Brain somatic mutations in several genes involved the PI3K/AKT/mTOR pathway are associated with FCDII, but they only found proportion of patients FCDII. The genetic causes underlying development FCDII other remain unclear. Here, we carried out whole exome sequencing targeted paired brain-blood DNA from identified brain...
Abstract Immune system molecules are expressed by neurons, yet their functions often unknown. We have identified IL-13 and its receptor IL-13Ra1 as neuronal, synaptic proteins in mouse, rat, human brains, whose engagement upregulates the phosphorylation of NMDAR AMPAR subunits and, turn, increases activity CREB-mediated transcription. demonstrate that increased is a hallmark traumatic brain injury (TBI) male mice well two distinct cohorts patients. also provide evidence upregulation protects...
To facilitate the detection and management of potential clinical antiviral resistance, in vitro selection drug-resistant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) against virus M
Abstract Acquired resistance to BRAFV600E inhibitors (BRAFi) in melanoma remains a common clinical obstacle, as is the case for any targeted drug therapy that can be developed given plastic nature of cancers. Although there has been significant focus on cancer cell-intrinsic properties BRAFi resistance, impact host immunity not explored. Here we provide preclinical evidence an autochthonous mouse model associated with restoration myeloid-derived suppressor cells (MDSC) tumor...
Matsutakone (1), a novel sterol with an unprecedented polycyclic ring system, together new norsteroid matsutoic acid (2) were isolated from the fruiting bodies of Tricholoma matsutake. Their structures and absolute configurations assigned by extensive spectroscopic analyses computational methods. Bioassay results showed that compounds 1 2 exhibited inhibitory activities against acetylcholinesterase (IC50 20.9 μM for 1).
Curtachalasins C–E (1–3), which have an unprecedent bridged 6/6/6/6 ring system, were identified from the endophytic fungus Xylaria cf. curta. Residual dipolar coupling analyses associating with density functional theory calculations utilized to determine relative configuration of noncrystallizable compound 2. The absolute configurations 1–3 determined by X-ray diffraction and electronic circular dichroism calculations. Remarkably, curtachalasin C (1) showed significant resistance reversal...
The histone deacetylase HDAC3 is a critical mediator of hepatic lipid metabolism, and liver-specific deletion leads to fatty liver. To elucidate the underlying mechanism, here we report method cross-linking followed by mass spectrometry define high-confidence interactome in vivo that includes canonical NCoR-HDAC3 complex as well Prospero-related homeobox 1 protein (PROX1). PROX1 co-localize extensively on mouse liver genome, are co-recruited hepatocyte nuclear factor 4α (HNF4α). HDAC3-PROX1...
Two unique cytochalasans, curtachalasins A (1) and B (2), were purified from the endophytic fungus Xylaria curta E10 harbored in plant Solanum tuberosum. Their structures determined by extensive spectroscopic methods, X-ray crystallographic analysis, electronic circular dichroism calculations. These two compounds feature an unprecedented pyrolidine/perhydroanthracene (5/6/6/6 tetracyclic skeleton) fused ring system.
A cytochalasan, xylarichalasin A, was obtained from the endophytic fungus Xylaria cf. curta harbored in Solanum tuberosum. Its structure elucidated by comprehensive spectroscopic methods including HRESIMS, 1D/2D NMR, and residual dipolar coupling analysis as well quantum chemistry calculations DFT GIAO 13C NMR ECD calculation. It has an unprecedented 6/7/5/6/6/6 fused polycyclic structure. In bioassay, showed cytotoxicity against human cancer cell lines with IC50 value ranging 6.3–17.3 μM.
Histone deacetylases are epigenetic regulators known to control gene transcription in various tissues. A member of this family, histone deacetylase 3 (HDAC3), has been shown regulate metabolic genes. Cell culture studies with HDAC-specific inhibitors and siRNA suggest that HDAC3 plays a role pancreatic β-cell function, but recent genetic study mice contradictory. Here we address the functional β-cells adult mice. An specific knockout was generated MIP-CreERT transgenic using Cre-loxP system....
This study features the isolation and identification of 12 lanostane-type triterpenoids, namely lepiotaprocerins A–L, 1–12, from fruiting bodies Poland-collected edible mushroom Macrolepiota procera. The structures absolute configurations new compounds were ambiguously established by extensive spectroscopic analyses, ECD calculation, single-crystal X-ray diffraction analyses. Structurally, A–F, 1–6, are distinguished presence a rare "1-en-1,11-epoxy" moiety which has not been previously...
Abstract An unprecedented inverse‐electron‐demand [4+2] cycloaddition reaction of in situ generated aza‐ o ‐quinone methides with 1,3,5‐triazinanes has been developed under mild conditions, providing an efficient and approach to synthesize tetrahydroquinazolines high yields (up 99%) excellent functional group tolerance. This protocol represents the first example 1,3,5‐triazinanes. magnified image
Pseudomonas syringae pv. actinidiae (Psa) is a Gram-negative bacterium causing the kiwifruit canker disease, resulting in serious economic losses to industry. This study investigated use of an endophytic fungus, Fusarium tricinctum, obtained from kiwi plant (Actinidia chinesis) as potential biocontrol strain against Psa. F. tricinctum showed inhibition rate 59.5% vitro Bioassay-guided isolation was conducted on cultural broth and seven new imidazole alkaloids, (±)-fusaritricine J ((±)-1)...
Aseptic loosening presents a formidable challenge within the realm of bone tissue engineering, playing pivotal role in occurrence joint replacement failures. The development therapeutic materials characterized by an optimal combination mechanical properties and biocompatibility is imperative to ensure enduring functionality implants over extended periods. In this context, study introduced injectable, temperature-sensitive irisin/oxidized starch/gelatin hybrid hydrogel (I-OG) system....
Conosilane A (1), a novel sesquiterpene with an unprecedented carbon skeleton, was isolated from the cultures of basidiomycete Conocybe siliginea. Its structure elucidated by extensive spectroscopic methods, and absolute configuration determined single crystal X-ray diffraction analysis. found to inhibit 11β-hydroxysteroid dehydrogenase significantly.
Visible light-induced difluoromethylation of <italic>N</italic>-arylacrylamides to afford difluoromethylated 2-oxindoles and quinoline-2,4-diones with difluoromethyl 2-pyridyl sulfones as radical precursors has been disclosed.
Eleven new cytochalasins were isolated from <italic>Xylaria</italic> cf. <italic>curta</italic>. Their selective immunosuppressive properties provide clues for drug development of immunosuppressants.
The unprecedented 1,3-dipolar cycloaddition of 1,3,5-triazinanes and aziridines has been described. With readily available starting material, this method offers efficient access to a wide range functionalized imidazolidine derivatives in moderate good yields (up 92%) under mild conditions. Preliminary mechanistic investigations show that the ring opened zwitterionic pathway product dominated over second-order nucleophilic substitution-like product. This protocol is very promising because...
Temperature variations of flue gas have an effect on carbon dioxide (CO2) emissions monitoring. This paper demonstrates accurate CO2 concentration measurement using tunable diode laser absorption spectroscopy (TDLAS) with temperature compensation methods. A distributed feedback at 1579 nm was chosen as the source for measurements. modeled made referring to concentrations 10–20% and temperatures 298–338 K in exhaust a power plant. Two methods based direct (DA) wavelength modulation (WMS) are...
Eighteen new nor-isopimarane diterpenes, xylarinorditerpenes A-R (1-18), along with two previously reported compounds, 14α,16-epoxy-18-norisopimar-7-en-4α-ol (19) and the labdane-type diterpene agatadiol (20), were isolated from cultures of fungicolous fungus Xylaria longipes HFG1018 wood-rotting basidiomycete Fomitopsis betulinus. The structure elucidation relative configuration assignments 1-18 accomplished by interpretation spectroscopic data through computational methods. absolute...