A5102801705- Immune Response and Inflammation
- HER2/EGFR in Cancer Research
- Immune Cell Function and Interaction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hypothalamic control of reproductive hormones
- Estrogen and related hormone effects
- Monoclonal and Polyclonal Antibodies Research
- Nicotinic Acetylcholine Receptors Study
- RNA modifications and cancer
- Glaucoma and retinal disorders
- Wnt/β-catenin signaling in development and cancer
- Growth Hormone and Insulin-like Growth Factors
- Ferroptosis and cancer prognosis
- Osteoarthritis Treatment and Mechanisms
- Glycosylation and Glycoproteins Research
- Bacteriophages and microbial interactions
- Muscle metabolism and nutrition
- Cancer Immunotherapy and Biomarkers
- Titanium Alloys Microstructure and Properties
- Retinoids in leukemia and cellular processes
- Cancer-related gene regulation
- Alcohol Consumption and Health Effects
- Orthopaedic implants and arthroplasty
- Heat shock proteins research
- Exercise and Physiological Responses
Shanghai Skin Disease Hospital
2024
Tongji University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2000-2023
Sichuan Agricultural University
2013-2021
Ziopharm Oncology (United States)
2009
National Institutes of Health
1994-1999
Health and Human Development (2HD) Research Network
1999
Eunice Kennedy Shriver National Institute of Child Health and Human Development
1996-1998
Lovelace Medical Center
1996
The Ohio State University
1993
Previously, we have shown that both T and B lymphocytes from chronically nicotine-treated (NT) animals exhibit tolerance to activation by Ags (ligation of Ag receptors), as indicated their decreased ability mobilize intracellular calcium and, at least in cells, arrest cells the G0/G1 phase cell cycle. Herein, demonstrate NT significantly lose up-regulate inositol trisphosphate synthesis response TCR ligation or nonspecific G proteins AIF-4. However, increases cAMP concentrations following...
Aseptic loosening presents a formidable challenge within the realm of bone tissue engineering, playing pivotal role in occurrence joint replacement failures. The development therapeutic materials characterized by an optimal combination mechanical properties and biocompatibility is imperative to ensure enduring functionality implants over extended periods. In this context, study introduced injectable, temperature-sensitive irisin/oxidized starch/gelatin hybrid hydrogel (I-OG) system....
The mouse thymidylate synthase promoter lacks a TATA box and initiates transcription at many sites across 90-nucleotide initiation window. We showed previously that wild-type activity is maintained with extends only 13 nucleotides upstream of the first start site. G/A-rich G/C-rich elements were identified in vicinity transcriptional goals present study to determine whether there are additional window why such broad region. Minigenes containing variety substitution, deletion, insertion...
Isolation and structural characterization of the rat corticotropin releasing factor receptor (CRFR) gene was performed to determine exon/intron organization coding region potential for splice variants. The CRFR contains 13 exons 12 introns, positions junctions are similar those other Class II G protein-coupled genes including parathyroid hormone glucagon receptors. promoter resides within 593 base pairs initiation codon major transcriptional start site at nucleotide −238. This domain does...
The functional importance of specific protein binding domains on transcription within the GC-rich 173-base pair promoter luteinizing hormone receptor gene was studied by mutagenesis and gel retardation analysis. Transcription dependent presence two Sp1 elements in domain transfected expressing mouse Leydig tumor cells (mLTC) nonexpressing Chinese hamster ovary cells. Mutation located downstream (M1 C-box) revealed tissue-specific regulation activity each domain. Also, studies indicated...
We are introducing a novel series of 2,4-diaminoquinazolines as β-catenin/Tcf4 inhibitors which were identified by ligand-based design. Here we elucidate the SAR this and explain how able to improve key molecular properties such solubility cLogP leading compound 9. Analogue 9 exhibited better biological activity improved physical pharmacological relative HTS hit 49. Furthermore, demonstrated good cell growth inhibition against several human colorectal cancer lines LoVo HT29. In addition,...
A novel human luteinizing hormone receptor (LHR) gene was isolated from a placental genomic library. This (Gene II) differs that previously lymphocyte library I) by several base changes in the 5′ flanking region and deletion of 6 nucleotides coding (+55 to +60). The sequence exon 1 II conforms ovarian LHR cDNA. Furthermore, primer extension reporter analyses indicate both Gene promoter mRNA transcriptional start sites are located within −176 bp TATA-less domain. Additional upstream (>−176...
Skin cutaneous melanoma (SKCM) is the deadliest dermatology tumor. Ongoing researches have confirmed that NOD-like receptors (NLRs) family are crucial in driving carcinogenesis. However, function of NLRs signaling pathway-related genes SKCM remains unclear.To establish and identify an NLRs-related prognostic signature to explore its predictive power for heterogeneous immune response patients.Establishment using by least absolute shrinkage selection operator-Cox regression analysis (LASSO-COX...
Heat shock protein 90 (HSP90), functions as a molecular chaperone in biosynthesis play an important role signal transduction, immune responses and embryogenesis. However, the function research of HSP90 invertebrates is limited. To further understand mechanism stress response, we have isolated fragment homologue from mud crab Scylla paramamosain through transcriptome sequencing mixture hepatopancreas hemocytes, The full-length cDNA harvested RACE technology it contains 73 bp 5’terminal UTR,...
Exon 1 of the human luteinizing hormone receptor (LHR) gene coding region exhibits at least two forms sequence heterogeneity between 37 and 60 bp, spanning junction signal peptide amino terminus mature protein. The LHR differs from 2 by insertion 6 bp in exon but is identical 5' flanking region. RFLP analysis haplotypes within a random population 63 individuals revealed allele frequencies 0. 0.63 for 2, respectively. 94% samples contained one allele, whereas only 68% allele. No gender...
As an activator of sirtuin 1, resveratrol has become extensively reviewed anti‑inflammatory and anti‑aging drug in recent years, it been widely studied for the treatment energy control endocrine diseases. The present study attempted to characterize role osteolysis induced by titanium (Ti) alloy particles Ti pins <em>in vitro</em> vivo</em>. <em>In vitro</em>, bone marrow mesenchymal stem cells were cultured with simulate osteolysis. Cell viability expression levels proteins associated...
Abstract Objective To study the function of RNA-binding protein Hfq in Bacillus subtilis cellulose decomposition. Results In medium with sodium carboxymethylcellulose (Na-CMC) as sole carbon source, knockout resulted a 38.0% ± 2.1% and 76.6% 7.1% decrease hydrolysis ability cellulase activity, respectively. The results real-time quantitative PCR revealed that several genes ( eglS , bglA bglC ) were significantly downregulated strain. isogenic ΔHfq complemented strain recovered ability,...