A5028699721- Cardiovascular Function and Risk Factors
- Metabolism and Genetic Disorders
- Metabolomics and Mass Spectrometry Studies
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Long-Term Effects of COVID-19
- Diet and metabolism studies
- Ion channel regulation and function
- Hernia repair and management
- ECG Monitoring and Analysis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Respiratory viral infections research
- Circular RNAs in diseases
- Health, Environment, Cognitive Aging
- Bioinformatics and Genomic Networks
- Appendicitis Diagnosis and Management
- Trypanosoma species research and implications
- Cutaneous Melanoma Detection and Management
- Connective tissue disorders research
- Influenza Virus Research Studies
- Intraperitoneal and Appendiceal Malignancies
- Protease and Inhibitor Mechanisms
- Renal Transplantation Outcomes and Treatments
- Genetic Associations and Epidemiology
- Frailty in Older Adults
Huazhong University of Science and Technology
2019-2024
Tongji Hospital
2019-2024
Union Hospital
2024
Zhejiang Chinese Medical University
2024
Abstract Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through production gut-derived metabolites. However, specific metabolites and their pathophysiological contribution cardiac hypertrophy or heart failure progression still remain unclear. N,N,N-trimethyl-5-aminovaleric acid (TMAVA), derived from trimethyllysine gut microbiota, was elevated with gradually increased risk mortality transplantation in a prospective...
Abstract Background Phenylacetylglutamine (PAGln)—a newly discovered microbial metabolite produced by phenylalanine metabolism—is reportedly associated with cardiovascular events via adrenergic receptors. Nonetheless, its association outcomes in heart failure (HF) patients remains unknown. Objectives This study aimed to prospectively investigate the prognostic value of PAGln for HF. Methods Plasma levels were quantified liquid chromatography‐tandem mass spectrometry. We first assessed...
Abstract Phenylacetylglutamine (PAGln) is an amino acid derivate that comes from the phenylalanine. There are increasing studies showing level of PAGln associated with risk different cardiovascular diseases. In this review, we discussed metabolic pathway production and quantitative measurement methods PAGln. We summarized epidemiological evidence to show role in diagnostic prognostic value several diseases, such as heart failure, coronary disease/atherosclerosis, cardiac arrhythmia. The...
Cardiac sialylation is involved in a variety of physiological processes the heart. Altered has been implicated heart failure (HF) mice. However, its role patients with HF unclear, and potential effect modulation cardiac worth exploring. We first assessed association between plasma N-acetylneuraminic acid levels incidence adverse cardiovascular events over median follow-up period 2 years. Next, immunoblot analysis lectin histochemistry were performed tissue to determine expression...
Background and Purpose The calcium antagonist amlodipine exerts important cardioprotective effects by modulating smooth muscle endothelial functions. However, the mechanisms underlying these are incompletely understood. Experimental Approach Western blotting was used to compare expression of key genes involved in vascular cell (VSMC) phenotype conversion. Recombinant adeno‐associated virus system regulate miRNA rats via tail vein. Bioinformatics predict transcriptional regulation miR‐21...
Abstract Aims The aim of this study was to investigate the effects Neuraminidase inhibitors (NI) on COVID-19 in a retrospective study. Methods and results included an overall patients (n = 3267) 1:1 propensity score-matched 972). levels plasma N-acetylneuraminic acid neuraminidase expression were further evaluated panel hospitalized 1-month post-infection recovered subjects. mortality rate 9.6% (313/3267) 9.2% (89/972) propensity-score matched patients. NI treatment lowered (5.7% vs. 10.3%)...
A critical challenge in genetic diagnostics is the assessment of variants associated with diseases, specifically that fall out canonical splice sites, by altering alternative splicing. Several computational methods have been developed to prioritize effect on splicing; however, performance evaluation these hampered lack large-scale benchmark datasets. In this study, we employed a splicing-region-specific strategy evaluate prediction based eight independent Under most conditions, found...
Carnitine has been associated with cardiac energy metabolism and heart failure, but the association between its precursors-trimethyllysine (TML) γ-butyrobetaine (GBB)-and failure preserved ejection fraction (HFpEF) remains unclear.To evaluate relationship TML-related metabolites HFpEF in an Asian population.The cross-sectional component of this study examined plasma HFpEF, while a prospective cohort design was applied to examine incident cardiovascular events HFpEF. Included were 1000...
Brugada syndrome (BrS) is an inheritable arrhythmia that can lead to sudden cardiac death in patients while the heart structure normal. However, genetic background of more than 65% BrS probands remains unclear.The purpose this study report variant spectrum a Chinese cohort with suspected and analyze their distinct clinical electrocardiographic features.Patients from Tongji Hospital between 2008 2021 were analyzed retrospectively.A total 79 included study. Patients type 1 electrocardiogram...
ABSTRACT Metabolic syndrome (MetS) remains a significant global public health concern. However, the relationship between MetS, its individual components and melanoma metastasis unexplored. We analysed clinical data of 258 Chinese patients who had not undergo systemic therapy. Binary logistic regression, adjusted for sex age, was employed to evaluate connection MetS metastasis. Of patients, 92 met criteria upon diagnosis. No direct association identified. specific namely low HDL‐cholesterol...
Introduction: Dilated cardiomyopathy (DCM) represents a diverse set of myocardial diseases characterized by notable genetic heterogeneity. Although over 50 genes have been associated with DCM, these collectively explain 35% idiopathic DCM cases. Variants in the FBN1 gene encoding fibrillin-1 are primarily linked to connective tissue disorders. Considering potential disorders impact tissue, this study probes into possible association between variants and DCM. Aim: The objective was...
Background: Genetic variants in Scavenger receptor Class B Type 1 (SCARB1) influencing high-density lipoprotein cholesterol (HDL-C) and coronary heart disease (CHD) risk were identified by recent genome-wide association studies. Further study of potential functional SCARB1 may provide new ideas the complicated relationship between HDL-C CHD. Methods: 2000 bp promoter region was re-sequenced 168 participants with extremely high plasma 400 control subjects. Putative alleles using...
Background: Brugada syndrome (BrS) is an inheritable arrhythmia that can lead to sudden cardiac death in patients while the heart structure normal. However, genetic background of more than 65% BrS probands remains unclear.Objectives: The purpose this study report variant spectrum a mainland Chinese cohort and analyze their distinct clinical electrocardiographic features.Methods: Patients suspected from Tongji Hospital between 2008 2021 were analyzed retrospectively.Results: A total 79...