A5102954130- Eicosanoids and Hypertension Pharmacology
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Caveolin-1 and cellular processes
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac pacing and defibrillation studies
- Sphingolipid Metabolism and Signaling
- Tea Polyphenols and Effects
- Pharmacogenetics and Drug Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Lipid metabolism and disorders
- Nutritional Studies and Diet
- Cardiovascular Effects of Exercise
- Phytochemicals and Antioxidant Activities
- Ion channel regulation and function
- Lysosomal Storage Disorders Research
- Cardiomyopathy and Myosin Studies
- Neurological disorders and treatments
- Ginkgo biloba and Cashew Applications
- Acute Kidney Injury Research
- MicroRNA in disease regulation
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
Beihang University
2025
SUNY Downstate Health Sciences University
2021-2023
State University of New York
2023
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active cis-epoxyeicosatrienoic acids, which have potent vasodilatory, antiinflammatory, antiapoptotic, and antidiabetes properties. Here, we showed the effects of cardiac-specific overexpression CYP epoxygenase 2J2 (CYP2J2) on diabetic cardiomyopathy insulin resistance in high-fat (HF) diet fed, low-dose streptozotocin-treated mice. Diabetic was induced by HF streptozotocin CYP2J2 transgenic Physiological...
Three-dimensional electroanatomic mapping systems have demonstrated a significant reduction in radiation exposure during radiofrequency catheter ablation procedures. We aimed to investigate the safety, feasibility and efficacy of completely zero-fluoroscopy approach for supraventricular tachycardia using Ensite NavX navigation system compared with conventional fluoroscopy approach.A multicenter prospective non-randomized registry study was performed seven centers from January 2013 February...
Cytochrome P-450 epoxygenase-derived epoxyeicosatrienoic acids (EETs) exert diverse biological activities, which include potent vasodilatory, anti-inflammatory, antiapoptotic, and antioxidatant effects, cardiovascular protection. Liver has abundant epoxygenase expression high levels of EET production; however, the roles epoxygenases in liver diseases remain to be elucidated. In this study, we investigated protection against high-fat diet-induced nonalcoholic fatty disease (NAFLD) mice with...
Cytochrome P-450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play important roles in regulating cardiovascular functions. The anti-inflammatory, antiapoptotic, proangiogenic, and antihypertensive properties of EETs suggest a beneficial role for diabetic nephropathy. Endogenous EET levels are maintained by balance between synthesis CYP hydrolysis epoxide hydrolases physiologically less active dihydroxyeicosatrienoic acids. Genetic disruption...
Background: Brugada syndrome (BrS) is a genetic cardiac arrhythmia disorder inherited in an autosomal dominant manner, characterized by ST-segment elevation the right precordial leads (V1-V3) on electrocardiograms (ECGs). This predominantly affects young individuals with structurally normal hearts and significantly increases risk of ventricular arrhythmias sudden death (SCD). The most common genotype found among BrS patients caused mutations SCN5A gene, which lead to loss function sodium...
Lentinan (LNT), a type of polysaccharide derived from Lentinus edodes, has manifested protective effects during liver injury and hepatocellular carcinoma, but little is known about its on nonalcoholic fatty disease (NAFLD). This study aimed to investigate whether LNT can affect the progression NAFLD associated mechanisms. C57BL/6J mice were fed normal chow diet or high-fat (HFD) with without (6 mg/kg/d). AML12 cells exposed 200 μM palmitate acid (PA) (5 μg/mL). After 21 wk diet,...
Objective The study aims to investigate the effect of cytochrome P450 2J2 (CYP2J2) overexpression on hyperlipidemia in mice and further explore its fatty acid oxidation vivo vitro. Methods effects mechanisms endothelial-specific CYP2J2 transgene (Tie2-CYP2J2-Tr) lipid metabolism were investigated high-fat diet (HFD) -treated mice. HepG2, LO2 cells, HUVECs exposed 0.4 mM free (FFA) for 24 h used as a model roles epoxyeicosatrienoic acids (EETs) β-oxidation Results Tie2-CYP2J2-Tr had...
Many patients with diabetes die from diabetic cardiomyopathy (DCM); however, effective strategies for the prevention or treatment of DCM have not yet been clarified. Leptin receptor-deficient (db/db) mice were treated either soluble epoxide hydrolase (sEH) inhibitor AUDA vehicle alone. A virus carrying Nrf2 shRNA was used to manipulate expression in db/db mice. Cardiac structures and functions analyzed using echocardiography hemodynamic examinations. Primary cardiomyocytes cultured under...