A5100381340- Viral Infections and Immunology Research
- Atrial Fibrillation Management and Outcomes
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- RNA and protein synthesis mechanisms
- Cardiac electrophysiology and arrhythmias
- RNA Research and Splicing
- Cardiac Arrhythmias and Treatments
- Respiratory viral infections research
- Cardiac Fibrosis and Remodeling
- Food Chemistry and Fat Analysis
- Bioinformatics and Genomic Networks
- Animal Virus Infections Studies
- Lipid metabolism and disorders
- Pesticide Residue Analysis and Safety
- Herpesvirus Infections and Treatments
- Animal Nutrition and Physiology
- Cardiac Structural Anomalies and Repair
- Proteins in Food Systems
- Meat and Animal Product Quality
- Cardiovascular Health and Disease Prevention
- Probiotics and Fermented Foods
- Cardiovascular Function and Risk Factors
Huazhong University of Science and Technology
2014-2025
Tongji Hospital
2014-2025
University of Iowa
2023-2024
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2021-2024
Wuhan University
2008-2024
Tianjin Hospital
2024
Tianjin University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Hunan Agricultural University
2022-2023
Shanghai Institute of Hypertension
2017-2022
Omecamtiv mecarbil (OM) is a selective cardiac myosin activator that increases myocardial function in healthy volunteers and patients with chronic heart failure.This study evaluated the pharmacokinetics, pharmacodynamics, tolerability, safety, efficacy of OM acute failure (AHF).Patients admitted for AHF left ventricular ejection fraction ≤40%, dyspnea, elevated plasma concentrations natriuretic peptides were randomized to receive double-blind, 48-h intravenous infusion placebo or 3...
The volume and composition of a thin layer liquid covering the airway surface defend lung from inhaled pathogens debris. Airway epithelia secrete Cl- into through cystic fibrosis transmembrane conductance regulator (CFTR) channels, thereby increasing liquid. discovery that pulmonary ionocytes contain high levels CFTR led us to predict drive secretion. However, we found opposite. Elevating ionocyte abundance increased absorption, whereas reducing In contrast other epithelial cells, contained...
The airway surface liquid (ASL) plays a crucial role in lung defense mechanisms, and its composition volume are regulated by the epithelium. cystic fibrosis transmembrane conductance regulator (CFTR) is abundantly expressed rare epithelial cell type called an ionocyte. Recently, we demonstrated that ionocytes can increase absorption through apical CFTR basolateral barttin/chloride channels, while secretory cells mediate secretion channels NKCC1 transporters. Th2-driven (IL-4/IL-13) diseases,...
The International Classification of Diseases (ICD) relies on clinical features and lags behind the current understanding molecular specificity disease pathobiology, necessitating approaches that incorporate growing biomedical data for classifying diseases to meet needs precision medicine. Our analysis revealed heterogeneous diversity chapters blurred boundary between categories in ICD should be further investigated. Here, we propose a new classification (NCD) by developing an algorithm...
Abstract The early diagnosis and investigation of the pathogenic mechanisms complex diseases are most challenging problems in fields biology medicine. Network-based systems is an important technique for study diseases. present constructed dynamic protein-protein interaction (PPI) networks to identify dynamical network biomarkers (DNBs) analyze underlying from a level. We developed model-based framework construction series time-sequenced by integrating high-throughput gene expression data...
Background Chicken meat is one of the most consumed meats worldwide and poultry production increasing at an exponential rate. Reducing antibiotic usage has resulted in recurrence subclinical necrotic enteritis again influenced global production. Probiotics are potential substitutes that can be used to prevent enteriti. However, precise mechanism action probiotics information on which gut microbes confer this efficacy remain elusive. Methods results The animal model was reveal underlying...
Phlomoides rotata , a traditional Tibetan medicinal herb renowned for its anti-inflammatory and analgesic properties, exhibits distinct metabolite profiles across heterogeneous environments. However, the impacts of altitude slope orientation on secondary metabolism remain poorly understood. This study aimed to characterize variations in leaves under different elevations microclimates, providing mechanistic basis quality evaluation sustainable utilization. Metabolomic analysis was conducted...
Porcine circovirus 2 (PCV2) is the main pathogen of porcine circovirus-associated disease (PCVAD), which can cause considerable economic loss to pig industry. The diagnosis PCVAD complicated and requires a series clinical, pathological, virological methods. Therefore, rapid, highly sensitive, on-site, visual diagnostic approach would facilitate dealing with spread PCV2. In this study, we intended establish new effective PCV2 detection method through combining no specific equipment...
Measles virus (MV) is still an imposing threat to public health. The matrix (M) protein has been shown not only function as a structure block in the assembled MV virions, but also regulate viral RNA synthesis, playing important role MV's replication and assembly. In present study, we generated panel of IgG monoclonal antibodies (MAbs) against M successfully obtained one IgA MAb (5H7) from panel. Employing polarized Vero cells grown two-chamber transwell model, investigated whether M-specific...
Transcription factor IIF (TFIIF) cooperates with RNA polymerase II (pol II) during multiple stages of the transcription cycle including preinitiation complex assembly, initiation, elongation, and possibly termination recycling. Human TFIIF appears to be an α2β2 heterotetramer II-associating protein 74- 30-kDa subunits (RAP74 RAP30). From inspection its 517-amino-acid (aa) sequence, RAP74 subunit comprise separate N- C-terminal domains connected by a flexible loop. In this study, we present...
The aim of this study was to evaluate the embolic sequelae left atrial myxomas and their influence on diagnosis, treatment, prognosis. Seventy-eight patients were retrospectively investigated. According symptoms neurologic-imaging findings, these classified into 2 groups: embolism (15 patients, 19%) nonembolism (63 81%). time from first onset diagnosis (that is, duration symptoms) significantly longer in group than (105 ± 190 vs 23 18 d; P <0.01). divided types basis clinicopathologic...
The occurrence of pseudorabies (PR) caused by the PR virus (PRV) causes huge economic losses to pig industry in China. Moreover, potential threat PRV humans' health has received wide attention recently. prevalence two genotypes and application their corresponding live attenuated vaccines increase recombination possibility. In present study, a novel recombinant strain designed as HN-2019 was isolated from one sick piglet Hunan province, China, its genetic features pathogenicity were further...
Respiratory syncytial virus (RSV) is a serious respiratory pathogen in infants and young children worldwide. Currently, no licensed RSV vaccines are available. In this study, we explored stable prefusion conformation virus-like particles (Pre-F VLPs) as vaccine candidates. fusion (F) protein mutants were constructed to form stabilized Pre-F or postfusion (Post-F) configurations. VLPs containing Post-F generated using recombinant baculovirus (rBV)-insect cell expression system. The assembly...