A5033348745- Cardiac Ischemia and Reperfusion
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Sperm and Testicular Function
- Cardiac and Coronary Surgery Techniques
- Traditional Chinese Medicine Analysis
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Caveolin-1 and cellular processes
- Renal Transplantation Outcomes and Treatments
- Aortic Disease and Treatment Approaches
- Cardiovascular Issues in Pregnancy
- Infectious Aortic and Vascular Conditions
- Metabolomics and Mass Spectrometry Studies
- Pericarditis and Cardiac Tamponade
- Nitric Oxide and Endothelin Effects
- Cardiovascular Effects of Exercise
- Neurological Disease Mechanisms and Treatments
- Gout, Hyperuricemia, Uric Acid
- Inflammatory Biomarkers in Disease Prognosis
- Musculoskeletal synovial abnormalities and treatments
- Calpain Protease Function and Regulation
- Genomics, phytochemicals, and oxidative stress
- Cardiac Valve Diseases and Treatments
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2015-2025
Heidelberg University
2018-2024
Affiliated Hospital of Shaanxi University of Chinese Medicine
2022
Shaanxi University of Chinese Medicine
2021-2022
First Affiliated Hospital of Zhengzhou University
2021
First Affiliated Hospital of Chengdu Medical College
2021
Beckman Coulter Foundation
2018
Obstructive sleep apnea (OSA) is a highly prevalent disorder associated with increased risk for cardiovascular disease, diabetes, and other chronic conditions. Unfortunately, up to 90% of individuals OSA remain without diagnosis or therapy. We assess the relationship between blood biomarkers, test hypothesis that combinations markers provide characteristic signature diagnostic screening value. This validation study was conducted in an independent cohort order replicate findings from prior...
The efficacy of a completely zero-fluoroscopy (ZF) approach for the catheter ablation idiopathic ventricular arrhythmias (VAs) and whether it has advantages over conventional fluoroscopy (F) are still unknown. aim this study was to compare safety ZF with those F in VAs.We conducted prospective involving 7 centers China. Consecutive patients (n = 489, mean age 45.3 ± 15.3 years, 44.8% male) VAs were recruited. Eligible participants assigned either 163) or 326) at ratio 1:2. successful 163...
Sperm DNA integrity is an essential factor for accurate transmission of genetic information. Human sperm damage a common cause male infertility but the exact mechanism remains poorly understood. Considering vital role microRNA (miRNA) in multiple pathophysiological processes, we hypothesised that testicular miRNA involved during spermatogenesis. Infertile patients with high fragment index (DFI; n=94) were selected from 1090 infertile men and total 18 testis-specific seminal miRNAs previously...
Zishen Yutai Pill (ZYP), containing 15 Chinese traditional medicine, is a safe and well quality-controlled TCM preparation with promising effects in many fields of reproduction. The current study was designed to investigate the therapeutic ZYP on sperm quality testis varicocele (VC) rats.Male Wistar rats were randomly divided into four groups (n = 6), i.e., sham group, VC treated different dose (1575 3150 mg/kg/d, respectively). experimental model established by partial ligation left renal...
Salvianolic acid A (Sal-A), salvianolic B (Sal-B) and danshensu (DSS) are the main active monomers of Salvia miltiorrhiza, a plant used in treatment myocardial infarction (MI). mixture design Sal-A, Sal-B, DSS was evaluated to determine optimal proportion three for protection efficacy. Regression models were established based on experimental data obtained from oxygen-glucose deprivation H9c2 cells. The response variables included cell viability, creatine kinase MB isoenzyme (CK-MB), cardiac...
Despite the widespread use of doxorubicin (DOX) in chemotherapy, it can cause cardiotoxicity, which severely limits its potential clinical use. CYP2J2-derived epoxyeicosatrienoic acids (EETs) exert cardioprotective effects by maintaining cardiac homeostasis. The roles and latent mechanisms EETs DOX cardiotoxicity remain uncertain. We investigated these aspects using mouse tissue cell culture models.
Salvia miltiorrhiza (SM) coupled with Dalbergia odorifera (DO) has been used to relieve cardiovascular diseases in China for many years. Our previous studies have integrated that SM-the volatile oil of DO (SM-DOO)-has a cardioprotective effect on chronic myocardial ischemia based pharmacological method, but the mechanism not elucidated completely metabonomic method. In present study, method high-performance liquid chromatography time-of-flight mass spectrometry (HPLC-Q-TOF-MS) was performed...
Long-term graft patency determines the prognosis of revascularization after coronary artery bypass grafting (CABG). Ischemia-reperfusion (I/R) injury suffered during harvesting and implantation might influence patency. Aspirin, a nonsteroidal anti-inflammatory drug improves long-term vein grafts. Whether aspirin has same effect on arterial grafts is questionable. We aimed to characterize beneficial effects in rodent model. gave Lewis rats oral pretreatment either (n = 8) or saline for 5...
Introduction Coronary artery bypass grafting (CABG) is the most common cardiac surgical procedure. The prognosis of revascularization via CABG determined by patency used grafts, for which an intact endothelium essential. degree ischemia-reperfusion injury (IRI), occurs during harvest and implantation important determinant graft patency. Preconditioning with aspirin, a nonsteroidal anti-inflammatory drug has been shown to reduce functional molecular damage arterial grafts in rodent model....
Background: The most durable treatment for coronary artery disease is bypass grafting (CABG), which the common cardiac surgical procedure. patency of used grafts, an intact endothelial layer essential, a key factor in prognosis CABG. Short- and long-term outcomes may be limited by degree ischemia-reperfusion injury (IRI), occurs during harvest implantation grafts leads to damage. It has been previously shown rodent model revascularization that with nonsteroidal anti-inflammatory drug aspirin...
Caveolin-3 is protein on the membrane of cardiac myocytes correlated with a variety cardiovascular diseases. The functional significance Cav-3 has been proved by fact that overexpression or knockdown results in occurrence and development disease. Mutations gene encoding cause broad spectrum clinical phenotypes, ranging from isolated hyperCKemia to most cardiomyopathy effect cav-3 mutations current density parallels channel trafficking. gene, such as F97C S141R, promote ventricular...
Ischaemia-reperfusion injury impairs the nitric oxide/soluble guanylate cyclase/cyclic guanosine monophosphate (cGMP) signalling pathway and leads to vascular dysfunction. We assessed hypothesis that soluble cyclase activator cinaciguat would protect graft against ischaemia-reperfusion injury.In treatment groups, rats (n = 8/group) were pretreated with either intravenous saline or (10 mg/kg) 2 h before an aortic transplant. Aortic grafts stored for in transplanted into abdominal aorta of...
Objectives: Oxidative stress interferes with nitric oxide (NO)/soluble guanylate cyclase (sGC)/cyclic guanosine monophosphate (cGMP) signaling pathway through reduction of endogenous NO and formation peroxynitrite leads to vascular dysfunction. We assessed the hypothesis that sGC activator cinaciguat would protect graft against IR injury in vessel wall bypass graft.