A5066370449- Aortic Disease and Treatment Approaches
- Connective tissue disorders research
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Infectious Aortic and Vascular Conditions
- Cardiovascular Issues in Pregnancy
- Cardiomyopathy and Myosin Studies
- Elasticity and Material Modeling
- Cardiac Structural Anomalies and Repair
Marfan Foundation
2025
Semmelweis University
2022-2025
Foundation for People with Rare Diseases
2023-2024
Aortic dissection occurs rarely during pregnancy but carries a significantly high vital risk for both the mother and fetus. Early diagnosis treatment are critical successful outcome. A 32-year-old pregnant woman at 31 weeks of gestation began experiencing shortness breath, chest pain, palpitations, which were attributed to an anxiety disorder she had been previously diagnosed with. The symptoms continued worsen following delivery when computed tomography investigation revealed signs chronic...
Marfan syndrome (MFS) is an autosomal dominant disease caused by mutations in the gene (FBN1) of fibrillin-1, a major determinant extracellular matrix (ECM). Functional impairment cardiac left ventricle (LV) these patients usually consequence aortic valve disease. However, LV passive stiffness may also be affected chronic changes mechanical load and ECM dysfunction. Passive determined giant sarcomeric protein titin that has two main splice isoforms: shorter stiffer N2B longer more compliant...
Hereditary aortic diseases (hADs) increase the risk of dissections and ruptures. Recently, we have established an objective approach to measure rupture force murine aorta, thereby explaining outcomes clinical studies assessing added value approved drugs in vascular Ehlers-Danlos syndrome (vEDS). Here, applied our six additional mouse hAD models. We used two models (Fbn1C1041G Fbn1mgR ) Marfan (MFS) as well one smooth-muscle-cell-specific knockout (SMKO) Efemp2 three CRISPR/Cas9-engineered...
Introduction Coronary artery bypass grafting (CABG) is the most common cardiac surgical procedure. The prognosis of revascularization via CABG determined by patency used grafts, for which an intact endothelium essential. degree ischemia-reperfusion injury (IRI), occurs during harvest and implantation important determinant graft patency. Preconditioning with aspirin, a nonsteroidal anti-inflammatory drug has been shown to reduce functional molecular damage arterial grafts in rodent model....
Background: The most durable treatment for coronary artery disease is bypass grafting (CABG), which the common cardiac surgical procedure. patency of used grafts, an intact endothelial layer essential, a key factor in prognosis CABG. Short- and long-term outcomes may be limited by degree ischemia-reperfusion injury (IRI), occurs during harvest implantation grafts leads to damage. It has been previously shown rodent model revascularization that with nonsteroidal anti-inflammatory drug aspirin...
Due to its heterogeneous clinical picture and lengthy evolution, the management of type B aortic dissection represents a challenge, often calling for complex strategies combining medical, endovascular, open surgical strategies. We present case 45-year-old female who had previously suffered complicated requiring femoro-femoral crossover bypass further conservative treatment. Seven years later, due an aneurysmal development, staged descending was strategized, beginning with implantation frozen...
ABSTRACT OBJECTIVE Hereditary aortic diseases (hADs) increase the risk of dissections and ruptures. Recently, we have established an objective approach to measure rupture force murine aorta, thereby explaining outcomes clinical studies assessing added value approved drugs in vascular Ehlers-Danlos syndrome (vEDS). Here, applied our six additional mouse hAD models. APPROACH AND RESULT We used two models Marfan (MFS) as well one smooth-muscle-cell-specific knockout (SMKO) Efemp2 three...