A5090573335- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Connective tissue disorders research
- Aortic aneurysm repair treatments
- Cardiac Structural Anomalies and Repair
- Diabetes Treatment and Management
- Pulmonary Hypertension Research and Treatments
- Cardiac Ischemia and Reperfusion
- Transplantation: Methods and Outcomes
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Pancreatic function and diabetes
- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Cardiac and Coronary Surgery Techniques
- Thyroid Disorders and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Issues in Pregnancy
- Nitric Oxide and Endothelin Effects
- Fuel Cells and Related Materials
- Metabolism, Diabetes, and Cancer
- Potassium and Related Disorders
- Cardiac Fibrosis and Remodeling
- Peripheral Artery Disease Management
Semmelweis University
2016-2025
Marfan Foundation
2015-2025
Martin Luther University Halle-Wittenberg
2022-2024
University Hospital in Halle
2023
Heidelberg University
2016
Development Fund
2016
Animal Health Trust
2003
The sodium–glucose cotransporter-2 (SGLT2) inhibitor canagliflozin has been shown to reduce major cardiovascular events in type 2 diabetic patients, with a pronounced decrease hospitalization for heart failure (HF) especially those HF at baseline. These might indicate potent direct cardioprotective effect, which is currently incompletely understood. We sought characterize the effects of acute treatment healthy and infarcted rat hearts. Non-diabetic male rats were subjected sham operation or...
Measurement of systolic and diastolic function in animal models is challenging by conventional non-invasive methods. Therefore, we aimed at comparing speckle-tracking echocardiography (STE)-derived parameters to the indices left ventricular (LV) pressure–volume (PV) analysis detect cardiac dysfunction rat type-1 (T1DM) type-2 (T2DM) diabetes mellitus. Rat T1DM (induced 60 mg/kg streptozotocin, n = 8) T2DM (32-week-old Zucker Diabetic Fatty rats, 7) corresponding control animals (n 5 8,...
Abstract Background Whereas selective sodium-glucose cotransporter 2 (SGLT2) inhibitors consistently showed cardiovascular protective effects in large outcome trials independent of the presence type diabetes mellitus (T2DM), dual SGLT1/2 remain to be elucidated. Despite its clinical relevance, data are scarce regarding left ventricular (LV) SGLT1 expression distinct heart failure (HF) pathologies. We aimed characterize LV human patients with end-stage HF, context other two major glucose...
Aortic dissection occurs rarely during pregnancy but carries a significantly high vital risk for both the mother and fetus. Early diagnosis treatment are critical successful outcome. A 32-year-old pregnant woman at 31 weeks of gestation began experiencing shortness breath, chest pain, palpitations, which were attributed to an anxiety disorder she had been previously diagnosed with. The symptoms continued worsen following delivery when computed tomography investigation revealed signs chronic...
Marfan syndrome (MFS) is an autosomal dominant disease caused by mutations in the gene (FBN1) of fibrillin-1, a major determinant extracellular matrix (ECM). Functional impairment cardiac left ventricle (LV) these patients usually consequence aortic valve disease. However, LV passive stiffness may also be affected chronic changes mechanical load and ECM dysfunction. Passive determined giant sarcomeric protein titin that has two main splice isoforms: shorter stiffer N2B longer more compliant...
Abstract The ACTA2 gene encodes for smooth muscle specific α-actin, a critical component of the contractile apparatus vascular cell. Pathogenic variants in are most frequently encountered genetic cause non-syndromic hereditary thoracic aortic disease (HTAD). Although aneurysm and/or dissection is main clinical manifestation, variety occlusive and extravascular manifestations occur -related vasculopathy. Current data suggest possible mutation-specific extra-aortic traits. Despite its...
Abstract Background Marfan syndrome (MFS) is a systemic connective tissue disorder with life-threatening manifestations affecting the ascending aorta. MFS caused by dominant negative (DN) and haploinsufficient (HI) mutations of FBN1 gene. Our aim was to identify patients high detection rate investigate use gene panel for Marfanoid habitus. We also aimed examine correlations between genotype cardiovascular predict “malignant” mutations. Methods 136 individuals were enrolled. In first phase,...
Objectives Our aim was to assess the procedural success and determine clinical predictors of postprocedure mortality, following rotational atherectomy (RA) stenting in high-risk patients. Background RA is mainly used facilitate complex lesions. Outcomes involving have been investigated, yet patients not adequately described. Methods Data 218 consecutive who underwent were evaluated a prospective register. Primary endpoints angiographic long-term mortality. Secondary success, consumption...
Heritable thoracic aortic diseases (HTAD) are rare pathologies associated with aneurysms and dissection, which can be syndromic or non-syndromic. They may result from genetic defects. Associated genes identified to date classified into those encoding components of the (a) extracellular matrix (b) TGFβ pathway (c) smooth muscle contractile mechanism. Timely diagnosis allows for prompt surveillance prophylactic surgery, hence improving life expectancy reducing maternal complications as well...
Orthotopic heart transplantation (HTx) is a long-term surgical therapeutic approach for patients with end-stage failure. The objective of the present study was to uncover associations between altered thyroid hormone (TH) status and adverse outcomes after HTx.
Marfan syndrome is a genetic disease, presenting with dysfunction of connective tissues leading to lesions in the cardiovascular and skeletal muscle system. Within these symptoms, most typical weakness tissue aorta, manifesting as aortic dilatation (aneurysm). This could, turn, become annuloaortic ectasia, or life-threatening dissection. As result, life-saving preventative cardiac surgical interventions are frequent among patients. Aortic aneurysm could turn into ectasia dissection, thus...
We retrospectively analyzed 25 years of experiences with the button Bentall procedure in patients aortic root pathologies. Even though this has become widespread, there are only a few very long term follow-ups available clinical literature, especially regarding single surgeon results. Between 1988 and 2013, total 147 underwent by same surgeon. Among them were 62 Marfan syndrome. At time surgery mean age was 46.5 ± 17.6 years. The impact surgical experience on long-term survival evaluated...
Long-term exercise training is associated with characteristic cardiac adaptation, termed athlete's heart. Our research group previously characterized in vivo left ventricular (LV) function of exercise-induced hypertrophy detail a rat model; however, the effect detraining on LV still unclear. We aimed at evaluating reversibility functional alterations heart after detraining.Rats (n = 16) were divided into detrained exercised (DEx) and control (DCo) groups. Trained rats swam 200 min·d for 12...
Fabry disease is an X-linked lysosomal storage disorder, causing accumulation of globotriaosylceramid in different organs. Glycolipids are activators immune cell subsets the resulting inflammation responsible for organ damage. Pulmonary involvement leads to airway inflammation; however, data on severity, as well effect enzyme replacement therapy lung function parameters and changes peripheral sparse.Seven patients four carriers underwent detailed clinical examinations screening pulmonary...
Abstract Background Clinical evidence suggests that the currently recommended approach to estimate risk of aortic dissection in Marfan syndrome (MFS) is not reliable enough. Therefore, we investigated possible role visceral arterial tortuosity stratification. Methods and results Splenic renal arteries 37 MFS patients 74 age gender matched control subjects were segmented using CT angiography imaging. To measure tortuosity, distance metric (DM), sum angles (SOAM), inflection count (ICM), ratio...
The authors' aim was to examine the preoperative hormone and nutritional status in patients undergoing elective cardiac surgery.The research a single-center, prospective, observational study (ClinicalTrials.gov: NCT03736499).The authors examined 252 who underwent surgery. Preoperative thyroid-stimulating (TSH), free triiodothyronine (fT3), thyroxine (fT4), prolactin, testosterone levels were collected analyzed after Geriatric Nutritional Risk Index (GNRI), Controlling Status (CONUT),...
Summary Folic acid metabolism enzyme polymorphisms are believed to be responsible for the elevation of homocysteine (HCY) concentration in blood plasma, correlating with pathogenesis aortic aneurysms and dissection. We studied 71 Marfan patients divided into groups based on severity cardiovascular involvement: no intervention required (n=27, Group A); mild involvement requiring (n=17, B); severe C) subdivided dilatation (n=14, C1) dissection (n=13, C2), as well 117 control subjects....
Copy number variations (CNVs) comprise about 10% of reported disease-causing mutations in Mendelian disorders. Nevertheless, pathogenic CNVs may have been under-detected due to the lack or insufficient use appropriate detection methods. In this report, on example diagnostic odyssey a patient with Marfan syndrome (MFS) harboring hitherto unreported 32-kb FBN1 deletion, we highlight need for and feasibility testing (>1 kb) disorders current next-generation sequencing (NGS) era.
Abstract Background Sinus of Valsalva aneurysm (SVA) is an uncommon cardiac anomaly, with incidence less than 1% open heart surgery cases. Its evolution most frequently silent, being found incidentally or discovered in the event its acute rupture. Non-ruptured giant SVAs may cause unusual clinical manifestations, as a consequence their protrusion into chambers compression coronary vessels and are associated aortic insufficiency various degrees severity. The gold standard treatment for...