A5030214119- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Liver Disease and Transplantation
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Sports injuries and prevention
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Rheumatoid Arthritis Research and Therapies
- Mitochondrial Function and Pathology
- Cardiac Ischemia and Reperfusion
- Osteoarthritis Treatment and Mechanisms
- Gout, Hyperuricemia, Uric Acid
- Peripheral Artery Disease Management
- Abdominal Trauma and Injuries
- Cerebrovascular and Carotid Artery Diseases
- Trauma and Emergency Care Studies
- Drug Transport and Resistance Mechanisms
- Sulfur Compounds in Biology
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Diversity and Impact of Dance
- Heme Oxygenase-1 and Carbon Monoxide
- Traumatic Brain Injury and Neurovascular Disturbances
- Eicosanoids and Hypertension Pharmacology
- Orthopedic Infections and Treatments
University of Szeged
2016-2024
Mitochondria are targets of cold ischemia-reperfusion (IR), the major cause cell damage during static preservation liver allografts. The bioactivity methane (CH4) has recently been recognized in various hypoxic and IR conditions as having influence on many aspects mitochondrial biology. We therefore hypothesized that storage grafts CH4-enriched solution can provide an increased defence against organ dysfunction a preclinical rat model transplantation. Livers were preserved for 24 h...
There is growing evidence regarding the role of mitochondrial dysfunction in osteoarthritis (OA) and rheumatoid arthritis (RA). However, quantitative comparison synovial derangements these main forms missing. A prospective clinical study was conducted on adult patients undergoing knee surgery. Patients were allocated into RA OA groups based disease-specific scores, while without served as controls. Synovial samples subjected to high-resolution respirometry analyze functions. From total 814...
Albeit previous experiments suggest potential anti-inflammatory effect of exogenous methane (CH4 ) in various organs, the mechanism its bioactivity is not entirely understood. We aimed to investigate mitochondrial effects and underlying mechanisms CH4 rat cardiomyocytes mitochondria under simulated ischaemia/reperfusion (sI/R) conditions. Three-day-old cultured were treated with 2.2% -artificial air mixture during 2-hour-long reoxygenation following 4-hour-long anoxia (sI/R sI/R + , n =...
Despite their clinical effectiveness, a growing body of evidence has shown that many classes antibiotics lead to mitochondrial dysfunction. Ceftriaxone and Rifaximin are first choice perioperative in gastrointestinal surgery targeting fundamental processes intestinal bacteria; however, may also have negative consequences for the host cells. In this study, we investigated direct effect on functions vitro, together with impact ileum, colon liver tissue. Additionally, microbiome was studied...
Absztrakt A mitochondriumok kulcsfontosságú élettani feladataiknál fogva oki szerepet játszanak számos akut és krónikus májbetegség kialakulásában, így e sejtalkotók terápiás lehetséges diagnosztikus célpontok is egyben. Jelen tanulmányunk során bemutatunk egy vizsgálómódszert, amely nagy felbontású respirométer (oxigráf) segítségével lehetővé teszi a mitochondrialis funkciók értékelését. vizsgálatok friss szövetminták oxigénfogyasztásának meghatározása alapján az oxidatív foszforilációt...
Purpose: There is growing evidence for the role of mitochondrial dysfunction in osteoarthritis (OA) and rheumatoid arthritis (RA). However, quantitative comparison derangements these main forms clinical settings missing. Therefore, our aim was to characterize altered functions synovial membranes OA RA patients. Methods: Synovial tissue samples were taken intraoperatively subjected high-resolution respirometry (Oxygraph-2k, Oroboros Instruments, Austria) analyze oxygen consumption. The...