A5075253705- Colorectal Cancer Screening and Detection
- Osteoarthritis Treatment and Mechanisms
- Rheumatoid Arthritis Research and Therapies
- Genetic factors in colorectal cancer
- Cardiac Ischemia and Reperfusion
- Antibiotic Resistance in Bacteria
- Liver Disease and Transplantation
- Orthopedic Infections and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Venous Thromboembolism Diagnosis and Management
- Inflammatory Bowel Disease
- Digestive system and related health
- Antibiotics Pharmacokinetics and Efficacy
- Insects and Parasite Interactions
- Parasitic Diseases Research and Treatment
- Organ Transplantation Techniques and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- Gout, Hyperuricemia, Uric Acid
- COVID-19 diagnosis using AI
- Drug Transport and Resistance Mechanisms
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
University of Szeged
2021-2024
Mitochondria are targets of cold ischemia-reperfusion (IR), the major cause cell damage during static preservation liver allografts. The bioactivity methane (CH4) has recently been recognized in various hypoxic and IR conditions as having influence on many aspects mitochondrial biology. We therefore hypothesized that storage grafts CH4-enriched solution can provide an increased defence against organ dysfunction a preclinical rat model transplantation. Livers were preserved for 24 h...
There is growing evidence regarding the role of mitochondrial dysfunction in osteoarthritis (OA) and rheumatoid arthritis (RA). However, quantitative comparison synovial derangements these main forms missing. A prospective clinical study was conducted on adult patients undergoing knee surgery. Patients were allocated into RA OA groups based disease-specific scores, while without served as controls. Synovial samples subjected to high-resolution respirometry analyze functions. From total 814...
Despite their clinical effectiveness, a growing body of evidence has shown that many classes antibiotics lead to mitochondrial dysfunction. Ceftriaxone and Rifaximin are first choice perioperative in gastrointestinal surgery targeting fundamental processes intestinal bacteria; however, may also have negative consequences for the host cells. In this study, we investigated direct effect on functions vitro, together with impact ileum, colon liver tissue. Additionally, microbiome was studied...
Human pulmonary dirofilariasis (HPD) is rare in Hungary, and it stems from Dirofilaria immitis, mainly transmitted through mosquito bites, with dogs as primary hosts. Despite its prevalence veterinary settings, human cases are infrequent. Historically, Mediterranean countries report most HPD cases, but sporadic occur temperate European regions. Radiologically, often manifests a non-specific manner, resembling neoplasms, leading to unnecessary surgery patient distress.
<title>Abstract</title> Objective Histopathological growth patterns (HGPs) in liver metastases have been identified to prognostic value; however, they currently do not influence therapeutic decisions, and the literature mainly focuses on colorectal adenocarcinoma metastases. Hitherto, only examined a consecutive setting 5 studies. Methods Patients between 2011 2016 were included with ICD code C7870. General clinicopathological data obtained from medical charts. Histological slides of...
A gyulladásos bélbetegséggel (IBD) élő betegekben a colorectalis carcinoma kialakulásának esélye az átlagpopulációban észleltek kétszerese. Az invazív daganatokat megelőzően ezekben nagyobb rizikó dysplasia kialakulására is. utóbbi években számos, IBD-hez társult, ún. non-conventionalis altípust azonosítottak, melyekről jelenleg is zajló kutatásoknak köszönhetően egyre több információval rendelkezünk. Egy 62 éves, 14 éve relabáló colitis ulcerosával diagnosztizált és kezelt nőbeteg...
Összefoglaló. Bevezetés: A kórboncolás hozzájárul a súlyos akut légzőszervi szindrómát okozó koronavírus-2 (SARS-CoV-2-) fertőzés klinikopatológiai vonatkozásainak megismeréséhez. Célkitűzés: SARS-CoV-2-fertőzöttek boncolása során gyűjtött tapasztalatok bemutatása. Módszer: Egymást követően boncolt, védőoltásban nem részesült, SARS-CoV-2-fertőzött elhunytak klinikai adatait, makro- és mikroszkópos észleleteit összegeztük; tüdőkimetszéseket SARS-CoV-2-nukleokapszid-immunfestéssel vizsgáltuk....
Purpose: There is growing evidence for the role of mitochondrial dysfunction in osteoarthritis (OA) and rheumatoid arthritis (RA). However, quantitative comparison derangements these main forms clinical settings missing. Therefore, our aim was to characterize altered functions synovial membranes OA RA patients. Methods: Synovial tissue samples were taken intraoperatively subjected high-resolution respirometry (Oxygraph-2k, Oroboros Instruments, Austria) analyze oxygen consumption. The...