A5026682863- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Cardiovascular and exercise physiology
- Cardiac Fibrosis and Remodeling
- Diabetes Treatment and Management
- Nitric Oxide and Endothelin Effects
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Adhesion, Friction, and Surface Interactions
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Cardiovascular Health and Disease Prevention
- Metabolism, Diabetes, and Cancer
- Tribology and Wear Analysis
- Cardiovascular Disease and Adiposity
- Pulmonary Hypertension Research and Treatments
- MicroRNA in disease regulation
- Cardiac pacing and defibrillation studies
- Hormonal Regulation and Hypertension
- Force Microscopy Techniques and Applications
- Surface Modification and Superhydrophobicity
- Circular RNAs in diseases
- Acute Myocardial Infarction Research
Semmelweis University
2015-2024
University of Pecs
2018
Heidelberg University
2016-2018
Heidelberg University
2018
Development Fund
2016
University of Twente
2003-2005
Institute of Polymers
2002-2004
University Hospital of Zurich
1992-1993
Chemical force microscopy (CFM) in water was used to map the surface hydrophobicity of UV/ozone-treated poly(dimethylsiloxane) (PDMS; Sylgard 184) as a function storage/recovery time. In addition CFM pull-off mapping, we applied indentation mapping probe changes normalized modulus. These experiments were complemented by results on properties assessed micrometer scale X-ray photoelectron spectroscopy and contact-angle measurements. Exposure times < or = 30 min resulted laterally homogeneously...
The sodium–glucose cotransporter-2 (SGLT2) inhibitor canagliflozin has been shown to reduce major cardiovascular events in type 2 diabetic patients, with a pronounced decrease hospitalization for heart failure (HF) especially those HF at baseline. These might indicate potent direct cardioprotective effect, which is currently incompletely understood. We sought characterize the effects of acute treatment healthy and infarcted rat hearts. Non-diabetic male rats were subjected sham operation or...
Abstract Aims Heart failure with preserved ejection fraction ( HFpEF ) has a great epidemiological burden. The pathophysiological role of cyclic guanosine monophosphate cGMP signalling been intensively investigated in . Elevated levels have shown to exert cardioprotective effects various cardiovascular diseases, including diabetic cardiomyopathy. We the effect long‐term preventive application phosphodiesterase‐ 5A PDE5A inhibitor vardenafil cardiomyopathy‐associated Methods and results...
Although incidence and prevalence of prediabetes are increasing, little is known about its cardiac effects. Therefore, our aim was to investigate the effect on function characterize parameters pathways associated with deteriorated performance. Long-Evans rats were fed either control or high-fat chow for 21 wk treated a single low dose (20 mg/kg) streptozotocin at week 4 High-fat treatment induced as characterized by slightly elevated fasting blood glucose, impaired glucose insulin tolerance,...
Long-term exercise training is associated with characteristic structural and functional changes of the myocardium, termed athlete's heart. Several research groups investigated training-induced left ventricular (LV) hypertrophy in animal models; however, only sporadic data exist about detailed hemodynamics. We aimed to provide characterization exercise-induced cardiac a rat model using vivo method LV pressure-volume (P-V) analysis. After inducing by swim training, we assessed morphometry...
Contractile function is considered to be precisely measurable only by invasive hemodynamics. We aimed correlate strain values measured speckle-tracking echocardiography (STE) with sensitive contractility parameters of pressure-volume (P-V) analysis in a rat model exercise-induced left ventricular (LV) hypertrophy. LV hypertrophy was induced rats swim training and compared untrained controls. Echocardiography performed using 13-MHz linear transducer obtain long- short-axis recordings for STE...
Diabetes mellitus (DM) leads to the development of diabetic cardiomyopathy, which is associated with altered nitric oxide (NO)--soluble guanylate cyclase (sGC)--cyclic guanosine monophosphate (cGMP) signalling. Cardioprotective effects elevated intracellular cGMP-levels have been described in different heart diseases. In current study we aimed at investigating pharmacological activation sGC cardiomyopathy.Type-1 DM was induced rats by streptozotocin. Animals were treated either activator...
Measurement of systolic and diastolic function in animal models is challenging by conventional non-invasive methods. Therefore, we aimed at comparing speckle-tracking echocardiography (STE)-derived parameters to the indices left ventricular (LV) pressure–volume (PV) analysis detect cardiac dysfunction rat type-1 (T1DM) type-2 (T2DM) diabetes mellitus. Rat T1DM (induced 60 mg/kg streptozotocin, n = 8) T2DM (32-week-old Zucker Diabetic Fatty rats, 7) corresponding control animals (n 5 8,...
Abstract Background Whereas selective sodium-glucose cotransporter 2 (SGLT2) inhibitors consistently showed cardiovascular protective effects in large outcome trials independent of the presence type diabetes mellitus (T2DM), dual SGLT1/2 remain to be elucidated. Despite its clinical relevance, data are scarce regarding left ventricular (LV) SGLT1 expression distinct heart failure (HF) pathologies. We aimed characterize LV human patients with end-stage HF, context other two major glucose...
We sought to investigate the correlation between speckle-tracking echocardiography (STE)-derived myocardial work (MW) and invasively measured contractility in a rat model of athlete's heart. also assessed MW elite athletes explored its association with cardiopulmonary exercise test (CPET)-derived aerobic capacity.Sixteen rats underwent 12-week swim training program were compared controls (n = 16). STE was performed assess global longitudinal strain (GLS), which followed by invasive...
Left ventricular (LV) hypertrophy is a physiological or pathological response of LV myocardium to increased cardiac load. We aimed at investigating and comparing hemodynamic alterations in well-established rat models (PhyH) (PaH) by using pressure-volume (P-V) analysis. PhyH PaH were induced rats swim training abdominal aortic banding, respectively. Morphology the heart was investigated echocardiography. Characterization function completed P-V In addition, histological molecular biological...
•LV contractility and afterload are both major determinants of LS LSSr.•In hemodynamic overload–induced HF, altered.•Thus, under these conditions, LSSr reflect VAC rather than mere contractility. BackgroundLongitudinal strain (LS) is a sensitive marker systolic function. Recent findings suggest that myocardial loading conditions determine LS. The aim this study was to investigate whether reflects the connection cardiac (termed ventriculoarterial coupling [VAC]) in rat models heart failure...
Abstract Aims While global longitudinal strain (GLS) is considered to be a sensitive marker of left ventricular (LV) function, it significantly influenced by loading conditions. We hypothesized that myocardial work index (GMWI), novel LV may show better correlation with load‐independent markers contractility in rat models pressure‐induced or volume overload‐induced heart failure. Methods and results Male Wistar rats underwent either transverse aortic constriction (TAC; n = 12) aortocaval...
Although exercise-induced cardiac hypertrophy has been intensively investigated, its development and regression dynamics have not comprehensively described. In the current study, we aimed to characterize effects of regular exercise training detraining on left ventricular (LV) morphology function.Rats were divided into exercised (n = 12) control groups. Exercised rats swam 200 min/day for 12 weeks. After completion protocol, remained sedentary 8 weeks (detraining period). Echocardiographic...
Background: Recent evidences suggest that sex hormones may be involved in the regulation of exercise-induced left ventricular (LV) hypertrophy. However, sex-specific functional consequences myocardial hypertrophy is still not investigated detail. We aimed at understanding and morphological alterations LV underlying molecular changes a rat model athlete's heart. Methods: divided our young, adult male female rats into control exercised groups. Athlete's heart was induced by 12-week long swim...
Abstract Omecamtiv mecarbil (OM) is a promising novel drug for improving cardiac contractility. We tested the therapeutic range of OM and identified previously unrecognized side effects. The Ca 2+ sensitivity isometric force production (pCa 50 ) at low levels increased with concentration in human permeabilized cardiomyocytes. (1 µM) slowed kinetics contractions relaxations evoked an oscillation between normal reduced intracellular transients, action potential lengths isolated canine...
Increasing evidence suggests that both types of diabetes mellitus (DM) lead to cardiac structural and functional changes. In this study we investigated compared characteristics underlying subcellular pathological features in rat models type-1 type-2 diabetic cardiomyopathy. Type-1 DM was induced by streptozotocin. For DM, Zucker Diabetic Fatty (ZDF) rats were used. Left ventricular pressure-volume analysis performed assess function. Myocardial nitrotyrosine immunohistochemistry, TUNEL assay,...
Abstract Pathologic myocardial hypertrophy develops when the heart is chronically pressure-overloaded. Elevated intracellular cGMP-levels have been reported to prevent development of pathologic hypertrophy, therefore we investigated effects chronic activation cGMP producing enzyme, soluble guanylate cyclase by Cinaciguat in a rat model pressure overload-induced cardiac hypertrophy. Abdominal aortic banding (AAB) was used evoke male Wistar rats. Sham operated animals served as controls....