A5037591051- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Carbohydrate Chemistry and Synthesis
- Cardiac Arrhythmias and Treatments
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Synthesis of Organic Compounds
- Cardiac Ischemia and Reperfusion
- DNA and Nucleic Acid Chemistry
- Electrochemical Analysis and Applications
- Enzyme Production and Characterization
- Genomics and Chromatin Dynamics
- Ion Channels and Receptors
- Glycosylation and Glycoproteins Research
- Heat shock proteins research
- Analytical Chemistry and Sensors
- ECG Monitoring and Analysis
- Chemical Synthesis and Analysis
- Muscle activation and electromyography studies
- Heart Rate Variability and Autonomic Control
- DNA Repair Mechanisms
- Cardiovascular Function and Risk Factors
University of Debrecen
2016-2025
Semmelweis University
2003
Egis Pharmaceuticals (Hungary)
2001
Servier (France)
2001
Institut des Hautes Études Scientifiques
2001
University of Cincinnati Medical Center
1990-1993
UiT The Arctic University of Norway
1992
Institute of Biochemistry
1973-1984
Institute of Organic Chemistry
1953-1961
The aim of the present study was to compare apico-basal distribution ion currents and underlying channel proteins in canine human ventricular myocardium.Ion action potentials were recorded cardiomyocytes, isolated from both apical basal regions heart, using whole-cell voltage clamp techniques. Density myocardium determined by Western blotting.Action potential duration shorter magnitude phase-1 repolarization significantly higher than myocytes. No differences observed other parameters or cell...
Abstract The methylated analogues of ß‐cyclodextrin dissolve in cold water 10 – 20 times better than itself, however, quite unusually on heating they crystallize from the solution. structure heptakis‐(2,6‐di‐O‐methyl)‐ and heptakis‐(2,3,6‐tri‐O‐methyl)‐ß‐cyclodextrin was proved by gas‐liquid chromatographic 1 H‐NMR 13 C‐NMR spectroscopic investigations. corresponding model compounds were synthetized and, according to investigations, a part so far published NMR assignations have be corrected.
Cardiac repolarization, through which heart-cells return to their resting state after having fired, is a delicate process, susceptible disruption by common drugs and clinical conditions. Animal models, particularly the dog, are often used study repolarization properties responses drugs, with assumption that such findings relevant humans. However, little known about applicability of in animals man. Here, we studied contribution various ion-currents cardiac canine human ventricle. Humans...
Transient receptor potential (TRP) ion channels were first characterized on neurons, where they are classically implicated in sensory functions; however, research recent decades has shown that many of these also expressed nonneuronal cell types. Emerging findings have highlighted the role TRP skin, been to be important numerous cutaneous functions. Of particular interest is TRPV3, which was described keratinocytes. Its functional importance supported when its gain-of-function mutation linked...
The cardiovascular effects and toxicity of tricyclic antidepressants (TCAs) have been well documented in medical literature. most common manifestation such is slowing intraventricular conduction, manifested by prolonged PR, QRS QT intervals on the standard electrocardiogram (ECG) postural hypotension. In contrast to TCAs, selective serotonin reuptake inhibitors (SSRIs), including fluoxetine citalopram, are considered cause less effect cardiac impulse conduction. addition, these compounds...
In diabetes mellitus several cardiac electrophysiological parameters are known to be affected. rodent experimental models changes in these were reported, but no such data available other mammalian species including the dog. The present study was designed analyse effects of type 1 on ventricular repolarization and its underlying transmembrane ionic currents channel proteins canine hearts.Diabetes induced by a single injection alloxan, subgroup dogs received insulin substitution. After...
The sodium-calcium exchanger (NCX) was considered to play an important role in arrhythmogenesis under certain conditions such as heart failure or calcium overload. In the present study, effect of SEA-0400, a selective inhibitor NCX, investigated on early and delayed afterdepolarizations canine ventricular papillary muscles Purkinje fibres by applying conventional microelectrode techniques at 37 degrees C. amplitude both markedly decreased 1 microM SEA-0400 from 26.6+/-2.5 14.8+/-1.8 mV (n=9,...
In this study the effects of a new, highly selective sodium-calcium exchanger (NCX) inhibitor, ORM-10962 were investigated on cardiac NCX current, Ca2+ transients, cell shortening and in experimental arrhythmias. The level selectivity novel inhibitor several major transmembrane ion currents (L-type repolarizing K+ currents, late Na+ Na+/K+ pump current) was also determined.Ion single dog ventricular cells (cardiac myocytes; CM), action potentials multicellular preparations recorded utilizing...
The aim of the present study was to assess and compare dynamics L-type Ca(2+) current (I(Ca,L)) during physiologic action potential (AP) in canine ventricular cardiomyocytes epicardial (EPI) endocardial (ENDO) origin.I(Ca,L) recorded on cells derived from two regions heart using both AP voltage clamp conventional whole cell techniques.AP experiments revealed that decay I(Ca,L) is monotonic AP, whereas double-peaked (displaying a second rise) AP. amplitude first peak significantly greater...
Abstract Aim: The aim of the study was to examine effects testosterone and oestrogen on ECG parameters expression cardiac ion channels in male female dogs, compare dofetilide‐induced lengthening QTc interval control, castrated hormone‐treated animals. Methods: records were taken from anaesthetized dogs ( n = 10 each group) before castration, after following inverted hormone substitution. animals challenged with dofetilide at stage experiment. Finally, hearts excised studied using Western...
AimsClass III antiarrhythmic agents exhibit reverse rate-dependent lengthening of the action potential duration (APD). In spite several theories developed so far to explain this rate dependency (RRD), its mechanism has not yet been clarified. The aim present work was further elucidate mechanisms responsible for drug effects.
Background and Purpose Augmented Na + / Ca 2+ exchanger ( NCX ) activity may play a crucial role in cardiac arrhythmogenesis; however, data regarding the anti‐arrhythmic efficacy of inhibition are debatable. Feasible explanations could be unsatisfactory selectivity inhibitors and/or dependence experimental model on degree i overload. Hence, we used SEA 0400 more selective ORM 10103 to evaluate against arrhythmogenic rise conditions when [ ] was augmented via activation late sodium current I...