•LV contractility and afterload are both major determinants of LS LSSr.•In hemodynamic overload–induced HF, altered.•Thus, under these conditions, LSSr reflect VAC rather than mere contractility. BackgroundLongitudinal strain (LS) is a sensitive marker systolic function. Recent findings suggest that myocardial loading conditions determine LS. The aim this study was to investigate whether reflects the connection cardiac (termed ventriculoarterial coupling [VAC]) in rat models heart failure...

Abstract Aims While global longitudinal strain (GLS) is considered to be a sensitive marker of left ventricular (LV) function, it significantly influenced by loading conditions. We hypothesized that myocardial work index (GMWI), novel LV may show better correlation with load‐independent markers contractility in rat models pressure‐induced or volume overload‐induced heart failure. Methods and results Male Wistar rats underwent either transverse aortic constriction (TAC; n = 12) aortocaval...

Abstract Introduction Crohn’s disease (CD) with short bowel syndrome (SBS) can present as chronic intestinal failure (CIF) often requiring nutritional support. Teduglutide is a treatment option for these patients. We investigated clinical outcomes of CD-CIF patients SBS treated teduglutide. Methods Adults and who received teduglutide were identified at tertiary care academic center between 2012 2023. Data was collected retrospectively. Primary outcome measured reduction in parenteral support...

A man in his 60s presented to the emergency room with fever and fatigue after a 2.5-month course of corticosteroids. His medical history was significant for bioprosthetic aortic valve replacement moderately severe ulcerative colitis treated balsalazide daily lactobacillus-containing probiotics. Initial investigations revealed Lactobacillus rhamnosus bacteraemia without complication. Four days hospital discharge, patient experienced acute-onset right-sided paraesthesia lower-limb paresis. On...

INTRODUCTION: Hepatitis B virus (HBV) vaccination is recommended in patients with inflammatory bowel disease (IBD). Although the 2-dose Heplisav-B vaccine has proven effective, more than 20% of IBD do not seroconvert. We prospectively evaluated effectiveness a third dose lacking HBV immunity despite vaccination. METHODS: Adults who had received between 2018 and 2023 were identified. Seroconversion was defined as hepatitis surface antibody (HBsAb) ≥ 10 IU/L measured at ≥4 weeks after Patients...

Background Gastrointestinal manifestations of coronavirus disease 2019 (COVID-19) are increasingly recognized. Through potentially overlapping pathophysiology, co-occurrence COVID-19 and first-time acute diverticulitis has been reported. Our study aims to further characterize this association in COVID-19-positive patients within a large tertiary care academic center. Methodology Patients diagnosed with who subsequently developed 30 days were identified between 2020 2022. by polymerase chain...

Niacin, an important component of a balanced diet, is central to lipid metabolism. Occasionally used treat hyperlipidemia, niacin widely available without prescription, making its use often unknown treating physicians. Severe hepatotoxicity has been reported with use. In the following report, we describe case hospitalization for acute decompensated cirrhosis cholestatic morphology in patient taking self-initiated large quantities extended-release niacin. Despite medical management and...

ABSTRACT Nintedanib is a medication that has been increasingly used for treatment of idiopathic and progressive pulmonary fibrosis. In this case series, we describe 3 patients with colitis symptoms associated nintedanib use. discontinuation resulted in symptomatic resolution all patients. Budesonide decreased 1 patient. Clinicians should be vigilant taking thorough history include as cause gastrointestinal including colitis.

A male patient in his 70s with a history of tobacco use, organising pneumonia and rheumatoid arthritis that had been treated for several years rituximab currently being tocilizumab, presented progressively worsening shortness breath, increasing oxygen requirements weakness. He COVID-19 infection 6 months prior to presentation. Initial PCR testing at presentation was negative. Bronchoalveolar lavage positive but negative spike antibodies. It thought he did not clear due immunocompromised...

Pressure overload-induced left ventricular myocardial hypertrophy (LVH) regresses after pressure unloading. However, distinct structural alterations become less reversible during the progression of LVH, which might influence restoration cardiac function. Here, we investigated how a reverse remodeling process from early versus late-stage LVH affects different aspects function.Pressure overload was induced in rats for 6, 12 and 18 weeks. Sham-operated animals were used as controls. unloading...

Cancer immunotherapy has seen tremendous strides in the past 15 years, with introduction of several novel immunotherapeutic agents. Nevertheless, as clinical practice shown, significant challenges remain a considerable number patients responding sub-optimally to available therapeutic options. Research demonstrated important immunoregulatory role tumor microenvironment (TME), potential either hinder or promote an effective anti-tumor immune response. As such, scientific efforts have focused...

Lay Summary It is unknown if immune checkpoint inhibitor therapy increases risk of pouch-related complications in patients with inflammatory bowel disease after ileal-pouch anal anastomosis. In our study, pembrolizumab was not associated significant gastrointestinal immune-related adverse events or complications.

Background: The renin-angiotensin-aldosterone system (RAAS) has been associated with gastrointestinal inflammation and fibrosis, suggesting that RAAS blockade may be beneficial in patients inflammatory bowel disease. Using retrospective analysis, we aimed to compare the disease course of Crohn’s (CD) taking two commonly prescribed classes RAAS-blocking agents. Study: Patients CD initiated on an angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) between 2000...

Abstract Background Colorectal surgery in patients with inflammatory bowel disease (IBD) and cirrhosis is associated high morbidity related to portal hypertension. Thought reduce surgical risk, transjugular intrahepatic portosystemic shunt (TIPS) may be used decrease pressures. In this study, we aimed characterize outcomes of IBD who underwent preoperative TIPS at a large tertiary care center. Methods We retrospectively identified had undergone between 2010-2023 for decompression prior...

A 34-year-old man with a history of multiple episodes acute pancreatitis complicated by known pseudocysts, fatty liver disease, and polysubstance abuse presented to the emergency department sudden onset epigastric abdominal pain, nausea, vomiting. His symptoms started approximately 45 minutes after eating dinner. He was not taking any medications denied recent trauma. The patient reported active smoking (19 pack-year history) consumption several alcoholic drinks earlier that day. his pain...

Patients with inflammatory bowel disease (IBD) are at increased risk of vaccine-preventable diseases (VPDs). Despite the increasing prevalence IBD in non-white populations, little is known regarding racial disparities VPD burden.

ABSTRACT Treatment options for patients with inflammatory bowel disease are constantly evolving; however, medication-refractory remains an issue. Pediatric case series show the potential benefit of sirolimus therapy in refractory Crohn's (CD); limited data exist adult patients. As such, we retrospectively identified and report clinical outcomes 4 prescribed treatment CD. Despite a median duration 524 days some therapeutic benefits, all discontinued due to adverse effects. Our findings...

Colorectal surgery in patients with inflammatory bowel disease (IBD) and cirrhosis has increased morbidity, which may preclude surgery. Preoperative transjugular intrahepatic portosystemic shunt (TIPS) is postulated to reduce surgical risk. In this retrospective single-center study, we characterized perioperative outcomes IBD who underwent preoperative TIPS.

Background: Video capsule retention is a complication that can have serious consequences in patients with Crohn’s disease (CD). The patency was developed to detect small bowel strictures. usefulness of capsules who do not evidence on imaging uncertain. Study: This multicenter retrospective study suspected or confirmed CD underwent between January 2017 and February 2023. We excluded were lost follow-up did computerized tomography magnetic resonance the abdomen within 180 days before after...