A5062682390- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Dysphagia Assessment and Management
- Esophageal Cancer Research and Treatment
- Tracheal and airway disorders
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Pancreatitis Pathology and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Gastrointestinal Tumor Research and Treatment
- Histone Deacetylase Inhibitors Research
- Eosinophilic Disorders and Syndromes
- Organ Transplantation Techniques and Outcomes
- Alcohol Consumption and Health Effects
- Gastrointestinal Bleeding Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Mycobacterium research and diagnosis
- Gallbladder and Bile Duct Disorders
- Cancer Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Bipolar Disorder and Treatment
- COVID-19 and healthcare impacts
Mayo Clinic in Florida
2016-2025
Jacksonville College
2016-2025
WinnMed
2016-2025
Zhejiang University
2025
University of Auckland
2025
Georgetown University
2018-2020
MedStar Georgetown University Hospital
2019-2020
Mayo Clinic in Arizona
2018
Providence College
2006-2013
Roger Williams Medical Center
2013
Activation of renal interstitial fibroblasts is critically involved in the development tubulointerstitial fibrosis chronic kidney diseases. In this study, we investigated effect trichostatin A (TSA), a specific histone deacetylase (HDAC) inhibitor, on activation rat fibroblast line (NRK-49F) and murine model unilateral ureteral obstruction (UUO) . α-Smooth muscle actin (α-SMA) fibronectin, two hallmarks activation, were highly expressed cultured NRK-49F cells, their expression was inhibited...
Aspartyl-(Asparagyl)-β-hydroxylase (AAH) is overexpressed in various malignant neoplasms, including hepatocellular carcinomas (HCCs). The upstream regulation of AAH and its functional role Notch-mediated signaling motility HCC cells was accessed. mRNA transcript levels AAH, insulin receptor substrate (IRS), insulin-like growth factor (IGF) receptors polypeptides, Notch, Jagged, HES were measured 15 paired samples adjacent HCC-free human liver biopsy specimens using real-time quantitative...
Although enhanced activation of the EGF receptor (EGFR) associates with development and progression renal fibrosis, mechanisms linking these observations are not completely understood. Here, after unilateral ureteral obstruction (UUO), wild-type mice exhibited sustained EGFR phosphorylation in kidney developed fibrosis that was more severe than observed waved-2 mice, which have reduced tyrosine kinase activity. Waved-2 also showed fewer tubular cells arrested at G2/M, expression α-smooth...
The activation of cytokine and growth factor receptors associates with the development progression renal fibrosis. Suramin is a compound that inhibits interaction several cytokines factors their receptors, but whether suramin fibrosis unknown. Here, treatment cultured interstitial fibroblasts inhibited induced by TGF-β1 serum. In mouse model obstructive nephropathy, administration single dose immediately after ureteral obstruction abolished expression fibronectin, largely suppressed α-SMA...
Abstract Background and Aim Effective clinical event classification is essential for research quality improvement. The validation of artificial intelligence (AI) models like Generative Pre‐trained Transformer 4 (GPT‐4) this task comparison with conventional methods remains unexplored. Methods We evaluated the performance GPT‐4 model classifying gastrointestinal (GI) bleeding episodes from 200 medical discharge summaries compared results human review an International Classification Diseases...
Abstract Background and Aim: Chronic ethanol consumption impairs liver regeneration due, in part, to inhibition of insulin signaling. This study characterizes the mechanisms consequences ethanol‐impaired signaling relation oxidative injury altered gene expression. Methods: Long‐Evans rats were fed for 8 weeks with isocaloric liquid diets containing 0% (control) or 37% (caloric content). Livers used examine histopathology, indices stress, expression required insulin‐like growth factor (IGF)...
Multiple rapid swallows (MRS) is a provocative test during high-resolution esophageal manometry (HRM) to evaluate contraction reserve (CR). This study aims determine the prevalence of CR in patients with ineffective motility (IEM) and MRS performed upright position, assess ideal number sequences. We enrolled adult diagnosed IEM according Chicago classification version 4.0 who underwent HRM 3 Presence was identified as either: distal integral (DCI) post-MRS sequence exceeding mean DCI single...
We recently reported that the histone deacetylase (HDAC) activity is required for activation of renal interstitial fibroblasts. In this study, we further examined role HDACs, in particular, HDAC1 and HDAC2, proliferation cultured rat fibroblasts (NRK-49F) expression cell cycle proteins. Inhibition HDAC with trichostatin A (TSA), blocked proliferation, decreased Cyclin D1, a positive regulator, increased p27 p57, two negative regulators. Silencing either or HDAC2 siRNA also significantly...
Abstract Background Prolonged alcohol consumption is a significant co-factor in the progression of chronic viral infections including hepatitis C and HIV, which are both single-stranded RNA viruses. Toll like receptor 8 (TLR8), pattern recognition expressed monocytes, senses single stranded as danger signal leads to induction Type I interferon (IFN) well pro-inflammatory cytokine, tumor necrosis factor alpha (TNF alpha). Lipopolysaccharide (LPS), 4 (TLR4) ligand, was shown affect...
Aim: Chronic ethanol exposure impairs insulin signaling in the liver. Peroxisome‐proliferator activated receptor (PPAR) agonists function as sensitizers and are used to treat type 2 diabetes mellitus. We examined therapeutic effectiveness of PPAR reducing alcoholic hepatitis hepatic resistance a model chronic feeding. Methods: Adult male Long Evans rats were pair fed with isocaloric liquid diets containing 0% (control) or 37% (caloric content; 9.2% v/v) for 8 weeks. After 3 weeks on diets,...
Colorectal endoscopic submucosal dissection (ESD) has always been challenging for endoscopists, but the procedure can be facilitated after adequate exposure of layer and cutting line. We developed a traction method based on gravity facilitating colorectal ESD, referred as magnetic bead-assisted ESD (MBA-ESD). This study aimed to compare safety effectiveness MBA-ESD conventional treating large superficial tumors. retrospective included consecutive patients with (≥ 20 mm in their maximal...
Our recent studies showed that transglutaminase-1 (TGase-1) is uniquely expressed in mouse renal proximal tubular cells (RPTC) and mediates cell proliferation. In this study, we investigated the role of TGase-1 survival signaling pathways regulated by RPTC following oxidant injury. Exposure to hydrogen peroxide (H2O2) resulted apoptosis an increase TGase activity. Inhibition activity with monodansylcadervine (MDC), a inhibitor, or knockdown small interference (si)RNA enhanced decreased...
Peritubular fibroblasts in the kidney are major erythropoietin-producing cells and also contribute to renal repair following acute injury (AKI). Although few were observed interstitium adjacent damaged tubular epithelium early phase of AKI, underlying mechanism by which their numbers reduced remains unknown. In this study, we tested hypothesis that epithelial directly induce interstitial fibroblast death releasing intracellular ATP activating purinergic signaling. Exposure a cultured rat...