A5005470744- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Nanoparticle-Based Drug Delivery
- Crystallization and Solubility Studies
- RNA Interference and Gene Delivery
- Drug Transport and Resistance Mechanisms
- Lipid Membrane Structure and Behavior
- Ocular Surface and Contact Lens
- Monoclonal and Polyclonal Antibodies Research
- Transgenic Plants and Applications
- Reconstructive Surgery and Microvascular Techniques
- Hepatitis B Virus Studies
- Protein purification and stability
- Pharmacological Effects of Natural Compounds
- Advanced battery technologies research
- Traumatic Ocular and Foreign Body Injuries
- Bone Metabolism and Diseases
- Cellular transport and secretion
- Biopolymer Synthesis and Applications
- Hydrogels: synthesis, properties, applications
- Analytical Chemistry and Chromatography
- Parasitic Infections and Diagnostics
- Medical Imaging and Analysis
- Anatomy and Medical Technology
Photon Imaging (United States)
2024
Sun Yat-sen University
2021-2024
Georgia Institute of Technology
2021-2023
Shanghai Institute of Materia Medica
2013-2019
Chinese Academy of Sciences
2010-2019
Southwest Medical University
2006-2019
Affiliated Hospital of Southwest Medical University
2017
University of Copenhagen
2012-2016
Stomatology Hospital
2015
Shenyang Pharmaceutical University
2010-2013
Significance Low-cost and rapidly distributable vaccines are urgently needed to combat COVID-19 future pandemics, especially for developing countries other low-resource settings. DNA inexpensive, developed, safe, but require bulky expensive electroporation devices effective vaccination, which presents challenges affordable mass vaccination. We developed an ultra-low-cost (<1 USD), handheld (<50 g), battery-free system combining a thumb-actuated piezoelectric pulser microneedle...
Dissolvable microneedle patches (MNPs) enable simplified delivery of therapeutics via the skin. However, most dissolvable MNPs do not deliver their full drug loading to skin because only some is localized in microneedles (MNs), and rest remains adhered patch backing after removal from In this work, biphasic are developed by mounting water-soluble MNs on a water-insoluble layer. These be contained without migrating into due inability drugs partition hydrophobic materials during MNP...
Fibrotic stroma and tumor-promoting pancreatic stellate cells (PSCs), critical characters in the ductal adenocarcinoma (PDA) microenvironment, promote a tumor-facilitating environment that simultaneously prevents drug penetration into tumor foci stimulates growth. Nab-PTX, human serum albumin (HSA) nanoparticle of paclitaxel (PTX), indicates enhanced matrix PDA probably due to its small size vivo high affinity HSA with secreted protein acidic rich cysteine (SPARC), overexpressed stroma....
The aim of this study was to investigate Pluronic F127-modified liposome-containing cyclodextrin (CD) inclusion complex (FLIC) for improving the solubility, cellular uptake and intestinal penetration tacrolimus (FK 506) in gastrointestinal (GI) tract.Molecular modelling performed screen optimal CD solubilization FK 506. FLIC prepared by thin-lipid film hydration with solutions followed membrane extrusion. Dilution tests were conducted simulated gastric fluids phosphate-buffered solution...
The conversion of aqueous dispersion nanostructured lipid carriers (NLCs) into dry powder by spray drying could be a useful approach to render NLCs with better physical chemical stability than the dispersion. In this study, NLC containing fenofibrate was converted dry, easily reconstitutable using drying. A central composite face centered design (CCFD) used investigate influence ratio protectant (mannitol and trehalose) crystallinity spray-dried on particle size, yield residual moisture...
Postoperative airway, digestive tract, and chest wall fistulas are severe complications after lung resection, often associated with high mortality. Here, we reported a case of patient tracheoesophageal fistulas. After precise localization the fistula sinus tract using multimodal imaging techniques, multidisciplinary treatment team was assembled, including specialists in interventional pulmonology, gastroenterology, plastic surgery, anesthesia, pain management, to develop implement stepwise,...
Vaccination against hepatitis B using a dissolving microneedle patch (dMNP) could increase access to the birth dose by reducing expertise needed for vaccine administration, refrigerated storage, and safe disposal of biohazardous sharps waste. In this study, we developed dMNP administer surface antigen (HBsAg) adjuvant-free monovalent (AFV) at doses 5 µg, 10 20 compared its immunogenicity vaccination with µg standard HBsAg delivered intramuscular (IM) injection either in an AFV format or as...