A5069419660- Cardiac Imaging and Diagnostics
- Cardiac Ischemia and Reperfusion
- Nitric Oxide and Endothelin Effects
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Transplantation: Methods and Outcomes
- Cardiovascular Effects of Exercise
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Organ Transplantation Techniques and Outcomes
- Complement system in diseases
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac Valve Diseases and Treatments
- Phosphodiesterase function and regulation
- Protease and Inhibitor Mechanisms
- Cardiovascular Health and Disease Prevention
- Pulmonary Hypertension Research and Treatments
- Cardiovascular and exercise physiology
- Eicosanoids and Hypertension Pharmacology
- Coronary Interventions and Diagnostics
- Renin-Angiotensin System Studies
- Menopause: Health Impacts and Treatments
Semmelweis University
2008-2024
Heidelberg University
2011-2021
University Hospital Heidelberg
2009-2021
Beth Israel Deaconess Medical Center
2016
Jefferson College
2016
German Cancer Research Center
2016
Deutschen Konsortium für Translationale Krebsforschung
2016
Boston Children's Hospital
2016
Massachusetts General Hospital
2016
German Centre for Cardiovascular Research
2016
Background— The role of the nitric oxide/cGMP/cGMP–dependent protein kinase G pathway in myocardial protection and preconditioning has been object intensive investigations. novel soluble guanylate cyclase activator cinaciguat reported to elevate intracellular [cGMP] activate vivo. We investigated effects on infarction induced by isoproterenol rats. Methods Results— Rats were treated orally twice a day for 4 days with vehicle or (10 mg/kg). Isoproterenol (85 mg/kg) was injected subcutaneously...
Background: Reports about the generation of 3-dimensional neoscaffolds for myocardial tissue engineering are limited. The architecture provided by perfusion decellularization whole hearts would support production human-sized living tissues from an acellular matrix. aim this study was to evaluate potential a model heart engineering. Methods and Results: Hearts were obtained 12 German Landrace pigs selected abattoir. After preparation, mounted perfused on modified Langendorff specifically...
To investigate the cardiovascular consequences of SARS-CoV-2 infection in highly trained, otherwise healthy athletes using cardiac magnetic resonance (CMR) imaging and to compare our results with sex-matched age-matched less active controls.
A number of data indicate that the lectin pathway complement activation contributes to pathophysiology ischemic stroke. The may be triggered by binding mannose-binding (MBL), ficolin-2 or ficolin-3 different ligands. Although several papers demonstrated significance MBL in stroke, role ficolins has not been examined. Sera were obtained within 12 hours after onset stroke (admission samples) and 3-4 days later (follow-up from 65 patients. control group comprised 100 healthy individuals 135...
Increasing evidence suggests that both types of diabetes mellitus (DM) lead to cardiac structural and functional changes. In this study we investigated compared characteristics underlying subcellular pathological features in rat models type-1 type-2 diabetic cardiomyopathy. Type-1 DM was induced by streptozotocin. For DM, Zucker Diabetic Fatty (ZDF) rats were used. Left ventricular pressure-volume analysis performed assess function. Myocardial nitrotyrosine immunohistochemistry, TUNEL assay,...
S100A6, a member of the S100 protein family, has been described as relevant for cell cycle entry and progression in endothelial cells. The molecular mechanism conferring S100A6's proliferative actions, however, remained elusive.Originating from clinically observation enhanced S100A6 expression proliferating cells remodeling coronary carotid arteries, our study unveiled suppressor antiproliferative signal transducers activators transcription 1 signaling. Discovery liaison was enabled by...
Oxidative stress interferes with nitric oxide (NO)/soluble guanylate cyclase (sGC)/cyclic guanosine monophosphate (cGMP) signalling pathway through reduction of endogenous NO and formation the strong intermediate oxidant peroxynitrite leads to vascular dysfunction. We evaluated effects oral treatment NO- heme-independent sGC activator cinaciguat on peroxynitrite-induced dysfunction in rat aorta. Sprague-Dawley rats were treated orally 2 times at an interval 17 hours vehicle or (10 mg/kg)....
Background Many donor organs come from youths involved in alcohol-related accidental death. The use of cardiac allografts for transplantation donors after acute poisoning is still under discussion while ethanol intoxication associated with myocardial functional and morphological changes. aims this work were 1) to evaluate rats the time-course effects ethanol-exposure 2) explore how its abuse by might affect recipients pump function transplantation. Methods Rats received saline or (3.45 g/kg,...
Recently, the infarct reducing and cardioprotective effects of phosphodiesterase-5-inhibitors were described. In this study, we investigated these on ischemia/reperfusion injury in a rat model heart transplantation. Three groups assigned for our study: vardenafil preconditioning group, an ischemic control, nonischemic control. Hemodynamic parameters significantly increased group (Pmax: 82+/-4 vs. 110+/-12 127+/-13 mm Hg; dP/dtmax: 1740+/-116 3197+/-599 4397+/-602 Hg/sec; control control;...
Background . In-stent restenosis (ISR) is the gradual narrowing of vessel lumen after coronary stent implantation due to increase in vascular smooth muscle cell proliferation. Vascular endothelial growth factor (VEGF) protein plays an important role this process. Our aim was analyze association single nucleotide polymorphisms VEGF gene (rs2010963 and rs6999447) with occurrence ISR artery bare metal (BMS) implantation. Methods 205 patients a history BMS repeated coronarography were...
The pathophysiology of ischemic myocardial injury involves cellular events, reactive oxygen species, and an inflammatory reaction cascade. zinc complex acetylsalicylic acid (Zn(ASA) 2 ) has been found to possess higher anti-inflammatory lower ulcerogenic activities than (ASA). Herein, we studied the effects both ASA Zn(ASA) against acute ischemia. Rats were pretreated with (75 mg/kg) or (100 orally for five consecutive days. Isoproterenol (85 mg/kg, subcutaneously [s.c.]) was applied produce...
Background: Reperfusion of ischemic myocardium may contribute to substantial cardiac tissue damage, but the addition iron chelators, zinc or complexes has been shown prevent heart from reperfusion injury. We investigated possible beneficial effects an iron-chelating and zinc-complexing agent, Q50, in rat models ischemia/reperfusion (I/R)-induced myocardial infarction on global reversible I/R injury after transplantation. Methods Results: Rats underwent 45-min ischemia by left anterior...