A5007515183- Cardiac Ischemia and Reperfusion
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Anesthesia and Neurotoxicity Research
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrest and Resuscitation
- Antioxidant Activity and Oxidative Stress
- Protease and Inhibitor Mechanisms
- Extracellular vesicles in disease
- Mechanical Circulatory Support Devices
- Peptidase Inhibition and Analysis
- Cardiac Fibrosis and Remodeling
- Ion Transport and Channel Regulation
- Signaling Pathways in Disease
- Cell death mechanisms and regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Electron Spin Resonance Studies
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Trace Elements in Health
- Stress Responses and Cortisol
- Biochemical effects in animals
- Ion channel regulation and function
- Chemotherapy-induced cardiotoxicity and mitigation
Slovak Academy of Sciences
2016-2025
Centre of Experimental Medicine of the Slovak Academy of Sciences
2018-2025
Comenius University Bratislava
2015-2024
Czech Academy of Sciences, Institute of Physiology
2015-2023
Institute of Experimental Endocrinology of the Slovak Academy of Sciences
2010
Although incidence and prevalence of prediabetes are increasing, little is known about its cardiac effects. Therefore, our aim was to investigate the effect on function characterize parameters pathways associated with deteriorated performance. Long-Evans rats were fed either control or high-fat chow for 21 wk treated a single low dose (20 mg/kg) streptozotocin at week 4 High-fat treatment induced as characterized by slightly elevated fasting blood glucose, impaired glucose insulin tolerance,...
Quercetin (QCT) is flavonoid that possesses various biological functions including anti-oxidative and radical-scavenging activities. Moreover, QCT exerts some preventive actions in treatment of cardiovascular diseases. The aim present study was to explore effects prolonged administration on changes induced by repeated application doxorubicin (DOX) rat hearts. We focused the ultrastructure myocardium, matrix metalloproteinases (MMPs), biometric parameters, apoptosis induction. Our also...
Quercetin, a polyphenolic compound present in various types of food, has been shown to exert beneficial effects different cardiac as well non-cardiac ischemia/reperfusion (I/R) models adult animals. However, there is no evidence about the quercetin on I/R injury non-mature animals, despite fact that efficiency some interventions against age-dependent. This study was aimed investigate chronic treatment juvenile and rat hearts. Juvenile (4-week-old) (12-week-old) rats were treated with (20...
Background: Quercetin (QCT) was shown to exert beneficial cardiovascular effects in young healthy animals. The aim of the present study determine benefits QCT older, 6-month and 1-year-old Zucker diabetic fatty (ZDF) rats (model type 2 diabetes). Methods: Lean (fa/+) obese (fa/fa) ZDF both ages were treated with for 6 weeks (20 mg/kg/day). Isolated hearts exposed ischemia-reperfusion (I/R) injury (30 min/2 h). Endothelium-dependent vascular relaxation measured isolated aortas. Expression...
Abstract Despite significant advances in the diagnosis and treatment of cardiovascular diseases, recent calls have emphasized unmet need to improve precision-based approaches disease. Although some studies provide preliminary evidence diagnostic prognostic potential circulating coding non-coding RNAs, complex RNA biology lack standardization hampered translation these markers into clinical practice. In this position paper CardioRNA COST action CA17129, we recommendations standardize...
Quercetin is a plant-derived bioflavonoid with potentially beneficial effects on the cardiovascular system. Studies focused efficiency of flavonoids against ischemia–reperfusion (I/R) injury have demonstrated that quercetin exerts robust protective in renal, cerebral, and hepatic I/R models. However, there only limited evidence about effect myocardial injury. Therefore, aim current study was to examine isolated rat heart during ischemia reperfusion. Rat hearts perfused according Langendorff...
Oxytocin is a hormone, which released into the circulation in response to acute or chronic stress stimuli.One of important targets oxytocin cardiovascular system.Present studies were aimed at testing hypothesis that prolonged treatment with (simulation stress-induced rise circulating oxytocin) activates intracellular signaling pathways playing role ischemia/reperfusion injury.Furthermore, we tested protective effects vivo against cardiac injury induced by isolated hearts.Male Wistar rats...