A5058115874- Reproductive System and Pregnancy
- Sperm and Testicular Function
- Epigenetics and DNA Methylation
- Renal and related cancers
- Phytochemicals and Medicinal Plants
- Prenatal Screening and Diagnostics
- Metabolism and Genetic Disorders
- Per- and polyfluoroalkyl substances research
- Advanced Glycation End Products research
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Peroxisome Proliferator-Activated Receptors
- Effects and risks of endocrine disrupting chemicals
- Traumatic Ocular and Foreign Body Injuries
- Ocular Diseases and Behçet’s Syndrome
- Myasthenia Gravis and Thymoma
- Endoplasmic Reticulum Stress and Disease
- ATP Synthase and ATPases Research
- Autophagy in Disease and Therapy
- Reproductive Health and Contraception
- Advanced Fluorescence Microscopy Techniques
- Caveolin-1 and cellular processes
- Sarcoidosis and Beryllium Toxicity Research
- Liver physiology and pathology
- Nitric Oxide and Endothelin Effects
Huazhong University of Science and Technology
2020-2024
Guiyang Medical University
2024
Nanjing University of Chinese Medicine
2019
Chung Shan Medical University
2003-2005
Abstract Catalpol (Cat.) is an iridoid glucoside extracted from the root of Rehmannia glutinosa Libosch . In this study, we investigated whether Cat. could protect mouse glomerular endothelial cells against deleterious effect induced by advanced glycation end products (AGEs) and explored potential mechanisms. We found that 10 μM showed a protective on dead stimulated AGEs. significantly decreased expression p‐NF‐κBp65 inducible nitric oxide synthase (iNOS) increased...
Abstract Sperm DNA injury is one of the common causes male infertility. Folic acid deficiency would increase methylation level important genes, including those involved in double‐strand break (DSB) repair pathway. In early stages, we analysed correlation between seminal plasma folic concentration and semen parameters 157 infertility patients 91 sperm donor volunteers, found that there was a significant negative Fragmentation Index (DFI; r = −0.495, p < 0.01). Then through reduced...
Zishen Yutai Pill (ZYP), containing 15 Chinese traditional medicine, is a safe and well quality-controlled TCM preparation with promising effects in many fields of reproduction. The current study was designed to investigate the therapeutic ZYP on sperm quality testis varicocele (VC) rats.Male Wistar rats were randomly divided into four groups (n = 6), i.e., sham group, VC treated different dose (1575 3150 mg/kg/d, respectively). experimental model established by partial ligation left renal...
Leber's hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease that primarily affects the nerve, causing bilateral vision loss in juveniles and young adults. A 12‐year‐old boy had complained of blurred both eyes for more than 1 year. His best‐corrected visual acuity was 0.08 right eye 0.1 left. Ophthalmologic examination showed disc hyperemia margin blurring, peripapillary telangiectasis, relative afferent pupil defect his eye. Fluorescein angiography no stain or...
Male reproductive infections are known to shape the immunological homeostasis of testes, leading male infertility. However, specific pathogenesis these changes remains poorly understood. Exosomes released in inflammatory microenvironment important communication between local and recipient cells. Here, we aim identify immunomodulatory properties testes-derived exosomes (IT-exos) explore their underlying mechanisms orchitis. IT-exos were isolated using a uropathogenic Escherichia coli...
Liver fibrosis is the initial pathological process of many chronic liver diseases. Targeting hepatic stellate cell (HSC) activation an available strategy for therapy fibrosis. We aimed to explore anti-liver activity and potential mechanism phomopsterone B (PB) in human HSCs. The results showed that PB effectively attenuated proliferation TGF-β1-stimulated LX-2 cells a concentration-dependent manner at doses 1, 2, 4 μM. Quantitative real-time PCR Western blot assays displayed significantly...
Two new withanolides named physaminilides L (1) and M (2), together with four known ones (3–6) were isolated from the Physalis minima L. The structures established by analysis of HR ESIMS, IR NMR spectroscopic data. absolute configurations determined through NOESY ECD spectra. For compounds 1–5 assayed at 20 µM compound 6 10 µM, inhibition rates hepatic fibrosis 22.19%, 15.29%, 37.07%, 9.27%, 12.45%, 37.03%, respectively.
Folic acid is critical to maintaining normal male reproductive function. Endoplasmic reticulum (ER) stress plays a crucial role in folic deficiency. Studies have shown that Caveolin-1 (Cav-1) involved ER stress, but the specific mechanism reproduction still unclear. This study aimed investigate effects of deficiency on spermatogenesis and elucidate underlying mechanisms. C57BL/6 mice fed with induced diet(0.3 mg/kg) were used. A significant decrease sperm concentration group was observed....
Purpose: To report a case of ocular myasthenia gravis worsened by topical β-Blocker Method: A Result: 73 year-old man who had regular used β-blocker to treat his glaucoma for 5 years visited our hospital ptosis and binocular diplopia. Ocular was diagnosed. He treated with thymectomy oral medication prednisolone pyridostigmine, but without significant improvement. His symptoms were relieved soon after the switch timolol latanoprost. Conclusion: Usage β-blockers in patients should be monitored...
Laser subepithelial keratomileusis(LASEK) is a surgical technique that combines features of photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK). LASEK an effective safe procedure for myopia with LADAR Vision 4000.
Background: Sperm DNA injury is one of the common causes male infertility. Folic acid deficiency would increase methylation level important genes, including double-strand Break(DSB) repair pathway. This study aims to preliminarily investigate underlying mechanism on how abnormal caused by folic aggravates sperm damage.Methods: Through reduced representation bisulfite sequencing(RRBS), Global patients in low group and high was analyzed, differential genes were selected. Animal models cell...
Abstract background : In recent years, contraceptives have developed rapidly, which are divided into modern and non-modern contraceptives. The use of less unwanted pregnancy sexually transmitted infections(STIs) including HIV. And cause traditional attitudes towards sex, marriage family changed. It leads to a lack caution about sex pre-marital is more acceptable. Hence, the number miscarriages caused by pregnancies has increased. People going settle many sexual reproductive health matters....
Objective: To investigate the effects of ZYP on sperm parameters, DNA integrity, and chronic testicular inflammation in experimental varicocele (VC) rats.Materials methods: Twenty-four male Wistar rats were randomly divided into four groups (n=6), i.e., a sham group, VC treated with different dose (1575 3150 mg/kg/d, respectively). The model was established by partial ligation left renal vein. Six weeks after establishment, orally administered once day for next 6 weeks. Parameters relating...