A5101482952- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Venous Thromboembolism Diagnosis and Management
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- Drug-Induced Hepatotoxicity and Protection
- Cancer Mechanisms and Therapy
- Lipid metabolism and disorders
- Electrocatalysts for Energy Conversion
- Genetic factors in colorectal cancer
- interferon and immune responses
- Kruppel-like factors research
- Fuel Cells and Related Materials
- Cancer, Lipids, and Metabolism
- Bone Metabolism and Diseases
- NF-κB Signaling Pathways
- Mycobacterium research and diagnosis
- Advanced battery technologies research
- Cytokine Signaling Pathways and Interactions
- Adenosine and Purinergic Signaling
- RNA Interference and Gene Delivery
- Molecular Biology Techniques and Applications
- Fatty Acid Research and Health
Nanchang University
2021-2024
Tianjin Hospital
2017-2022
Xiangya Hospital Central South University
2018-2021
Central South University
2018-2021
Second Affiliated Hospital of Nanchang University
2021
China Tobacco
2020
Xinjiang Medical University
2016-2020
Yuhuangding Hospital
2019-2020
First Affiliated Hospital of Xinjiang Medical University
2020
Qingdao University
2020
Noncoding RNAs are emerging as important players in gene regulation and disease pathogeneses. Here, we show that a previously uncharacterized long noncoding RNA, nexilin F-actin binding protein antisense RNA 1 (NEXN-AS1), modulates the expression of actin-binding NEXN exerts protective role against atherosclerosis. An microarray analysis showed both NEXN-AS1 was reduced human atherosclerotic plaques. In vitro experiments revealed interacted with chromatin remodeler BAZ1A 5' flanking region...
MicroRNAs (miRNAs) are small noncoding RNAs that involved in different biological processes by suppressing target gene expression. miRNA microarray analysis revealed a significant decrease of miR-26a prostate cancer tissues versus their normal counterparts, but the role is needed to investigate. In present study, we found expression was lower compared with controls, so did cells. Next, lentivirus-mediated gain-of-function studies, it showed stable inhibited cell proliferation, metastasis,...
// Lihui Wang 1, 2 , Yanli He 2, 3 Weijun Liu 4 Shengbin Bai 5 Lei Xiao Jie Zhang 6 Saravana M. Dhanasekaran 7 Zhuwen Shanker Kalyana-Sundaram O. Alejandro Balbin Sudhanshu Shukla Yi Lu 1 Jules Lin Rishindra Reddy Philip W. Carrott Jr William R. Lynch Andrew C. Chang Arul Chinnaiyan David G. Beer Jian Guoan Chen Guangxi Medical University, Nanning, China Section of Thoracic Surgery, Department University Michigan, Ann Arbor, United States America Guangzhou Chinese Medicine, Guangzhou, The...
Abstract Background Osteosarcoma is one of the most prevalent primary bone tumours in adolescents. Accumulating evidence shows that aberrant expression long non-coding RNA (lncRNA) NEAT1 and microRNA-483 (miR-483) contribute to epithelial-mesenchymal transition (EMT), invasion metastasis tumour cells. However, potential regulatory effects miR-483 on EMT osteosarcoma remain elusive. Methods The NEAT1, miR-483, signal transducer activator transcription-1 (STAT1), STAT3, EMT-associated markers...
Abstract Whole transcriptome analyses of next generation RNA sequencing (RNA-Seq) data from human cancer samples reveled thousands uncharacterized non-coding RNAs including long (lncRNA). Recent studies indicated that lncRNAs are emerging as crucial regulators in processes and potentially useful biomarkers for diagnosis prognosis. To delineate dysregulated lung cancer, we analyzed RNA-Seq 461 adenocarcinomas (LUAD) 156 normal tissues. FAM83H-AS1 , one the top lncRNAs, was found to be...
Through bioinformatics analysis, a novel lncRNA, LINC00460, was implicated in the development of multiple cancers.However, precise expression pattern, clinical significance and biological function LINC00460 colorectal cancer (CRC) remain unknown.Network databases were used to investigate correlation between CRC.In situ hybridization performed verify pattern CRC tissue microarray, which included 92 pairs adjacent normal tissues.The effect on proliferation evaluated by MTT, colony formation...
Abnormally expressed microRNAs (miRNAs) contribute widely to human cancer, including oral squamous cell carcinoma (OSCC), by regulating their downstream targets. MiR-223 has been proved be up-regulated in both gastric cancer and ovarian cancer. However, the effect of miR-223 on OSCC is still unclear. Here, we showed that was over-expressed tissues using qRT-PCR. Next, investigated biological mechanism OSCC. The results demonstrated facilitated proliferation migration MTT assay Transwell...
We employed RNA sequencing analysis to reveal dysregulated lncRNAs in lung cancer utilizing 461 adenocarcinomas and 156 normal tissues from 3 separate cohorts. found that LINC00152 was highly overexpressed tumors as compared their adjacent tissues. Patients with high expression demonstrate a significantly poorer survival than those low expression. verified the diagnostic/prognostic potential of an independent cohort tumor using quantitative RT-PCR. After knockdown siRNAs cell lines, both...
Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of oral cavity. Emerging evidence indicates that long non‑coding (lnc)RNAs play a key role in cellular processes cells, including glycolysis, growth and movement. Here, purpose this study was to explore biological functions potential mechanism lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) OSCC. OSCC tissues adjacent matched paraneoplastic normal were collected from 20 patients. The expression...
Exploring catalysts with low cost and excellent performance for hydrogen evolution reaction (HER) is still a significant challenge. In this work, zeolitic imidazolate framework-8 (ZIF-8), hybridizing polyvinylpyrrolidone, was used to prepare Zn, Ni co-loaded N doped porous carbon (ZnNi/NPC) via facile absorption pyrolysis process. The as-prepared ZnNi/NPC as catalyst (HER). This experiments show that the structure doping have great influence on HER activity of catalyst. Comparing Zn/NC...
Background and Purpose The calcium antagonist amlodipine exerts important cardioprotective effects by modulating smooth muscle endothelial functions. However, the mechanisms underlying these are incompletely understood. Experimental Approach Western blotting was used to compare expression of key genes involved in vascular cell (VSMC) phenotype conversion. Recombinant adeno‐associated virus system regulate miRNA rats via tail vein. Bioinformatics predict transcriptional regulation miR‐21...
High-throughput RNA-sequencing studies of tumor samples have identified a large number long non-coding RNAs (lncRNAs) which are associated with various types cancer. LncRNAs play key roles in regulating chromatin dynamics, gene expression, growth, differentiation and development. However, the role LOC389641 non-small cell lung cancer (NSCLC) tumorigenesis is not clear. Here, we investigated expression pattern, mechanism expressions tissues lines were measured by qRT-PCR. Functional including...
Invasion and metastasis are major contributors to treatment failure in patients with head neck squamous cell carcinomas (HNSCCs) microRNAs (miRNAs) reported play important roles tumor progression.Our study therefore try find the crucial miRNAs reveal their molecular functional mechanisms involved migration invasion of HNSCCs.Through The Cancer Genome Atlas (TCGA) data analysis, we screened out miR-3187-3p its biological function specific mechanism were further analyzed.The wound-healing...
Increasing evidence suggests that long non-coding RNAs (lncRNAs) are crucial in cancer biological processes. To investigate if lncRNA contributes to gastric (GC), we conducted a bioinformatics analysis human microarray datasets, and the results showed prostate cancer-associated transcript 19 (PCAT19) was upregulated GC. Quantitative reverse-transcriptase PCR situ hybridization assays also revealed PCAT19 GC tissues. The expression significantly related tumor size, lymph node metastasis,...
To explore the risk factors for inferior vena cava filter (IVCF) thrombus in orthopedic trauma patients who underwent placement with ongoing anticoagulation clinical settings.
Abstract Transforming growth factor‐β1 (TGF‐β1) is one of critical cytokines in radiation‐induced liver injury. Hepatic stellate cells (HSC) are activated the early stage However, it currently unclear whether phosphatidylinositol 3‐kinase (PI3K/Akt) signal pathway Herein, male Sprague‐Dawley rats were irradiated with 6 MV X‐rays (30 Gy) on right liver. Next, Hematoxylin and eosin staining, Masson electron microscopy performed to examine pathological changes. Immunohistochemistry was assess...
Objective To explore the relation between lower extremity deep venous thrombosis and knee injury. Methods 100 injury patients were operated on in our department. The difference of incidence rates DVT, thrombus location DVT before after operation two groups was compared. There no fatal pulmonary embolism occurring either group. Results The rate tibial plateau fracture group 52%, that patellar 30% (P 0.05). Conclusions There is a high joint injury. Which closely related to...