A5053453682- Fatty Acid Research and Health
- Circular RNAs in diseases
- Renin-Angiotensin System Studies
- Cancer Research and Treatments
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Blood Pressure and Hypertension Studies
- Nutritional Studies and Diet
- Chronic Kidney Disease and Diabetes
- MicroRNA in disease regulation
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Kidney Injury Research
- Hormonal Regulation and Hypertension
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cardiac Arrhythmias and Treatments
- Renal and Vascular Pathologies
- Heart Rate Variability and Autonomic Control
- Natural Antidiabetic Agents Studies
- Advanced Glycation End Products research
- RNA modifications and cancer
- Eicosanoids and Hypertension Pharmacology
First Affiliated Hospital of Fujian Medical University
2009-2025
Fujian Medical University
2009-2025
Second Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2025
Kingmed Diagnostics
2025
CCS Associates (United States)
2022
Cornell University
2020-2022
Capital Medical University
2022
Tianjin Medical University General Hospital
2022
Beijing Anzhen Hospital
2022
Purpose The accuracy of the Omron J760 electronic blood pressure (BP) monitor for upper arm BP measurement in adult general population was validated following AAMI/ESH/ISO (ISO 81060-2:2018) + Amd1:2020 protocol. We expect that this device can be used home monitoring, with its measurements serving as a clinical reference.
Severe cases of COVID-19 are characterized by an excessive presence neutrophils. Neutrophil extracellular traps (NETs), released activated neutrophils due to SARS-CoV-2 infection, contribute lung epithelial cell death and key drivers in COVID-19-associated immunothrombosis. However, the mechanism underlying NET formation remain unclear. Extracellular vesicles (EVs) were isolated from serum patients healthy volunteers, while blood samples volunteers. Neutrophils treated with EVs, NETs was...
Abstract Klebsiella pneumoniae (KP), recognized for its pronounced antibiotic resistance, is a prevalent agent of nosocomial infections such as hospital‐acquired pneumonia. The alarming rate serious and associated mortality renders KP significant public health threat. Extracellular vesicles (EVs) are pivotal in KP's physiological pathological mechanisms, facilitating material information transfer mediating interactions between the bacteria host. critical role EVs enhances our understanding...
<title>Abstract</title> Hypertension is often associated with elevated nighttime blood pressure (BP), a significant risk factor for cardiovascular and cerebrovascular diseases. This study explores the effects of renal denervation (RDN) on circadian BP rhythms clock gene expression in spontaneously hypertensive rats (SHR). Ten-week-old SHR were randomized into RDN sham surgery (Sham) groups, Wistar-Kyoto (WKY) as controls. was measured at rest (14:00) during activity (02:00) biweekly,...
Abstract Aims/hypothesis In type 2 diabetes mellitus (T2DM), the abnormal protein and lipid composition of diabetic high‐density lipoprotein (HDL) could impair its anti‐inflammatory functions. Whether nonenzymatic glycation directly impaired effects HDL in innate immunity remained unclear. Methods Human acute monocytic leukemia cell line (THP‐1) cells, mouse RAW 264.7 macrophages primary human monocytes derived were pre‐incubated with native HDL, isolated from T2DM patients or glycated...
Fatty acid composition in plasma captures both dietary intake and endogenous synthesis. Prospective analyses of fatty are needed to establish the role monounsaturated acids (MUFAs) polyunsaturated (PUFAs) on risk developing colorectal cancer. To evaluate associations between colon or rectal cancer separately, a nested case-control study 350 (211 139 rectal) cases an equal number individually matched control subjects was conducted within Singapore Chinese Health Study, cohort 63,257 men women...
We aimed to examine the prospective association between plasma FAs, oxylipins, and risk of acute myocardial infarction (AMI) in a Singapore Chinese population. A nested case-control study with 744 incident AMI cases matched controls aged 47–83 years was conducted within Health Study. Nineteen FAs 12 oxylipins were quantified using MS. These grouped into FA clusters 5 oxylipin hierarchical clustering, their associations assessed. Long-chain n-3 [odds ratio (OR) = 0.67 per SD increase, 95%...
Many viruses inhibit or retard apoptosis, a strategy that subverts one of the most ancient antiviral mechanisms. M11L, myxoma virus-encoded antiapoptotic protein, has been previously shown to localize mitochondria and block apoptosis virus-infected cells (H. Everett, M. Barry, S. F. Lee, X. J. Sun, K. Graham, Stone, R. C. Bleackley, G. McFadden, Exp. Med. 191:1487-1498, 2000; H. Frantz, L. Berthiaume, 196:1127-1139, 2002; Wang, W. Barrett, Nazarian, Gao, Colwill, Moran, Virol. 78:7097-7111,...
High arachidonic acid (AA; 20:4 n - 6) status may have adverse effects on inflammation and risk of cardiovascular diseases. Concerns about high intake 6 polyunsaturated fatty acids (PUFAs) are based the premise that endogenous conversion from linoleic (LA; 18:2 is an important source AA, but few population-based studies investigated dietary determinants AA status. In this study, we examined habitual food consumption in relation to plasma concentrations other PUFAs studies. We used...
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Two distinct subtypes of angiotensin (Ang) II receptors, type 1 (AT ) and 2 ), have been identified. Vascular smooth muscle cells (VSMCs) usually express AT receptor. To elucidate the direct effects receptor on in VSMCs, we transfected gene into cultured rat VSMCs. Overexpression significantly decreased expression 1a at both mRNA protein levels presence absence Ang increased bradykinin inducible NO Bradykinin B antagonist HOE–140 synthase inhibitor N ω -nitro- l -arginine methyl ester...
We examined the relationship between different patterns of meat and seafood consumption plasma metabolic profiles in an Asian population. selected 270 ethnic Chinese men women from Singapore Prospective Study Program based on their dietary habits assessed with a validated food frequency questionnaire. Participants were divided into four subgroups: high (n = 60), low 64), 86) consumers. Plasma metabolites measured using both targeted untargeted mass spectroscopy-based analyses. A total 42...
Abstract Mounting evidence showed that microRNAs involve in development and chemoresistance of various human cancers. We explored the roles mechanisms miR‐144 resistance to cisplatin (CDDP) cervical cancer cells. LIM homeobox 2 (LHX2) expression CDDP‐resistant parental cells was determined by quantitative real‐time polymerase chain reaction (qRT‐PCR) Western blot analysis, respectively. The functions overexpression on cell viability, incidence apoptosis, activity caspase‐3/7,...
Abstract BACKGROUND The effectiveness of renal denervation (RDN) in reducing blood pressure and systemic sympathetic activity hypertensive patients has been established. However, the underlying central mechanism remains unknown. This study aimed to investigate role RDN regulating cardiovascular function via renin–angiotensin system (RAS) pathway. METHODS Ten-week-old spontaneously rats (SHR) were subjected selective afferent (ADN) using capsaicin solution. We hypothesized that ADN would...
Increasing evidence has indicated that aberrant expression of miRNAs been shown to be strongly implicated in the initiation and progression glioblastoma. Here, we identified a novel tumor suppressive miRNA, miR-564, investigated its role therapeutic effect for We showed miR-564 was down-regulated human glioblastoma tissues cell lines. Introduction dramatically inhibited growth invasion cells. Subsequent experiments revealed Transforming factor-β1 (TGF-β1) direct functional target...
Introduction: MiR143HG is a recently identified tumor suppressor in bladder cancer. We performed bioinformatics prediction and found that miR143HG can form base pairs with miR-125a. This study was therefore carried out to explore the interaction between miR-125a endometrial carcinoma (EC). Methods: Gene expression analyzed by qPCR Western blot. Interactions among genes were over-expression experiments. Cell apoptosis after transfections cell assay. Results: down-regulation of EC predicted...