A5013466558- Veterinary Equine Medical Research
- Veterinary Pharmacology and Anesthesia
- Anesthesia and Pain Management
- Nail Diseases and Treatments
- Infectious Diseases and Mycology
- Fungal Infections and Studies
- Organ Transplantation Techniques and Outcomes
- Musculoskeletal synovial abnormalities and treatments
- Osteoarthritis Treatment and Mechanisms
- Bacterial biofilms and quorum sensing
- Tendon Structure and Treatment
- Bone Tissue Engineering Materials
- Cleft Lip and Palate Research
- IL-33, ST2, and ILC Pathways
- Sports injuries and prevention
- Autoimmune Bullous Skin Diseases
- Nanopore and Nanochannel Transport Studies
- Voice and Speech Disorders
- Cardiac Ischemia and Reperfusion
- Shoulder Injury and Treatment
- Proteoglycans and glycosaminoglycans research
- 3D Printing in Biomedical Research
- Anesthesia and Neurotoxicity Research
- Microfluidic and Bio-sensing Technologies
- Cellular Mechanics and Interactions
University of Pennsylvania
2018-2025
Cornell University
2020-2024
New York State College of Veterinary Medicine
2021-2024
California University of Pennsylvania
2023
Mayo Clinic in Florida
2016
Summary This report describes the placement of custom‐designed intraluminal self‐expanding nitinol stents spanning entire length trachea for treatment tracheal collapse in two Miniature Horses. Both horses underwent an initial anaesthetic event and diameter measurements performed fluoroscopically at inspiratory pressures 20 30 cm H 2 O. Once were available, a second was fluoroscopic guided stents. The first case found dead 36 days after stent placement; necropsy showed proliferative,...
Summary This randomised, double‐blind, placebo‐controlled study compared the effect of perineural with intravenous dexamethasone, both administered concomitantly interscalene brachial plexus block for shoulder surgery. Patients received 8 mg dexamethasone mixed ropivacaine in injection (n = 42), intravenously at time 37), or saline 41) block. Perineural and resulted prolonged mean ( SD ) duration to 16.9 (5.2) h 18.2 (6.4) h, respectively, 13.8 (3.8) (p 0.001). Mean (SD) opioid consumption...
The glycosaminoglycan hyaluronan (HA) plays important roles in diverse physiological functions where the distribution of its molecular weight (MW) can influence behavior and is known to change response disease conditions. During inflammation, HA undergoes a covalent modification which heavy chain subunits inter-alpha-inhibitor family proteins are transferred structure, forming chain-HA (HC•HA) complexes. While limited assessments HC•HA have been performed previously, determining size...
Inflammation of the synovium, known as synovitis, plays an important role in pathogenesis osteoarthritis (OA). Synovitis involves release a wide variety pro-inflammatory mediators synovial fluid (SF) that damage articular cartilage extracellular matrix and induce death apoptosis chondrocytes. The composition is dramatically altered by inflammation OA, with changes to both hyaluronic acid lubricin, primary lubricating molecules SF. However, relationship between key biochemical markers joint...
Cells feel the tension of implanted and injected silicone materials.
Lameness is a debilitating condition in equine athletes that leads to more performance limitation and loss of use than any other medical condition. There are limited number non-terminal experimental models can be used study early inflammatory synovial fluid biophysical changes occur the joint. Here, we compare well-established carpal IL-1β-induced synovitis model tarsal intra-articular lavage model, focusing on serial cytokines/chemokines lubricating molecules lubricin/proteoglycan 4...
Guttural pouch mycosis (GPM) is a cause of nasal discharge, dysphagia and fatal haemorrhage in the horse.To report complications success salpingopharyngeal fistulation horses with GPM. We hypothesised that creating direct static opening into guttural from pharynx would regression fungal plaques due to change environment this treatment result resolution infection prior secondary complications.Retrospective case series.The medical records all diagnosed GPM were presented New Bolton Center...
To evaluate the efficacy of 2 different oxygen delivery strategies-intranasal and tracheal insufflation-on inspired fraction (FIO2) in standing horses to determine time needed for arterial partial pressure (PaO2) equilibration.6 healthy adult horses.In this blinded, randomized crossover design study, were randomly assigned receive via nasal cannula (group N) or transcutaneous catheter T). After placement venous catheters, FIO2 was measured through a placed into distal portion trachea....
Large colon volvulus is a cause of colic in horses with high morbidity and mortality when not promptly treated. More treatment options are needed to improve the outcome these cases by protecting against damage caused ischaemia reperfusion injury.
Abstract Non-antibiotic treatment options are needed to combat biofilm formation in clinical settings, and cold plasma, an energized gas containing a cocktail of reactive oxygen nitrogen species, may be such strategy. In vitro, plasma is antimicrobial through direct bacterial killing modulation virulence factors. Cold also immunostimulatory by enhancement innate immune effector responses. We evaluated the efficacy for treating periprosthetic infection vivo rat model. Infection mitigation...
Abstract Staphylococcal aureus (S. aureus) resides in biofilms and produces virulence factors. Cold atmospheric plasma treatment can be used to kill reduce bacteria expression. This study will observe the effects of cold on S. killing, biofilm disruption, factor, quorum sensing gene expression vitro vivo. were grown discs then treated with (J-Plasma; Apyx Medical Inc.) CFU counts, Crystal Violet Staining, SEM conducted determine disruption killing. Gene was determined by qPCR for Superoxide...
A 20-year-old Quarter Horse gelding was presented with severe right forelimb lameness (5/5 AAEP Lameness Scale) due to a tear of the superficial digital flexor muscle which diagnosed via palpation swelling and ultrasonography revealing major fiber disruption hematoma formation. When traditional systemic therapy (non-Steroidal anti-inflammatories) did not restore clinically acceptable comfort risk supporting limb laminitis became reasonable concern, cervical epidural catheter placed between...
To test the influence of increasing injectate volumes on regional effects xylazine and morphine epidural analgesia, with hypothesis that volume produces more cranial spread analgesia as determined by thermal threshold (TT) testing.
This study investigated the elongation following cyclic loading on square knots of 5 USP multifilament long-chain ultra-high molecular weight polyethylene core (UHMWPE), 2 mm woven UHMWPE tape, and braided polyester, with without cyanoacrylate glue.Experimental study.n = 4.Three conditions (suture knot, suture knot + cyanoacrylate) were evaluated for each material a mechanical test stand by measuring increased length construct after cycling from 25 to 50N 1000 repetitions at 20 mm/second....
Treatment of guttural pouch mycosis with salpingopharyngostomyAmanda R Watkins1 and Eric J Parente11University Pennsylvania New Bolton Center, Kennett Square PAThe case report by Rowe et al (2023) published in this issue describes a bilateral 9-month-old thoroughbred colt that was diagnosed due to unusual severe neurologic abnormalities including neck pain abnormal head carriage. There no evidence hemorrhage therefore the treated debridement mycotic plaques, topical enilconazole, ultimately...
No conflicts of interest have been declared.
Abstract Background Lameness is a debilitating condition in equine athletes that leads to more performance limitation and loss of use than any other medical condition. There are limited number non-terminal experimental models can be used study early inflammatory synovial fluid biophysical changes occur the joint. Here, we compare well-established carpal IL-1β-induced synovitis model tarsal intra-articular lavage model, focusing on serial cytokines/chemokines lubricating molecules...