A5100638839- Corneal Surgery and Treatments
- Vestibular and auditory disorders
- Cerebral Venous Sinus Thrombosis
- Corneal surgery and disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Genetic Associations and Epidemiology
- Ear Surgery and Otitis Media
- Occupational and environmental lung diseases
- Diabetes and associated disorders
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Air Quality and Health Impacts
- Trigeminal Neuralgia and Treatments
- Ocular Surface and Contact Lens
- Tea Polyphenols and Effects
- Vascular Malformations Diagnosis and Treatment
- Glaucoma and retinal disorders
- IL-33, ST2, and ILC Pathways
- Marine Ecology and Invasive Species
- Mechanisms of cancer metastasis
- Liver Diseases and Immunity
- Respiratory viral infections research
- Cancer-related Molecular Pathways
- Neurofibromatosis and Schwannoma Cases
Tongji Hospital
2024
Shandong University
2020-2024
Huazhong University of Science and Technology
2024
Sun Yat-sen University
2007-2022
National University of Mongolia
2022
Guangdong Pharmaceutical University
2022
Fudan University
2013-2021
Shanghai Medical Information Center
2020-2021
National Health and Family Planning Commission
2021
Ministry of Education of the People's Republic of China
2020-2021
The current genome-wide association study (GWAS) of Lewy body dementia (LBD) suffers from low power due to a limited sample size. In addition, the genetic determinants underlying LBD and shared etiology with Alzheimer's disease (AD) Parkinson's (PD) remain poorly understood.Using largest GWAS summary statistics date (2591 cases 4027 controls), late-onset AD (86,531 676,386 PD (33,674 449,056 we comprehensively investigated basis among LBD, AD, PD. We first conducted correlation analysis...
The progression of diabetic cardiomyopathy (DCM) is noticeably influenced by mitochondrial dysfunction. Variants caveolin 3 (CAV3) play important roles in cardiovascular diseases. However, the potential CAV3 function DCM and related mechanisms have not yet been elucidated.
Abstract Y-box binding protein 1 (YBX1) is involved in the development of multiple types tumors. However, relationship between YBX1 and autophagy non-small cell lung cancer (NSCLC) remains unclear. In this study, we analyzed expression clinical significance markers (LC3I/II) NSCLC examined their roles regulating sensitivity to cisplatin NSCLC. The retrospective analysis patients with indicated that was positively correlated autophagy. Increased levels or also observed cells compared those...
Although the association between hypothyroidism and idiopathic pulmonary fibrosis (IPF) is found in observational studies, it remains uncertain whether causally influences IPF.Two-sample Mendelian randomisation (MR) was conducted with genome-wide study (GWAS) data UK Biobank from 289,307 individuals (18,740 cases 270,567 controls) largest GWAS summary statistics of IPF 11,259 (2,668 8,591 controls). Findings were verified using an independent validation dataset, as well through different MR...
Long-term exposure to fine particulate matter (PM2.5) increases susceptibility chronic respiratory diseases, including inflammation and interstitial fibrosis. However, the regulatory mechanisms by which immune response mediates initiation of pulmonary fibrosis has yet be fully characterized. This study aimed illustrate interplay between different cell clusters key pathways in triggering lung injuries mice following PM exposure.Six-week-old C57BL/6J male were exposed or filtered air for 16...
Importance Tirofiban is a nonpeptide antagonist of the glycoprotein IIb/IIIa receptor that inhibits platelet aggregation selectively. Despite widespread use in acute ischemic stroke conjunction with endovascular treatment, role tirofiban uncertain. Objective To assess whether intravenous initiated before thrombectomy improves outcomes by achieving first-pass recanalization without intracranial hemorrhagic risk. Design, Setting, and Participants This was multicenter, prospective, open-label,...
To show that mechanical compression of sigmoid sinus is effective for treatment pulsatile tinnitus caused by enlargement, and to evaluate the relationship between degree symptom relief using magnetic resonance angiography.Medical records twenty-four patients who were diagnosed with venous enlargement underwent reviewed April 2009 May 2013. All these received computed tomography venography study before undergoing surgery followed at least 4 months.Twenty-three felt from three months after...
Objective This study was performed to evaluate the prevalence and clinical importance of elevated cerebrospinal fluid (CSF) pressure among patients with pulse-synchronous tinnitus. Methods Nineteen underwent height weight measurements, routine otologic examinations, ear computed tomography, brain magnetic resonance imaging, fundus examination, tinnitus score assessment. We analyzed data Fisher’s exact test, t-test, Pearson’s correlation. Results The mean age 19 39.2 ± 8.1 years (range, 27–54...
Nitidine chloride (NC) has been reported to exert its anti-tumor activity in various types of human cancers. However, the molecular mechanism NC-mediated tumor suppressive function is largely unclear. In current study, we used several approaches such as MTT, FACS, RT-PCR, Western blotting analysis, invasion assay, transfection, explore basis NC-triggered anti-cancer activity. We found that NC inhibited cell growth, induced apoptosis, caused cycle arrest ovarian cancer cells. Emerging...
To explore genes potentially co-expressed with cyclin E in gastric cancer and discover possible targets for treatment.The Cancer Genome Atlas (TCGA) stomach adenocarcinoma sequencing data were used to predict E. Co-expression predicted by cBioPortal online analysis Pearson correlation coefficient ≥0.4 analyzed gene ontology (GO) enrichment annotation using the PANTHER platform (Ver. 7). Interactions between proteins encoded these STRING 10.5) Cytoscape software 3.5.1). Genes displaying a...
Idiopathic pulmonary fibrosis (IPF) is a type of scarring lung disease characterized by chronic, progressive, and irreversible decline in function. The genetic basis IPF remains elusive. A transcriptome-wide association study (TWAS) was performed FUSION using gene expression weights three tissues combined with large-scale genome-wide (GWAS) dataset, totally involving 2,668 cases 8,591 controls. Significant genes identified TWAS were then subjected to ontology (GO) pathway enrichment...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most prevalent chronic diseases. In patients CRSwNP, present study performed comprehensive bioinformatics analyses to characterize transcriptome profiles mRNAs and long non‑coding RNAs (lncRNAs). A total 265 differentially expressed lncRNAs 994 were identified. The majority up‑ downregulated genes significantly enriched in biological process 'signal transduction'. molecular function was 'protein binding' cellular component...
Vestibular schwannoma (VS) is benign, slow-growing brain tumor that negatively impacts patient quality of life, which may cause even death. This study aimed to explore key genes and microRNAs (miRNAs) associated with VS.