A5100415540- Nanoplatforms for cancer theranostics
- COVID-19 and Mental Health
- Resilience and Mental Health
- Gynecological conditions and treatments
- Child and Adolescent Psychosocial and Emotional Development
- Reproductive System and Pregnancy
- Nanoparticle-Based Drug Delivery
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Genetic Associations and Epidemiology
- Ultrasound and Hyperthermia Applications
- Family and Disability Support Research
- DNA Repair Mechanisms
- Sleep and related disorders
- CRISPR and Genetic Engineering
- Curcumin's Biomedical Applications
- Growth Hormone and Insulin-like Growth Factors
- Child Abuse and Trauma
- Ectopic Pregnancy Diagnosis and Management
- Psychological Well-being and Life Satisfaction
- Graphene and Nanomaterials Applications
- Aldose Reductase and Taurine
- Cancer Mechanisms and Therapy
- Advanced Computing and Algorithms
- Posttraumatic Stress Disorder Research
Shandong University
2013-2024
Beijing Tian Tan Hospital
2024
Capital Medical University
2024
West China Medical Center of Sichuan University
2024
First Hospital of Jilin University
2023-2024
Jilin University
2023-2024
Creative Commons
2023
Institut de Médecine de la Reproduction
2023
Wuhan University of Science and Technology
2020-2022
The University of Sydney
2022
Abstract Fibrotic tissue may contribute to the origin of some endometriosis-related symptoms, such as chronic pelvic pain and infertility. Alterations in H19/miR-216a-5p/ACTA2 pathway mediate regulation eutopic endometrial stromal cell (euESC) invasion migration represent a potential mechanism underlying fibrous formation or fibrosis women with endometriosis. In this study, we aimed determine expression H19 ACTA2 tissues Two groups 23 infertile endometriosis matched without were...
The current genome-wide association study (GWAS) of Lewy body dementia (LBD) suffers from low power due to a limited sample size. In addition, the genetic determinants underlying LBD and shared etiology with Alzheimer's disease (AD) Parkinson's (PD) remain poorly understood.Using largest GWAS summary statistics date (2591 cases 4027 controls), late-onset AD (86,531 676,386 PD (33,674 449,056 we comprehensively investigated basis among LBD, AD, PD. We first conducted correlation analysis...
DTX/CS–Rh–PFC nanoparticles are hydrolyzed by glutathione in tumor cells, releasing DTX and oxygen molecules, thus exhibit good anti-tumor ability.
Abstract Background Lung cancer is the most common type of tumour worldwide. Its relative lethality considerably high. However, since tissues are located deep within human body, traditional technologies, such as photodynamic therapy, do not have desired effect. Sonosensitisers can penetrate deeply into tissues, and sonodynamic therapy (SDT) effectively inhibits tumours by generating reactive oxygen species. Ultrasound also deeply, with a favourable inhibition Results A...
Although the association between hypothyroidism and idiopathic pulmonary fibrosis (IPF) is found in observational studies, it remains uncertain whether causally influences IPF.Two-sample Mendelian randomisation (MR) was conducted with genome-wide study (GWAS) data UK Biobank from 289,307 individuals (18,740 cases 270,567 controls) largest GWAS summary statistics of IPF 11,259 (2,668 8,591 controls). Findings were verified using an independent validation dataset, as well through different MR...
Since coronavirus disease 2019 (COVID-19) outbreak, its terrible infectiousness has caused great panic, anxiety and poor sleep quality to the vulnerable adolescent populations.
Aim: To investigate associations between family cohesion and adaptability level of secondary school students the prevalence CSA. Method: A retrospective study conducted in rural middle Hubei province, central China. The correlation adaptability, risk factors CSA were tested by an anonymous self-completed questionnaire FACES II-CV 3082 students. Result: total ratio is 20.8%. Boys (25.7% vs 14.9%, P<0.05), senior (25.4% 17.4%, P<0.05) left-behind children (22.0% 18.0%, got higher rate...
Background: Child sexual abuse (CSA) is a global public health problem, which has significant impact, and the situation not optimistic. Objectives: The aim was to investigate prevalence rate influencing factors of CSA among school-aged children in rural central China. Participants Setting: were recruited from schools reflect Hubei Province A total 3,940 (2,085 boys 1,855 girls) China participated this study. Methods: tested through utilization anonymous self-administered questionnaires,...
Stigma has emerged as one of the major obstacles to effectively diagnosing depression, it prevents users from open conversations about their struggles. This requires advanced questioning skills carefully probe presence specific symptoms in an unobtrusive manner. While recent efforts have been made on depression-diagnosis-oriented dialogue systems, they largely ignore this problem, ultimately hampering practical utility. To end, we propose a novel and effective method, UPSD$^{4}$, developing...
Abstract The association between thyroid function and dyslipidemia has been well documented in observational studies. However, studies are prone to confounding, making it difficult conduct causal inference. We performed a 2-sample bidirectional Mendelian randomization (MR) using summary statistics from large-scale genome-wide of stimulating hormone (TSH), free T4 (FT4), blood lipids. chose the inverse variance–weighted (IVW) method for main analysis, consolidated results through various...
Meiotic crossovers are required for the faithful segregation of homologous chromosomes and to promote genetic diversity. However, it is unclear how crossover formation regulated, especially on XY chromosomes, which show a homolog only at tiny pseudoautosomal region. Here, we that ATF7IP2 meiosis-specific ortholog ATF7IP partner SETDB1. In absence ATF7IP2, autosomes increased axis length more crossovers; however, many lose obligatory crossover, although overall also increased. Additionally,...
The successful progression of meiosis prophase I requires integrating information from the structural and molecular levels. In this study, we show that ZFP541 KCTD19 work in same genetic pathway to regulate male thus fertility. Zfp541 and/or Kctd19 knockout mice various recombination defects including detached chromosome ends, aberrant localization axis components proteins, globally altered histone modifications. Further analyses on RNA-seq, ChIP-seq, ATAC-seq data provide evidence for above...
To study whether infertile patients with endometriosis have a higher prevalence of endometrial polyps, and to clarify the characteristics pathology combined polyps.Infertile who had undergone both hysteroscopy laparoscopy in Reproductive Hospital Affiliated Shandong University from January 2014 May 2017 were enrolled. Patients without endometriosis, diagnosed by laparoscopy, staged included group control group, respectively, polyps was compared. The pathological types analyzed.A total 414...
Molybdenum oxide (MoOx) nanosheets have drawn increasing attention for minimally invasive cancer treatments but still face great challenges, including complex modifications and the lack of efficient accumulation in tumor. In this work, a novel multifunctional degradable FA-BSA-PEG/MoOx nanosheet was fabricated (LA-PEG FA-BSA dual modified MoOx): synergistic effect PEG BSA endows with excellent stability compatibility; FA, targeting ligand, facilitates addition, DTX, model drug breast...
The global coronavirus disease 2019 (COVID-19) pandemic seriously affected people's lives. We evaluated anxiety and depression among patients with insomnia in northeast China during the first wave release of COVID-19, providing a basis for clinical diagnosis treatment insomnia.
Although recent studies have indicated that mutations in the gene encoding diacylglycerol kinase epsilon (DGKE) result some proteinuria related hereditary kidney diseases, DGKE expression pattern and its contribution to acute injury (AKI) remain unknown. Therefore, present study was designed detect role of mice with AKI. time-dependently altered kidneys renal ischemia/reperfusion (IRI). Compared wild-type (WT) mice, DGKE- overexpressing (Rosa26-Dgke+/+) exhibited protective effects against...