A5100622424- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Intracranial Aneurysms: Treatment and Complications
- Epigenetics and DNA Methylation
- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Neuroblastoma Research and Treatments
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced Neuroimaging Techniques and Applications
- Genomics, phytochemicals, and oxidative stress
- Porphyrin Metabolism and Disorders
- Pluripotent Stem Cells Research
- Histone Deacetylase Inhibitors Research
- SARS-CoV-2 and COVID-19 Research
- Neuroscience and Neuropharmacology Research
Kunming Medical University
2013-2025
Renji Hospital
2024
Shanghai Jiao Tong University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2017-2021
Chongqing Medical University
2011-2016
Huazhong University of Science and Technology
2002
Background: Mechanical thrombectomy is effective and safe for treating pulmonary embolism (PE). Although the Tendvia mechanical system has been validated in pigs, further evidence supporting its use PE treatment needed. Objectives: This study was aimed at evaluating safety efficacy of intermediate-risk acute PE. Methods: prospective, single-arm, multicenter included symptomatic patients with ≥18 years age, a right ventricular (RV)/left (LV) diameter ratio ≥0.9. The primary endpoint change...
Gliomas are the most aggressive type of malignant brain tumors.Recent studies have demonstrated that existence glioma stem cells (GSCs) is critical for recurrence, metastasis, and chemo-or radio-therapy resistance.Temozolomide (TMZ) has been used as an initial therapy gliomas.However, overall survival time still limiting due to lack effective targets treatment options.Therefore, identifying novel biomarkers gliomas, especially GSCs, important improve clinical outcome in future.In this study,...
Abstract HACE1, an E3 ubiquitin-protein ligase, is frequently inactivated and has been evidenced as a putative tumor suppressor in different types of cancer. However, its role glioma remains elusive. Here, we observed increased expression HACE1 gliomas related to control subjects, found strong correlation high with poor prognosis patients WHO grade III IV well low-grade (LGG) receiving radiotherapy. knockdown obviously suppressed malignant behaviors cells, while ectopic enhanced cell growth...
We revealed that SNX20 was up-regulated in LGG, and its higher expression associated with adverse clinical outcomes poor characteristics, including WHO grade, IDH mutation, 1p/19q codeletion, primary therapy outcome. The results of the Cox regression analysis an independent factor for prognosis low-grade glioma. Meanwhile, we also established a nomogram based on to predict 1-, 3-, or 5-year survival LGG patients. Furthermore, found DNA hypomethylation overexpression LGG. In addition,...
Efficient gene delivery vectors are crucial for respiratory and lung disease therapies. We report that AAV.CPP.16, an engineered adeno-associated virus (AAV) variant derived from AAV9, efficiently transduces airway cells in mice non-human primates via intranasal administration. AAV.CPP.16 outperforms AAV6 two wild-type AAVs with demonstrated tropism tissues, targets key cell types. It supports supplementation editing therapies clinically relevant mouse models of diseases. A single dose...
Lung adenocarcinoma (LUAD) is the most common histological lung cancer, and it leading cause of cancer-related deaths worldwide. Long noncoding RNAs (lncRNAs) have been implicated in initiation progression various cancers. LncRNA-AC099850.3 a novel lncRNA that abnormally expressed diverse cancer types including LUAD. However, clinical significance, prognostic value, diagnostic immune role, potential biological function AC099850.3 LUAD remain elusive. In this study, we found was highly...
Glioblastoma (GBM) is the most common and malignant primary brain tumor. stem cells (GSCs) not only initiate sustain uncontrolled cell proliferation but also resistant to conventional clinical therapies including temozolomide (TMZ) dependent chemotherapy radiotherapy, implying that there an urgent need identify new therapeutic strategies especially specific targeting GSCs. Here, we provide evidence showing ivacaftor commonly applied in cystic fibrosis therapy acts as a potent inhibitor for...
Non-SMC condensin I complex subunit G (NCAPG) is expressed in various human cancers, including gliomas. However, its biological function glioma remains unclear. The present study was designed to determine the functions of NCAPG and evaluate association expression with progression. Clinical data on patients were obtained from Cancer Genome Atlas (TCGA), Chinese Glioma (CGGA), Gene Expression Omnibus (GEO), Rembrandt Gravendeel databases. correlations among expression, pathological...
From a cDNA library of Chinese scorpion Buthus martensii Karsch, full‐length cDNAs 351 nucleotides encoding precursors (named BmKIM) that contain signal peptides 21 amino acid residues, mature toxin 61 residues with four disulfide bridges, and an extra Gly‐Lys‐Lys tail, were isolated. The genomic sequence BmKIM was cloned sequenced; it consisted two exons disrupted by intron 1622 bp, the largest known in genomes, inserted region peptide. expressed Escherichia coli . recombinant toxic to both...
Protein casein 2A2 (BTN2A2) is a costimulatory molecule first identified in antigen-presenting cells. Studies have shown the involvement of BTN2A2 immunity. However, exact role and mechanism tumors are still unclear.First, we performed real-time PCR to measure expression glioma cell lines. Next, Genes Ontology (GO) Kyoto Encyclopedia Genomes (KEGG) enrichment analyses understand glioma. used "ESTIMATE", "ssGSEA" "CIBERSORT" algorithms analyze correlation between immune infiltration (ICI)....
Sterile alpha motif (SAM) and Src homology-3 (SH3) domain-containing 3 (SASH3) is an adaptor protein expressed mainly in lymphocytes, plays significant roles T-cell proliferation cell survival. However, its expression level, clinical significance, correlation with tumor-infiltrating immune cells across cancers remain unclear. In this study, we comprehensively examined the expression, dysregulation, prognostic significance of SASH3, clinicopathological parameters infiltration pan-cancer. The...
Background: This study aimed to compare the risk and benefit profile of microsurgery (MS) stereotactic radiosurgery (SRS) as first-line treatment for unruptured ruptured arteriovenous malformations (AVMs). Materials Methods: We included AVMs underwent MS or SRS from a nationwide prospective multicenter registry in *BLINDED*. used propensity score-matched methods balance baseline characteristics between groups. The primary outcomes were long-term hemorrhagic stroke death, secondary...
The aim of this study was to investigate copy number ErbB family members (including EGFR, HER2, HER3 and HER4) in a cohort gliomas benign meningiomas (control subjects), explore the associations their with clinicopathological characteristics clinical outcomes glioma patients. Using real-time quantitative PCR assay, we demonstrated that HER4 patients significantly increased compared control subjects. Moreover, our data also showed risk cancer-related death positively associated gain (CNG)...