A5100625529- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Atrial Fibrillation Management and Outcomes
- Tissue Engineering and Regenerative Medicine
- Air Quality Monitoring and Forecasting
- Advanced biosensing and bioanalysis techniques
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Fibrosis and Remodeling
- MicroRNA in disease regulation
- Carbon Nanotubes in Composites
- Selenium in Biological Systems
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- Folate and B Vitamins Research
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac Arrhythmias and Treatments
- Spaceflight effects on biology
- Energy and Environment Impacts
- Circular RNAs in diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Diamond and Carbon-based Materials Research
- Dendrimers and Hyperbranched Polymers
- Hydrogen's biological and therapeutic effects
- Biomarkers in Disease Mechanisms
- Medical and Biological Ozone Research
Renji Hospital
2019-2025
Shanghai Jiao Tong University
2015-2025
Hebei Provincial Center for Disease Control and Prevention
2024
State Key Laboratory of Oncogene and Related Genes
2022
First People’s Hospital of Jingmen
2018-2021
XinHua Hospital
2015-2020
Henan Academy of Sciences
2018
Fourth Affiliated Hospital of Guangxi Medical University
2018
Bridge University
2014
Zhongshan Hospital
2011
Abstract Endothelial‐mesenchymal transition (EndMT) is a major source of transformed cardiac fibroblasts, which reported to play key role in fibrosis (CF), pathogenesis cardiovascular diseases such as heart failure, myocardial infarction and atrial fibrillation. Nonetheless, the specific mechanism underlying progression EndMT CF still largely unknown. In this study, we aimed investigate milk fat globule‐EGF factor 8 (MFGE8), kind soluble glycoprotein, TGF‐ β 1‐induced EndMT. animal...
Human pluripotent stem cells (hPSCs) are a powerful platform for disease modeling and drug discovery. However, the introduction of known pathogenic mutations into hPSCs is time-consuming labor-intensive process. Base editing newly developed technology that enables facile point specific loci within genome living cells. Here, we design an all-in-one episomal vector expresses single guide RNA (sgRNA) with adenine base editor (ABE) or cytosine (CBE). Both ABE CBE can efficiently introduce cells,...
The cardiac repair process following a myocardial infarction is key factor in patient prognosis. In this process, fibrosis takes critically important role. Among those featured genes for fibrosis, transforming growth beta (TGF-β) known to be involved the various organs. And bone morphogenetic protein (BMP)6 belongs TGF-β superfamily. Although BMPs are play exclusive roles processes, character of BMP6 remodelling remains unclear.This study aimed investigate how functioned (MI).In paper, we...
Coronary artery disease is a major cause of morbidity and mortality worldwide. Impaired endothelial function integrity are contributory factors to coronary disease. Micro RNA s have been proposed play an important role in pathogenesis. In the present study, expression miR‐206 was found be significantly upregulated peripheral blood progenitor cells from patients with compared healthy donors. MiR‐206 regulate cell activities by targeting protein kinase PIK 3C2α, which showed decreased cells....
Background. Apoptosis plays vital roles in the progression of doxorubicin-induced cardiomyopathy (DOX-CM). Endoplasmic reticulum stress (ER stress) could induce specific apoptosis by caspase-12 dependent pathway. Shengmai Injection (SMI), a famous Traditional Chinese Medicine, alleviate heart damage via inhibiting myocardial apoptosis. However, it is unknown whether SMI can ER and its setting DOX-CM. Objective. To explore effects on function, stress, DOX-CM rats. Methods. Rats with were...
Natural compounds like pterostilbene (PTE) have gained recognition for their various biological activities and potential health benefits. However, challenges related to bioavailability limited clinical efficacy prompted efforts strengthen therapeutic potential. To meet these challenges, we herein rationally designed successfully synthesized a pharmaceutical phosphoramidite that allows the programmable incorporation of PTE into oligonucleotides. The resultant aptamer-PTE conjugate can...
We aimed to investigate whether miR-181d may be involved in steroid-induced osteonecrosis of the femoral head (ONFH) and its underlying mechanism.Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) was used detect expression bone marrow 5 cases necrosis secondary neck fractures. Marrow-derived mesenchymal stem cells (MSCs) were obtained from samples identified. Subsequently, effects on osteogenic differentiation evaluated by alizarin red staining alkaline phosphatase....
Objectives: Traffic-related particulate matter (PM) is one of the major sources air pollution in metropolitan areas.This study to observe interactive effects gene and fine particles (particles smaller than 2.5 μm -PM ) on respiratory system explore mechanisms linking PM pulmonary injury.Material Methods: The participants include 110 traffic policemen 101 common populations Shanghai, China.Continuous 24 h individual-level detected function, high-sensitivity C-reactive protein (hs-CRP), Clara...
Abstract Lepidoptera sex pheromone biosynthesis is regulated by activating neuropeptide (PBAN). PBAN regulates not only female but also male biosynthesis. Previous research has confirmed that using Ca 2+ as a secondary messenger in all examined species to date. However, the downstream signal of remained elusive. In present study, calcineurin A (CNA), , was discovered Helicoverpa armigera hairpencil and named HaCNA. Sequence analysis demonstrated open reading frame HaCNA contains 1488...
Circular RNAs are considered to be associated with cancer resistance. This study aims investigate the function and mechanism of circMYBL2 in paclitaxel (PTX) resistance cervical (CC). The expression circMYBL2, miR-665 epidermal growth factor receptor (EGFR) was investigated using quantitative real-time polymerase chain reaction assay. Cell viability, cell colony number, proliferation, apoptosis lactate dehydrogenase (LDH) were detected by 3-(4, 5-Dimethylthiazol-2-yl)-2,...
Objective: The aim of this study was to explore the association between individual PM2.5 and DNA damage in traffic policemen. Methods: participants included 110 policemen 101 common populations. continuous 24-hour measurement performed participants. BPDE (benzo[a]pyrene 7,8-diol-9,10-epoxide)-DNA adducts 1-OHP were detected. Results: average concentration personal for significantly higher than that control group. exposure is associated with a 1.1% increase 0.8% BPDE-DNA after adjusted body...
Parental exposure to ambient fine particulate matter (PM2.5) has been associated with some of adverse health outcomes in offspring. The association between parental PM2.5 and the development metabolic syndrome (MetS) offspring, effects on susceptibility offspring mice PM2.5, not evaluated. C57BL/6 (male female mice) were exposed filtered air (FA) or concentrated (PM) using Shanghai-METAS for a total 16 weeks. At week 12 during exposure, we allowed male breed mice. divided into 4 groups PM FA...
Colorectal cancer (CRC) is one of the most common malignances worldwide. Chemoresistance remains a major issue in field CRC treatment. The present study aimed to investigate potential role polo-like kinase 2 (Plk2) chemoresistance CRC. associations between Plk2 and clinicopathological factors, as well chemotherapeutic benefit were analyzed with publicly available dataset. correlation expression chemosensitivity was further confirmed cells. Moreover, knockdown exogenous overexpression...
Lots of epidemiological and experimental studies have found that ambient fine particulate matter (PM2.5) exposure is associated with the development cardiopulmonary diseases, obesity diabetes. This study focused on effects cumulative PM2.5 pulmonary systemic inflammation insulin resistance. Thirty-two 6-week-old male Balb/c mice were randomly divided into four groups (FA, PM, WEEK DAY groups) continuously or intermittently exposed to concentrated filtered air (FA) for weeks using Shanghai...