A5100638840- Angiogenesis and VEGF in Cancer
- Muscle Physiology and Disorders
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Cancer-related gene regulation
- RNA modifications and cancer
- Mesenchymal stem cell research
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Melanoma and MAPK Pathways
- Genetic factors in colorectal cancer
- Virus-based gene therapy research
- Multiple Myeloma Research and Treatments
- Carcinogens and Genotoxicity Assessment
- High Altitude and Hypoxia
- Peroxisome Proliferator-Activated Receptors
- Estrogen and related hormone effects
- Neuroscience of respiration and sleep
- Nuclear Structure and Function
- Exercise and Physiological Responses
- Chromatin Remodeling and Cancer
- Air Quality and Health Impacts
- Ubiquitin and proteasome pathways
- Quinazolinone synthesis and applications
Northwestern Polytechnical University
2025
Shandong University
2021-2025
Dalian Medical University
2018-2024
Second Affiliated Hospital of Dalian Medical University
2018-2024
Steadman Philippon Research Institute
2018-2023
Huazhong University of Science and Technology
2023
Tongji Hospital
2023
Sun Yat-sen University
2017-2022
Nanyang Medical College
2019-2021
Shandong University of Traditional Chinese Medicine
2021
Abstract Acquisition of a metastatic phenotype by breast cancer cells includes alternations multigenic programs that permit tumor to metastasize distant organs. Here, we report angiopoietin-2 (Ang2), known growth factor, is capable promoting cell invasion leading metastasis. Analysis 185 primary human specimens include 97 tumors showing lymph node and/or metastasis reveals significant correlation between the expression Ang2 and E-cadherin, Snail, potential, grade, lymph-vascular during...
Aging leads to several geriatric conditions including osteoporosis (OP) and associated frailty syndrome. Treatments for these are limited none target fundamental drivers of pathology, thus identifying strategies delay progressive loss tissue homeostasis functional reserve will significantly improve quality life in elderly individuals. A property aging is the accumulation senescent cells. Senescence a cell state defined by proliferative capacity, resistance apoptosis, release proinflammatory...
A hallmark of highly malignant human gliomas is their infiltration the brain. We analyzed a large number primary glioma biopsies and found high levels expression an angiogenic regulator, angiopoietin-2 (Ang2), in invasive areas, but not central regions, those tumors. In regions where Ang2 was overexpressed, increased matrix metalloprotease-2 (MMP-2) were also apparent. Consonant with these features, intracranial xenografts cells engineered to express into adjacent brain parenchyma compared...
Bromodomain PHD finger transcription factor (BPTF), a core subunit of nucleosome-remodeling (NURF) complex, plays an important role in chromatin remodeling. However, its precise function and molecular mechanism involved hepatocellular carcinoma (HCC) growth are still poorly defined. Here, we demonstrated the tumor-promoting BPTF HCC progression. was highly expressed cells tumor tissues patients compared with normal liver tissues. Knockdown inhibited cell proliferation, colony formation stem...
Abstract Background As the selective inhibitor of BRAF kinase, vemurafenib exhibits effective antitumor activities in patients with V600 mutant melanomas. However, acquired drug resistance invariably develops after its initial treatment. Methods Immunohistochemical staining was performed to detect expression iNOS and hTERT, p-p65, Epcam, CD44, PCNA mice melanoma xenografts. The proliferation migration cells were detected by MTT, tumorsphere culture, cell cycle, apoptosis, AO/EB assay colony...
Vascular endothelial growth factor (VEGF) is a potent angiogenic stimulator that acts by binding to high-affinity transmembrane receptors. Although both VEGF and its receptors are overexpressed in human pancreatic ductal adenocarcinoma (PDAC), this malignancy not generally considered be highly vascular. It known, therefore, whether the abundance of PDAC biologically relevant. To address issue, we measured effects cancer cell-derived an vitro cell proliferation assay characterized...
The Functional Movement Screen (FMS) is a critical tool for assessing an individual’s basic motor abilities, aiming to prevent sports injuries. However, current automated FMS evaluation based on deep learning methods, and the of actions limited rank scoring, which lacks fine-grained feedback suggestions has poor interpretability. This limitation prevents effective application injury prevention rehabilitation. We develop fine-grained, hierarchical dataset, LLM-FMS, derived from videos...
Angiogenesis is required for lung cancer growth, which mediated by various growth factors such as vascular endothelial factor (VEGF). Increases in VEGF and angiogenesis have been correlated with poor prognosis survival patients cancer. In addition, recent reports show that estradiol nicotine play important roles tumor initiation progression. this report, we demonstrate exposure enhances the of A549 bronchioloalveolar carcinoma xenografts mice through stimulation cell proliferation, secretion...
The mediator complex usually cooperates with transcription factors to be involved in RNA polymerase II-mediated gene transcription. As one component of this complex, MED27 has been reported our previous studies promote thyroid cancer and melanoma progression. However, the precise function breast development remains poorly understood. Here, we found that was more highly expressed samples than normal tissues, especially triple-negative cancer, its expression level elevated increase...
By restraining proliferation and promoting apoptosis, resveratrol (RES) has anti-tumor effect in various cancers. Here, we examine whether RES exerts similar drug-resistant renal cell carcinoma (RCC). To this end, Caki-1 cells derived from are subjected to escalated doses of paclitaxel (PTX) produce the PTX resistant Caki-1PTX cells. Both Caki-PTX sensitive PTX, a dose dependent manner. RES, dose-dependently, suppresses expression survivin, molecular biomarker cancer member inhibitor...
Diabetic cardiomyopathy (DCM), characterized by mitochondrial dysfunction and impaired energetics as contributing factors, significantly contributes to high mortality in patients with diabetes. Targeting key proteins involved might offer new therapeutic possibilities for DCM. Lentinan (LNT), a β-(1,3)-glucan polysaccharide obtained from lentinus edodes, has demonstrated biological activity modulating metabolic syndrome. In this study, the authors investigate LNT's pharmacological effects on...
Chronic benzene exposure is associated with hematotoxicity and the development of aplastic anemia leukemia. However, signaling pathways underlying benzene-induced remain to be defined. Here, we investigated role protein phosphatase 2A (PP2A) in regulation a murine model. Male mice hepatocyte-specific homozygous deletion Ppp2r1a gene (encoding PP2A Aα subunit) (HO) matched wildtype (WT) were exposed via inhalation at doses 1, 10, 100 ppm for 28 days. Peripheral white blood cell counts...
Abstract The association between thyroid function and dyslipidemia has been well documented in observational studies. However, studies are prone to confounding, making it difficult conduct causal inference. We performed a 2-sample bidirectional Mendelian randomization (MR) using summary statistics from large-scale genome-wide of stimulating hormone (TSH), free T4 (FT4), blood lipids. chose the inverse variance–weighted (IVW) method for main analysis, consolidated results through various...
Abstract It remains challenging to translate the findings from genome-wide association studies (GWAS) of autoimmune diseases (AIDs) into interventional targets, presumably due lack knowledge on how GWAS risk variants contribute AIDs. In addition, current immunomodulatory drugs for AIDs are broad in action rather than disease-specific. We performed a comprehensive protein-centric omics integration analysis identify AIDs-associated plasma proteins through integrating protein quantitative trait...