A5033590040- Melanoma and MAPK Pathways
- Computational Drug Discovery Methods
- Multiple Myeloma Research and Treatments
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Cutaneous Melanoma Detection and Management
- Mechanisms of cancer metastasis
- Chromatin Remodeling and Cancer
- Telomeres, Telomerase, and Senescence
- Cytokine Signaling Pathways and Interactions
- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
Dalian Medical University
2018-2024
Second Affiliated Hospital of Dalian Medical University
2018-2024
First Affiliated Hospital of Dalian Medical University
2020
Bromodomain PHD finger transcription factor (BPTF), a core subunit of nucleosome-remodeling (NURF) complex, plays an important role in chromatin remodeling. However, its precise function and molecular mechanism involved hepatocellular carcinoma (HCC) growth are still poorly defined. Here, we demonstrated the tumor-promoting BPTF HCC progression. was highly expressed cells tumor tissues patients compared with normal liver tissues. Knockdown inhibited cell proliferation, colony formation stem...
Abstract Background As the selective inhibitor of BRAF kinase, vemurafenib exhibits effective antitumor activities in patients with V600 mutant melanomas. However, acquired drug resistance invariably develops after its initial treatment. Methods Immunohistochemical staining was performed to detect expression iNOS and hTERT, p-p65, Epcam, CD44, PCNA mice melanoma xenografts. The proliferation migration cells were detected by MTT, tumorsphere culture, cell cycle, apoptosis, AO/EB assay colony...
Human telomerase reverse transcriptase (hTERT) plays an extremely important role in cancer initiation and development, including colorectal (CRC). However, the precise upstream regulatory mechanisms of hTERT different types remain poorly understood. Here, we uncovered candidate transcriptional factor CRC explored its corresponding molecular regulating expression survival with aim developing mechanism-based combinational targeting therapy. The possible binding proteins at promoter were using...