A5082600587- Protein Kinase Regulation and GTPase Signaling
- Wnt/β-catenin signaling in development and cancer
- Pneumonia and Respiratory Infections
- Animal Genetics and Reproduction
- Melanoma and MAPK Pathways
- Antibiotic Resistance in Bacteria
- Cellular Mechanics and Interactions
- Cancer Cells and Metastasis
- Cervical Cancer and HPV Research
- Ubiquitin and proteasome pathways
- TGF-β signaling in diseases
- Cancer survivorship and care
- Pain Mechanisms and Treatments
- Microtubule and mitosis dynamics
- Cytokine Signaling Pathways and Interactions
- Retinoids in leukemia and cellular processes
- HER2/EGFR in Cancer Research
- Viral Infections and Vectors
- Gestational Diabetes Research and Management
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
- Medical Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Mechanisms of cancer metastasis
- Endometrial and Cervical Cancer Treatments
First Affiliated Hospital of Anhui Medical University
2019-2025
Anhui Medical University
2011-2025
Sichuan University
2011-2025
West China Second University Hospital of Sichuan University
2011-2025
Fudan University
2024
Shanghai Medical College of Fudan University
2024
Harbin Medical University
2024
Fudan University Shanghai Cancer Center
2024
Dalian Medical University
2019-2023
First Affiliated Hospital of Dalian Medical University
2020-2023
Abstract Despite the high mortality from metastatic cancer, therapeutic targets to prevent metastasis are limited. Efforts identify genetic aberrations that predispose tumors have been mostly unsuccessful. To understand nature of candidate for disease, we performed an in silico screen drugs can inhibit a gene expression signature associated with epithelial–mesenchymal transition (EMT). Compounds discovered through this method, including those previously identified, appeared restrict capacity...
Abstract Intercellular communication often relies on exosomes as messengers and is critical for cancer metastasis in hypoxic tumor microenvironment. Some circular RNAs (circRNAs) are enriched cell‐derived exosomes, but little known about their ability to regulate intercellular metastasis. Here, by systematically analyzing secreted non‐small cell lung (NSCLC) cells, a hypoxia‐induced exosomal circPLEKHM1 identified that drives NSCLC through polarizing macrophages toward M2 type....
Abstract Background: Increased cell-free DNA (cf-DNA) and the integrity of cf-DNA in plasma patients with cancer has been described. We investigated clinical utility detection monitoring progression leukemia. Methods: Plasma samples from 60 acute leukemia were analyzed comparison to 30 healthy controls. was determined by quantitative PCR (qPCR) amplifying β-actin gene ( ACTB ). The index calculated as ratio qPCR results 384/106). Paired diagnostic/complete remission (CR)/relapse eight...
Net1 is a RhoA guanine nucleotide exchange factor (GEF) that overexpressed in subset of human cancers and contributes to cancer cell motility invasion vitro. However, the molecular mechanism accounting for its role has not been described. In present work, we show expression both isoforms breast cells required efficient motility. Although loss isoform only partially blocks activation, it inhibits lysophosphatidic acid (LPA)-stimulated migration as efficiently knockdown itself. demonstrate...
A majority of people who have sustained spinal cord injury (SCI) experience chronic pain after injury, and this is highly resistant to available treatments. Contusive SCI in rats at T10 results hyperexcitability primary sensory neurons, which contributes pain. KCNQ channels are widely expressed nociceptive dorsal root ganglion (DRG) important for controlling their excitability, activation has proven effective reducing peripheral nerve inflammation models. The possibility that activators...
Cisplatin is one of the most potent chemotherapeutic agents for treatment colon cancer.Nevertheless, unavoidability notable toxicity and development acquired resistance severely restricted its clinical application.Aspirin some other non-steroidal anti-inflammatory drugs have been used to prevent tumorigenesis as chemopreventive agents.Here, we explored possibility aspirin an adjuvant drug boost anti-cancer effect cisplatin cancer.We found that significantly enhanced cisplatin-mediated...
Abstract Prolonged viral shedding may pose a threat to the control of coronavirus disease‐2019 (COVID‐19), and data on duration severe acute respiratory syndrome 2 (SARS‐CoV‐2) are still limited, with associated factors being unknown. All adult patients laboratory‐confirmed COVID‐19 were included in this retrospective cross‐sectional study two designated hospitals during 21 January 2020 16 March Anhui, China. In all patients, SARS‐CoV‐2 RNA analyzed by reviewing detection results...
Maternal nutrition is associated with premature rupture of membranes (PROM), which affects 6.7-10.0% term pregnancies and poses significant health challenges for both mothers children. However, the relationship between body composition, a detailed reflection maternal nutrition, PROM remains under-explored. We conducted retrospective correlational study using data from 38,610 obstetric cases (PROM = 9,857; non-PROM 28,753) in hospital information system West China Second University Hospital....
Background: C arbapenem-resistant Klebsiella pneumoniae (CRKP) infections may increase the potential for mortality in kidney transplant (KT) recipients. This study aimed to investigate clinical features, molecular epidemiology, virulence, and antimicrobial resistance of KP strains from KT patients. Methods: Strains isolated patients were collected, susceptibility analysis was verified via Vitek2 compact instrument disc diffusion method. In gene expression analysis, carbapenemase genes...
Large Language Model (LLM) artificial intelligence (AI) tools have the potential to streamline healthcare administration by enhancing efficiency in document drafting, resource allocation, and communication tasks. Despite this potential, adoption of such among hospital administrators remains understudied, particularly at individual level. To explore factors influencing utilization LLM AI China, focusing on enablers, barriers, practical applications daily administrative A multi-center,...
<sec> <title>BACKGROUND</title> The rapid integration of artificial intelligence (AI) in healthcare is transforming hospital operations and administrative processes. In this context, human resource (HR) managers are increasingly challenged to incorporate AI skills into workforce competencies support both clinical functions. However, investigation HR managers' subjective perspectives remains lacking. </sec> <title>OBJECTIVE</title> To explore on mandating as essential competencies, with a...
K-Ras must localize to the plasma membrane (PM) for biological activity. We show here that multiple acid sphingomyelinase (ASM) inhibitors, including tricyclic antidepressants, mislocalized phosphatidylserine (PtdSer) and K-RasG12V from PM, resulting in abrogation of signaling potent, selective growth inhibition mutant K-Ras-transformed cancer cells. Concordantly, nude mice, ASM inhibitor fendiline decreased rate oncogenic K-Ras-expressing MiaPaCa-2 tumors but had no effect on wild-type...
Net1A is a RhoA GEF that required for cell motility and invasion in multiple cancers. Nuclear localization of negatively regulates its activity, we have recently shown Rac1 stimulates relocalization to the plasma membrane promote activation cytoskeletal reorganization. However, mechanisms controlling subcellular are not well understood. Here, show contains two nuclear signal (NLS) sequences within amino-terminus residues surrounding second NLS sequence acetylated. Treatment cells with...
Stress urinary incontinence (SUI) is a common clinical postpartum complication. It necessary to explore the risk factors of SUI in primiparas provide evidence support for preventing and reducing occurrence SUI.Primiparas who were delivered our hospital from March 2019 October 2020 identified, personal information related treatment details no-SUI collected analyzed. Logistic regression analyses conducted identify primiparas.A total 612 included, incidence was 32.03%. There significant...
Krüppel-like factor 4 (KLF4) is an epithelial-specific transcription primarily expressed in the gastrointestinal tract that mediates growth arrest colonic epithelium. We tried to find whether KLF4 expression associated with progression and differentiation of colorectal cancer.We detected 109 specimens (40 normal appearing mucosa, 7 adenomas, 62 carcinomas) by immunohistochemistry using a tissue microarray. Western blot RT-PCR analyses were also performed.The upregulation carcinoma was...
The influencing factors of gestational diabetes mellitus (GDM) in the polycystic ovary syndrome (PCOS) patients remain unclear, we aimed to investigate risk GDM with PCOS, provide reliable evidence for prevention and treatment PCOS patients.PCOS treated our hospital from January 1, 2019 October 31, 2020 were included. personal clinical details no analyzed. Logistic regressions performed analyze occurrence GDM.A total 196 included, incidence was 23.98%. There significant differences age, body...
Abstract Co‐infection in patients with severe fever thrombocytopenia syndrome (SFTS) has been reported, posing a serious threat to survival and treatment. We aimed systematically investigate the SFTS associated pulmonary infection, particularly invasive fungal infection (IPFI). During April 2019 October 2021, we conducted multicentre observational study on adult hospitalized confirmed from three tertiary hospital central China. Demographic, clinical laboratory data of were collected...
This study was conducted to acknowledge microbiological and clinical characteristics of hospital-acquired pneumonia (HAP) caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). A retrospective, 1:1 matched (age, gender, specimen source, ward) case-control during 2015–2017 in a tertiary teaching hospital Anhui, China. Multivariate logistic regression analysis demonstrated that prior central venous catheter use, sputum suction, continuous renal replacement therapy, exposure...
Abstract Cancer-associated cachexia, characterized by muscle wasting, is a lethal metabolic syndrome without defined etiology or established treatment. We previously found that p300 mediates cancer-induced wasting activating C/EBPβ, which then upregulates key catabolic genes. However, the signaling mechanism activates in response to cancer unknown. Here, we show upon activation of Toll-like receptor 4 skeletal muscle, p38β MAPK phosphorylates Ser-12 on stimulate C/EBPβ acetylation, necessary...
The eradication of cancer stem cells (CSCs) with drug resistance confers the probability local tumor control after chemotherapy or targeted therapy. As main marker, ABCG2 is also critical for colorectal (CRC) evolution, in particular stem–like traits expansion. Hitherto, knowledge about expression regulation ABCG2, its upstream transcriptional regulatory mechanisms, remains limited cancer, including CRC. Here, was found to be markedly up–regulated CRC CSCs (cCSCs) expansion and...
Objectives To explore the postsurgery lived experiences of patients with colorectal cancer a permanent ostomy for informing initiatives to improve patient care and future quantitative research. Design A descriptive qualitative phenomenological study. Setting We conducted this study in Colorectal Cancer Division at Center West China Hospital, Sichuan University, premier institution renowned its comprehensive Participants 12 who had undergone surgeries ostomy. Results Our interviews revealed...
Spermatogenesis is regulated by a cascade of steroid genes in the testis. Recent studies suggested that acupuncture may improve fertility men with abnormal semen parameters. Yet, underlying mechanisms which enhances spermatogenesis remain largely unknown. Here we used scrotal heat-treated rat model to study effect electroacupuncture (EA) on recovery spermatogenesis. In this model, was disrupted 30 min heat treatment at 43°C. Ten sessions EA were given Baihui (GV20), Guanyuan (CV4), Zusanli...