A5070525281- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Advanced Breast Cancer Therapies
- Chemical Reactions and Isotopes
- Prostate Cancer Treatment and Research
- Biological Research and Disease Studies
- Enzyme function and inhibition
- Nanoparticle-Based Drug Delivery
- Cancer Cells and Metastasis
- Computational Drug Discovery Methods
- Radiopharmaceutical Chemistry and Applications
- Pancreatic and Hepatic Oncology Research
- Metal complexes synthesis and properties
- Heat shock proteins research
- NF-κB Signaling Pathways
- Peptidase Inhibition and Analysis
- Nanoplatforms for cancer theranostics
- Free Radicals and Antioxidants
- Cancer, Lipids, and Metabolism
- Mass Spectrometry Techniques and Applications
- Fatigue and fracture mechanics
- Caveolin-1 and cellular processes
- Metabolomics and Mass Spectrometry Studies
- Immune Cell Function and Interaction
- Advanced Proteomics Techniques and Applications
Klinikum rechts der Isar
2021-2023
The University of Texas Health Science Center at Houston
2016
University of Maryland, Baltimore
2016
University of Maryland Baltimore Washington Medical Center
2016
University of Bristol
2012-2015
Abstract Despite the high mortality from metastatic cancer, therapeutic targets to prevent metastasis are limited. Efforts identify genetic aberrations that predispose tumors have been mostly unsuccessful. To understand nature of candidate for disease, we performed an in silico screen drugs can inhibit a gene expression signature associated with epithelial–mesenchymal transition (EMT). Compounds discovered through this method, including those previously identified, appeared restrict capacity...
Colorectal cancer remains the fourth most common cause of cancer-related mortality worldwide. Here we investigate role nuclear factor-κB (NF-κB) co-factor B-cell CLL/lymphoma 3 (BCL-3) in promoting colorectal tumour cell survival.Immunohistochemistry was carried out on 47 samples and normal tissue from resection margins. The BCL-3/NF-κB complexes growth studied vivo vitro using an siRNA approach exogenous BCL-3 expression adenoma carcinoma cells. question whether activated AKT/protein kinase...
The mortality of patients with pancreatic ductal adenocarcinoma (PDAC) is strongly associated metastasis, a multistep process that incompletely understood in this disease. Although genetic drivers PDAC metastasis have not been defined, transcriptional and epigenetic rewiring can contribute to the metastatic process. eraser histone deacetylase 2 (HDAC2) has connected less differentiated PDAC, but function HDAC2 comprehensively evaluated. Using genetically defined models, we show cellular...
Although the retinoblastoma-susceptibility gene RB1 is inactivated in a wide range of human tumours, colorectal cancer, retinoblastoma protein (Rb) function often preserved and RB locus even amplified. Importantly, we have previously shown that Rb interacts with anti-apoptotic Bcl-2 associated athanogene 1 (BAG-1) protein, which highly expressed carcinogenesis. Here show for first time expression critical BAG-1 activity tumour cells. We demonstrate not only increases nuclear localisation but...
Abstract Background: Population based BC screening with XRAY mammography (MM) has been widely accepted as standard of care for women aged 40+ average risk developing BC. Sensitivity and specificity MM is dependent on breast tissue density up to ∼20% are undetected by MM. The development a dependable, low cost blood-based test increase the sensitivity currently existing methods needed. Rationale: GP88 expressed & secreted cells not normal mammary epithelial cells, 2 retrospective...
Abstract New therapeutic targets that can inhibit cancer metastasis are desperately needed. To address this issue, we have leveraged a computational approach and performed an unbiased screen for therapies epithelial-to-mesenchymal transition (EMT) gene expression profile, phenotype is believed to promote metastases. This yielded predictions of drugs both EMT transcriptional profile. Following up on these predictions, confirmed experimentally induce or repress in range breast cell lines....
<div>Abstract<p>Despite the high mortality from metastatic cancer, therapeutic targets to prevent metastasis are limited. Efforts identify genetic aberrations that predispose tumors have been mostly unsuccessful. To understand nature of candidate for disease, we performed an <i>in silico</i> screen drugs can inhibit a gene expression signature associated with epithelial–mesenchymal transition (EMT). Compounds discovered through this method, including those previously...
<div>Abstract<p>The mortality of patients with pancreatic ductal adenocarcinoma (PDAC) is strongly associated metastasis, a multistep process that incompletely understood in this disease. Although genetic drivers PDAC metastasis have not been defined, transcriptional and epigenetic rewiring can contribute to the metastatic process. The eraser histone deacetylase 2 (HDAC2) has connected less differentiated PDAC, but function HDAC2 comprehensively evaluated. Using genetically...
<div>Abstract<p>The mortality of patients with pancreatic ductal adenocarcinoma (PDAC) is strongly associated metastasis, a multistep process that incompletely understood in this disease. Although genetic drivers PDAC metastasis have not been defined, transcriptional and epigenetic rewiring can contribute to the metastatic process. The eraser histone deacetylase 2 (HDAC2) has connected less differentiated PDAC, but function HDAC2 comprehensively evaluated. Using genetically...
Supplementary Data from HDAC2 Facilitates Pancreatic Cancer Metastasis
Supplementary Figure from HDAC2 Facilitates Pancreatic Cancer Metastasis
Supplementary Figure from HDAC2 Facilitates Pancreatic Cancer Metastasis
Supplementary Data from HDAC2 Facilitates Pancreatic Cancer Metastasis
<p>ABCA1 drives metastasis in vivo.</p>