LncRNA in non-homologous end joining (NHEJ) pathway 1 (LINP1) is an lncRNA which promotes therapeutic resistance triple-negative breast cancer (TNBC). However, the expression and function of LINP1 cervical not yet well-understood. In this study, we evaluated levels tumor tissues cell lines cancer. We found that associates with NHEJ proteins (Ku80 DNA-PKcs). translocates from cytosol to nucleus response irradiation. addition, knockdown significantly increases cleaved caspase3 PARP, leading...

Abstract Bedaquiline is employed to treat multidrug‐resistant and extensive drug‐resistant tuberculosis by inhibiting the proton pump of adenosine triphosphate synthase in Mycobacterium . This study aims investigate effect high‐fat diets on pharmacokinetics bedaquiline through a single‐center, open‐label, randomized trial healthy Chinese participants. fumarate tablets were administered at dosage 100 mg under both fasted conditions diet conditions. The concentrations determined using liquid...

Background: C arbapenem-resistant Klebsiella pneumoniae (CRKP) infections may increase the potential for mortality in kidney transplant (KT) recipients. This study aimed to investigate clinical features, molecular epidemiology, virulence, and antimicrobial resistance of KP strains from KT patients. Methods: Strains isolated patients were collected, susceptibility analysis was verified via Vitek2 compact instrument disc diffusion method. In gene expression analysis, carbapenemase genes...

Radiotherapy stands as a cornerstone in the treatment of numerous malignant tumors, including non-small cell lung cancer. However, critical challenge amplifying tumoricidal effectiveness radiotherapy while minimizing collateral damage to healthy tissues remains an area significant research interest. Radiosensitizers, by methods such DNA and fostering creation free radicals, play pivotal role enhancing destructive impact on tumors. Over recent decades, nano-dimensional radiosensitizers have...

Natural long-chain alkanol and alkyl carboxylic acid were used to prepare novel hydrophobic deep eutectic solvents (HDESs). These HDESs are liquid at room temperature have low viscosity (<12.26 mPa‧s), polarity (lower than that of methanol, ChCl-based other reported HDESs), density (<0.928 g/mL). A simple one-pot method based on a HDES-water two-phase extraction system was constructed for the weak-polarity bioactive components, anthraquinones, from Rhei Radix et Rhizoma. This HDES-based new...

We aim to investigate the prognostic factors and evaluate role of carcinoembryonic antigen (CEA) carbohydrate 19-9 (CA19-9) in local advanced rectal cancer (LARC) patients who received neoadjuvant chemoradiotherapy (neo-CRT), radical surgery postoperative chemotherapy.In total, 197 cases LARC underwent neo-CRT, total mesorectal excision (TME), adjuvant chemotherapy were recruited. Serum levels CEA CA19-9 detected both at baseline after neo-chemoradiotherapy. Multivariate analysis was used...

Dacomitinib, the second-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has been used as a first-line treatment in non-small cell lung cancer (NSCLC) patients harboring EGFR mutation. In this case, we report patient with drug-induced liver injury (DILI) associated use of dacomitinib. A 59-year-old man stage IV NSCLC was prescribed dacomitinib; 37 days after dacomitinib administration, he admitted to our hospital because jaundice. Laboratory examinations...

Radiotherapy and cisplatin-based chemotherapy are currently considered as standard treatments employed for advanced cervical cancer (CC). However, patients with local recurrence or distant metastasis continue to have poor outcomes. EGFR overexpression correlated chemo/radioresistance, disease failure has been well proved in the previous studies. Hence, aim of this study was explore therapeutic efficacy underlying mechanism sensitization radiation cisplatin icotinib hydrochloride (IH), a...

Artemis is a key protein of NHEJ (nonhomologous end joining), which the major pathway for repair IR-induced DSBs in mammalian cells. However, expression tumors and influence silencing on tumor sensitivity to radiation have not been investigated fully. In this study, we how levels may affect treatment outcome radiotherapy chemotherapy colorectal cancer First, found that strong some human rectal samples, being higher than adjacent normal tissues using immunohistochemical staining. We then...

Radiotherapy and chemotherapy are the main clinical treatments for biliary tract cancers (BTCs). Patients with advanced disease have a very poor prognosis, yet no molecular targets been proven effective adjuvant therapy of BTCs. In this study, we aimed to explore effect combination treatment icotinib hydrochloride (IH) fluzoparib (FZ) on radiosensitivity clarify its underlying mechanism in HCCC-9810 GBC-SD human BTC cell lines.Cell proliferation was measured by Cell Counting Kit-8 (CCK-8)...

There are clinics around nursing homes in foreign countries or family doctors for every elderly. When a disease occurs, can provide door to service help patients. Since the epidemic of coronavirus 2019, elderly have been high risk group people infected with 2019. In both United States and Canada, first recorded 2019 deaths outbreaks occurred case fatality rates these settings reported be as 33.7 %. Due lack adequate medical facilities staff services, more likely virus result social...

A novel hexafluoroisopropanol (HFIP)-octanol supramolecular solvent (SUPRAS) based dispersive liquid-liquid microextraction (DLLME) method was developed for the determination of 2,6-dimethylaniline (2,6-DMA) in lidocaine hydrochloride injection coupled with high performance liquid chromatography-ultraviolet detection (HPLC-UV). n-Octanol selected as extraction while HFIP served dispersing agent, self-assembly inducer n-octanol well density-regulating agent n-octanol. The HFIP-octanol SUPRAS...

The comprehensive effects of nanoparticles and coexisting heavy metals on plant growth are still unclear, especially in soil medium. single combined multiwall carbon nanotubes (MWCNTs) cadmium (Cd) rice ( Oryza sativa L.) were examined this study through a 4 months pot experiment 2022. Rice plants exposed to different concentrations MWCNTs (100 500 mg kg −1 ) the presence 5.0 Cd stress. At tillering stage, addition reduced height by 8.0% increased soluble protein content leaves 13.7%,...