A5100385206- Sperm and Testicular Function
- Microbial Natural Products and Biosynthesis
- Reproductive Biology and Fertility
- Cardiac Arrhythmias and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Synthetic Organic Chemistry Methods
- Atrial Fibrillation Management and Outcomes
- Respiratory viral infections research
- Influenza Virus Research Studies
- Diabetes Treatment and Management
- HIV/AIDS drug development and treatment
- COVID-19 diagnosis using AI
- Metabolism, Diabetes, and Cancer
- Lung Cancer Research Studies
- Bee Products Chemical Analysis
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- RNA and protein synthesis mechanisms
- Reproductive biology and impacts on aquatic species
- Inflammatory Biomarkers in Disease Prognosis
- Immune Response and Inflammation
- Pelvic floor disorders treatments
- AI in cancer detection
- Anorectal Disease Treatments and Outcomes
- Cancer-related Molecular Pathways
Jinan Central Hospital
2021-2025
Shandong First Medical University
2023-2025
Sun Yat-sen University
2021-2025
Shandong Tumor Hospital
2025
Shanghai Institute of Organic Chemistry
2024
China National Institute of Standardization
2024
First Hospital of Jilin University
2022-2024
Jilin University
2010-2024
Shandong Provincial Hospital
2024
Hebei Medical University
2023-2024
Background The Global School Student Health Survey (GSHS) is being carried out by students in various countries across the globe to advance improved health programs for youth. However, comparison high-income countries, adolescents low- and middle-income (LMICs) are generally at an early stage of understanding regarding physical activity (PA) sedentary behavior (SB), often exhibiting low levels PA high SB. Furthermore, there limited evidence connecting SB school-going from LMICs. Purpose...
Abstract Bedaquiline is employed to treat multidrug‐resistant and extensive drug‐resistant tuberculosis by inhibiting the proton pump of adenosine triphosphate synthase in Mycobacterium . This study aims investigate effect high‐fat diets on pharmacokinetics bedaquiline through a single‐center, open‐label, randomized trial healthy Chinese participants. fumarate tablets were administered at dosage 100 mg under both fasted conditions diet conditions. The concentrations determined using liquid...
This study proposes a multi-target strategy to combat sepsis by eliminating ROS and suppressing cGAS-STING pathway activation, the approach mitigates cytokine storms sepsis-induced organ failure.
Objective Although preoperative prediction of axillary lymph nodes status has been achieved using radiomics and combined models, there is a dearth research on internal mammary node (IMN) metastasis prediction. We developed predictive model by combining clinicopathological factors with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to accurately predict IMN in breast cancer. Methods Patients who had no evidence images but underwent sentinel biopsy (IM-SLNB) were included this...
Methoxetamine hydrochloride (ET-26-HCl) is a novel short-acting intravenous general anesthetic that retains the advantages of etomidate while minimizing its impact on adrenal cortical function. A single-center, randomized, open-label, placebo-controlled clinical trial was conducted using concentration-QTc (C-QTc) model analysis to evaluate pharmacokinetics, sedative effect, safety, and potential risk QT interval prolongation ET-26-HCl at doses 0.8 mg/kg (the dosage) 2.8 mg/kg. In group, mean...
ABSTRACT Boosting apoptotic cell clearance by phagocytes including colonic epithelial cells (CECs), a process named efferocytosis, inhibits colitis development. Lactucopicrin (LCP), one common bitter sesquiterpene lactone affluent in leafy vegetables possesses significant antiinflammatory property. However, it remains unknown whether LCP could regulate CECs efferocytosis and development vivo. Methods Results: (0.25‐1 µmol/L) does not appreciably change the efferocytic capacity of murine...
The objective of the study was to develop and validate a radiomics-based formula for preoperative prediction postoperative pancreatic fistula (POPF) in patients undergoing pancreaticoduodenectomy (PD).A total 117 consecutive who underwent PD were enrolled this retrospective study. Radiomics features extracted from portal venous phase computed tomography above patients. least absolute shrinkage selection operator logistic regression used construct Rad-score calculation. Then performance...
Insulin-like growth factor-1 (IGF-1) is a potent mitogen for osteoblasts. The primary signaling mechanism involved in mediating this proliferative effect of IGF-1 not well defined. roles extracellular signal-regulated kinase 1 (ERK1) and cyclin-dependent 2 (Cdk2) kinases the IGF-1-induced pathway human osteosarcoma MG63 cells were investigated using selective inhibitor MEK, PD98059, Cdk inhibitor, olomoucine. Treatment with PD98059 olomoucine inhibited IGF-1-stimulated proliferation these...
Abstract Injections of parathyroid hormone (PTH) have been reported to stimulate skeletal accretion through increased bone formation in several species, and osteoblast proliferation is a critical component formation. However, the biological mechanisms PTH-stimulated cell are largely unknown. In this study, we demonstrated that PTH stimulates precursor line, TE-85, association with increasing cdc2 protein levels its kinase activity. antisense oligonucleotides blocked PTH-induced DNA synthesis...
Sophora Tonkinensis Gagnep. (STG) has been used as a folk medicine for the treatment of different cancers, especially nasopharyngeal carcinoma, cervical cancer, liver stomach lung cancer and leukemia in China. However, main chemical composition anticancer mechanism chloroform extract STG (CESTG) were still not very clear.
Abstract The purpose of this test was to investigate the effect salvianic acid A (SAA, CAS No. 76822‐21‐4) on quality boar semen during liquid storage at 17°C. effects different concentrations SAA and antioxidant capacity were analyzed. Boar diluted with Beltsville Thawing Solution (BTS) containing (0, 15, 30, 45, 60, 75 μM SAA). During period, sperm activity measured every 24 hr, plasma membrane integrity, acrosome total (T‐AOC), malondialdehyde (MDA) content, catalase (CAT) 0, 1, 3, 5...
Alternation in culture environment due to cell-cell communications can rejuvenate the biological activity of aged/differentiated cells and stimulate expression pluripotency markers. Dental pulp (DPCs) periodontal ligament (PDLCs) are promising candidates dental tissue regeneration. However, molecular network that underlies between dental-derived microenvironment remains be identified. To elucidate signaling regulates DPCs PDLCs, proliferation, apoptosis, cell cycle, Oct-4/Sox2/c-Myc PDLCs...
Abstract Background Rosai-Dorfman Disease (RDD) is a rare self-limiting histiocytosis, more prevalent in children and young adults. It typically manifests as painless bilateral massive cervical lymphadenopathy but may also extend to extra-nodal sites, with intrathoracic RDD noted 2% of cases. Distinguishing mediastinal from thymoma on imaging poses challenges, underscoring the reliance pathological features immunohistochemical staining for diagnosis. Case presentation Patient, male, 33 years...
Introduction: Immunotherapy has led to a paradigm shift in reinvigorating treatment of cancer.Nevertheless, tumor associated macrophages (TAMs) experience functional polarization on account the generation suppressive metabolites, contributing impaired antitumor immune responses.Methods: Hence, metabolic reprogramming microenvironment (TME) can synergistically improve efficacy anti-tumor immunotherapy.Herein, we engineered an iron-based nanoplatform termed ER Fe 3 O 4 NPs.This platform...