A5003933646- Knee injuries and reconstruction techniques
- Hip and Femur Fractures
- Extracellular vesicles in disease
- Sports injuries and prevention
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Pelvic and Acetabular Injuries
- Bone fractures and treatments
- Hip disorders and treatments
- Orthopedic Surgery and Rehabilitation
- MicroRNA in disease regulation
- Elbow and Forearm Trauma Treatment
- Shoulder and Clavicle Injuries
- Shoulder Injury and Treatment
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury Research
- Musculoskeletal Disorders and Rehabilitation
- Innovations in Medical Education
- Winter Sports Injuries and Performance
- Heat shock proteins research
- Lower Extremity Biomechanics and Pathologies
- Endoplasmic Reticulum Stress and Disease
- Diversity and Career in Medicine
- Foot and Ankle Surgery
- Immune cells in cancer
Columbia University Irving Medical Center
2020-2024
Columbia University
2020-2024
Texas Health Dallas
2020-2023
NewYork–Presbyterian Hospital
2020-2023
New York Hospital Queens
2020-2023
Steadman Philippon Research Institute
2020
Steadman Clinic
2020
University of Colorado Denver
2014-2019
University of Colorado Hospital
2019
University of Colorado Anschutz Medical Campus
2015-2017
Glioma-related immunosuppression is well documented; however, the mechanisms of suppression are not fully understood. Here we explore a role for glioma extracellular vesicles (EVs) as means immune modulation. Healthy donor peripheral blood mononuclear cells (PBMCs) were incubated with mitogenic stimuli and various concentrations glioma-derived EVs. Intracellular signaling cytokine output determined by protein microarrays, phenotypic changes assessed flow cytometry. Recall antigen testing,...
Glioblastoma multiforme (GBM) is a devastating tumour with abysmal prognoses. We desperately need novel approaches to understand GBM biology and therapeutic vulnerabilities. Extracellular vesicles (EVs) are membrane-enclosed nanospheres released locally systemically by all cells, including tumours, tremendous potential for intercellular communication. Tumour EVs manipulate their local environments as well distal targets; may be mechanism tumourigenesis in the recurrent setting. hypothesized...
Aging leads to several geriatric conditions including osteoporosis (OP) and associated frailty syndrome. Treatments for these are limited none target fundamental drivers of pathology, thus identifying strategies delay progressive loss tissue homeostasis functional reserve will significantly improve quality life in elderly individuals. A property aging is the accumulation senescent cells. Senescence a cell state defined by proliferative capacity, resistance apoptosis, release proinflammatory...
Physical activity reduces the incidence and severity of psychiatric disorders such as anxiety depression. Similarly, voluntary wheel running produces anxiolytic- antidepressant-like effects in rodent models. The specific neurobiological mechanisms underlying beneficial properties exercise, however, remain unclear. One relevant pharmacological target treatment is 5-HT2C receptor (5-HT2CR). Consistent with data demonstrating anxiogenic consequences 5-HT2CR activation humans rodents, we have...
Background: Meniscal vascular supply is an important determinant of its healing potential. It has been reported that only the peripheral 30% meniscus vascularized in cadavers aged 53 to 94 years; however, vascularity young patients, whom meniscal repair more often performed, unknown. Purpose: The primary objective was analyze and measure microvascular anatomy adult cadaveric specimens <35 years old. secondary assess angiogenic potential by quantifying regional gene expression a allograft...
Abstract Skiing and snowboarding are popular competitive recreational sports that can be associated with significant injury. Previous studies of skiing injuries have been conducted, but evaluating injury types patterns over long periods time needed to drive effective prevention efforts. We hypothesized would differ among snowboarders skiers the number remained constant time. This is a retrospective study patients presenting or United States emergency departments from 2000 2019. A total...
Agents targeting HSP90 and GRP94 are seldom tested in stressed contexts such as heat shock (HS) or the unfolded protein response (UPR). Tumor stress often activates HSPs UPR pro-survival mechanisms. This begs question of effects on chemotherapeutic efficacy, particularly with drugs chaperones GRP94. We utility several inhibitors, including PU-H71 (targeting GRP94), a primary canine lung cancer line under HS/UPR compared to control conditions.We cultured bronchoalveolar adenocarcinoma cells...
Brain tumors such as high grade gliomas are among the deadliest forms of human cancers. The tumor environment is subject to a number cellular stressors hypoxia and glucose deprivation. persistence activates unfolded proteins response (UPR) results in global alterations transcriptional translational activity cell. Although UPR known effect tumorigenesis some epithelial cancers, relatively little about role brain tumors. Here, we evaluated changes at molecular level under homeostatic stress...
Athletes are known to under-report concussion symptoms due competitive disincentives report and conflation of with other conditions associated rigorous participation ...
Musculoskeletal (MSK) disease comprises over 20% of all visits to healthcare providers each year, yet a disproportionately small percentage medical school education focuses on MSK disease. Even among students applying into orthopaedic surgery, less than 50% demonstrate prerequisite anatomic knowledge before beginning their residency. Medical curriculum reform is needed, given that only 15% have required curriculum. Inadequate ultimately leads poor patient care and forces clinicians learn...
Abstract Background Subdermal etonogestrel implants are highly effective contraceptive methods. Despite standardization of insertion technique by the manufacturer, some inadvertently placed too deeply within or below plane biceps brachii fascia. Placement these in a deep tissue results more difficult removal, which is not always possible office setting. In rare cases, surgical removal an upper extremity surgeon warranted. Case presentation Here we present 6 cases located subfascial requiring...
Congenital hypertrophy of the intrinsic muscles foot is a rare disorder unknown incidence characterized by unilateral muscular one or more muscles. Few cases have been reported in literature, many presenting with single muscle.A 12-year-oldCaucasian female all right present since birth presented muscle imbalance resulting hammer toe deformities second and third toes crossing over hallux. Our treatment consisted correction without debulking excision.Isolated congenital poses unique challenge,...