A5044221179- Gut microbiota and health
- Diet and metabolism studies
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Infant Nutrition and Health
- Infant Health and Development
- Language and Culture
- Dietary Effects on Health
- Anesthesia and Neurotoxicity Research
- Transcranial Magnetic Stimulation Studies
- Reproductive System and Pregnancy
- Linguistics, Language Diversity, and Identity
- Hormonal Regulation and Hypertension
- Probiotics and Fermented Foods
- Renin-Angiotensin System Studies
- Education and Cultural Studies
- Neurological disorders and treatments
- Neural dynamics and brain function
- Polish Historical and Cultural Studies
- Birth, Development, and Health
- Receptor Mechanisms and Signaling
University of Colorado Boulder
2012-2019
Arizona State University
2011-2012
Charité - Universitätsmedizin Berlin
2010
The mammalian intestine harbors a complex microbial ecosystem that influences many aspects of host physiology. Exposure to specific microbes early in development affects metabolism, immune function, and behavior across the lifespan. Just as physiology developing organism undergoes period plasticity, is characterized by instability may also be more sensitive change. Early life thus presents window opportunity for manipulations produce adaptive changes composition. Recent insights have...
Severe, repeated or chronic stress produces negative health outcomes including disruptions of the sleep/wake cycle and gut microbial dysbiosis. Diets rich in prebiotics glycoproteins impact microbiota may increase species that reduce stress. This experiment tested hypothesis consumption dietary prebiotics, lactoferrin (Lf) milk fat globule membrane (MFGM) will physiological impacts Male F344 rats, postnatal day (PND) 24, received a diet with Lf MFGM (test) calorically matched control diet....
Chronic stress leads to neurochemical and structural alterations in the prefrontal cortex (PFC) that correspond deficits PFC-mediated behaviors. The present study examined effects of chronic restraint on response inhibition (using a response-withholding task, fixed-minimum interval schedule reinforcement, or FMI), working memory radial arm water maze, RAWM). Adult male Sprague-Dawley rats were first trained RAWM subsequently FMI. After acquisition FMI, assigned (6h/d/28d wire mesh...
Abstract Manipulating gut microbes may improve mental health. Prebiotics are indigestible compounds that increase the growth and activity of health‐promoting microorganisms, yet few studies have examined how prebiotics affect CNS function. Using an acute inescapable stressor known to produce learned helplessness behaviours such as failure escape exaggerated fear, we tested whether early life supplementation a blend two prebiotics, galactooligosaccharide ( GOS ) polydextrose PDX ),...
Physical activity reduces the incidence and severity of psychiatric disorders such as anxiety depression. Similarly, voluntary wheel running produces anxiolytic- antidepressant-like effects in rodent models. The specific neurobiological mechanisms underlying beneficial properties exercise, however, remain unclear. One relevant pharmacological target treatment is 5-HT2C receptor (5-HT2CR). Consistent with data demonstrating anxiogenic consequences 5-HT2CR activation humans rodents, we have...
Abstract Chronic stress results in reversible spatial learning impairments the Morris water maze that correspond with hippocampal CA3 dendritic retraction male rats. Whether chronic impacts different types of memory domains, and whether these can similarly recover, is unknown. This study assessed effects without a post‐stress delay to evaluate deficits within two reference working memory, radial arm (RAWM). Three groups 5‐month‐old Sprague–Dawley rats were either not stressed [control...
Early life nutrition impacts many aspects of physiology and behavior. In our previous studies, rats fed prebiotic diets exhibited reduced anxiety depressive‐like behavior produced by uncontrollable stress. The current study tested if 4 weeks early that vary in prebiotics (galactooligosaccharide, GOS + polydextrose, PDX) globular glycoprotein (lactoferrin, LAC) would change the activation ( cfos mRNA expression) brain regions associated with central stress response. examined were dorsal raphe...
During recent years the so-called “kidney-heart-connection” has been increasingly recognised meaning that chronic kidney disease (CKD) is not only consequence but also cause of cardiac disease. The AT2R described to act anti-inflammatory and anti-fibrotic. However, up now a therapeutic use these features could be considered due lack suitable, orally active AT2R-agonist. Such an selective, non-peptide AT2R-agonist termed Compound 21 (C21) was recently synthesised tested in this study as...