A5100434908- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Epigenetics and DNA Methylation
- Phytochemistry and Biological Activities
- Cancer-related gene regulation
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Air Quality and Health Impacts
- Bioactive natural compounds
- Microbial Metabolic Engineering and Bioproduction
- GDF15 and Related Biomarkers
- Circular RNAs in diseases
- Liver physiology and pathology
- Plant Reproductive Biology
- Trypanosoma species research and implications
- Molecular Sensors and Ion Detection
- Microbial bioremediation and biosurfactants
- Plant Gene Expression Analysis
- Pharmacological Effects of Natural Compounds
- ATP Synthase and ATPases Research
- Galectins and Cancer Biology
- Cancer Mechanisms and Therapy
- Renal and related cancers
- Vitamin C and Antioxidants Research
- Light effects on plants
VIB-UGent Center for Plant Systems Biology
2023-2024
Ghent University
2023-2024
Jiangjin Central Hospital
2022-2024
Chongqing University
2022-2024
Sun Yat-sen University
2017-2024
Xuzhou Medical College
2006-2023
Wuhan University
2023
Jiangnan University
2021-2023
Tianjin University of Science and Technology
2022
Guangxi University
2020
Regulating inflammation could be an important measure for the effective treatment of cancer. Here we examine mechanisms by which oroxylin A inhibits in RAW264.7 cells. The results demonstrate that pretreatment with (50, 100, and 150 μmol/L) inhibited lipopolysaccharide (LPS)-induced mRNA protein expression COX-2 iNOS. In addition, significantly increased nuclear factor erythroid 2-related 2 (Nrf2), heme oxygenase 1 (HO-1), NADP(H):quinone oxidoreductase (NQO1), induced Nrf2 translocation to...
Colorectal cancer is a malignancy with high incidence and mortality worldwide, ulcerative colitis (UC) strongly associated colorectal cancer. Purple yam, also known as Dioscorea alata, has been reported to be rich in plant polyphenols that have possessed anti-inflammatory, antioxidant, antitumor properties. However, it not clear whether purple yam polyphenol extracts (PYPE) can improve inhibit colitis-related tumorigenesis. Therefore, we used dextran sulfate sodium (DSS)-induced azoxymethane...
Nonsmall cell lung cancer (NSCLC) is highly malignant with limited treatment options, platinum-based chemotherapy a standard for NSCLC resistance commonly seen. cells exploit enhanced antioxidant defense system to counteract excessive reactive oxygen species (ROS), which contributes largely tumor progression and chemotherapy, yet the mechanisms are not fully understood. Recent studies have suggested involvement of histones in cellular response; however, whether major histone variant H1.2...
Numerous polysaccharides isolated from plants have been used to augment traditional drugs in the treatment of cancer. In order explore influence hepatocellular carcinoma, a novel cold water-soluble polysaccharide was separated Rhodiola rosea L. root (RLP) and then its structure anti-cancer activities were tested. The chemical compositions high performance gel permeation chromatography (HPGPC) results indicated that RLP an acid heteropolysaccharide with molecular weight about 1.15×106 Da....
Excessive exposure to N,N-dimethylformamide (DMF) can lead occupational liver poisoning in workers; however, the underlying mechanism is not fully clarified. The importance of microRNAs (miRNAs) chemical-induced hepatotoxicity has been demonstrated. To determine whether miRNAs are also involved DMF-induced hepatotoxicity, we systematically analyzed miRNA expression profiles DMF-treated (75 and 150 mm) HL-7702 cells controls by high-throughput sequencing. Among altered miRNAs, miR-192-5p was...
Benzene, toluene, and xylene (BTX) co-exist in human environments, yet their individual combined effects on genetic damage at low exposure levels are not fully understood. Additionally, single nucleotide polymorphisms microRNAs (mirSNPs) might be involved cancer etiology by affecting the related early health damage. To investigate influence of BTX exposure, mirSNPs, interactions damage, we conducted a cross-sectional study 1083 Chinese petrochemical workers, quantifying cumulative multiple...
Abstract N , ‐dimethylformamide (DMF) is a colorless industrial solvent that frequently used for chemical reactions. Epidemiologic studies and clinical case reports have consistently indicated the main toxic effect after exposure to DMF hepatotoxicity. Previous suggested oxidative stress pivotal molecular event of DMF‐mediated hepatotoxicity; however, its underlying mechanism remains unclear. In this study, we found (0–150 mM) induced an increase in reactive oxygen species (ROS) levels...